EGFR (Epidermal Growth Factor Receptor)

Hatil, Ayca Circir
Çiçek, Esra
Öyken, Merve
Erson Bensan, Ayşe Elif
© 2020 Atlas of Genetics and Cytogenetics in Oncology and Haematology.ERBB family member epidermal receptor tyrosine kinase (EGFR) is composed of 28 exons and 27 introns. EGFR codes for 11 transcripts and 8 of them are protein coding. EGFR is a transmembrane glycoprotein that can be activated by several different ligands such as epidermal growth factor (EGF), transforming growth factor-alpha (TGFA), heparin-binding EGF-like growth factor (HBEGF), betacellulin (BTC), amphiregulin (AREG), epiregulin (EREG), and epigen (EPGN) (Singh, 2016). Ligand binding induces the dimerization of EGFR and autophosphorylation followed by a cascade of downstream phosphorylation events (Capuani et al., 2015). EGFR activation plays a key role in cell survival, proliferation, migration and differentiation (Purba, 2017).
Atlas of Genetics and Cytogenetics in Oncology and Haematology


EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers.
Cicek, Esra; Circir, Ayca; Oyken, Merve; Akbulut Caliskan, Ozge; Dioken, Didem Naz; Guntekin Ergun, Sezen; Cetin-Atalay, Rengul; Sapmaz, Aysegul; Ovaa, Huib; Sahin, Ozgur; Erson Bensan, Ayşe Elif (2021-10-30)
Epidermal growth factor receptor (EGFR) has critical roles in epithelial cell physiology. Over-expression and over-activation of EGFR have been implicated in diverse cancers, including triple-negative breast cancers (TNBCs), prompting anti‐EGFR therapies. Therefore, developing potent therapies and addressing the inevitable drug resistance mechanisms necessitates deciphering of EGFR related networks. Here, we describe Sorting Nexin 3 (SNX3), a member of the recycling retromer complex, as a critical player in...
Evaluation of neointimal hyperplasia on tranilast-coated synthetic vascular grafts: An experimental study
Karakayali, Feza; Haberal, Nihan; Tufan, Hale; Hasırcı, Nesrin; BaSaran, Ozgur; Sevmis, Sinasi; Akdur, Aydin; Kızıltay, Aysel; Haberal, Mehmet (2007-01-01)
Tranilast is an antiallergic drug that interferes with proliferation and migration of vascular smooth muscle cell induced by platelet-derived growth factor (PDGF) and transforming growth factor-beta 1 (TGF-beta 1). We investigated the local effect of tranilast on neointimal hyperplasia using tranilastcoated prosthetic grafts. The inner sides of the thin-walled polytetrafluoroethylene (PTFE) grafts were coated with chitosan and tranilast containing chitosan solution. Wistar albino rats (32) were used in the ...
ALCAM (Activated Leukocyte Cell Adhesion Molecule)
Yavuz, Esra; ÖYKEN, MERVE; Erson Bensan, Ayşe Elif (2018-01-01)
ALCAM (Activated Leukocyte Cell Adhesion Molecule), also known as CD166 (cluster of differentiation 166), is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain.
SNX3 (Sorting Nexin 3)
Çiçek, Esra; Öyken, Merve; Cingoz, Harun; Erson Bensan, Ayşe Elif (2020-01-01)
© 2020 Atlas of Genetics and Cytogenetics in Oncology and Haematology.Sorting Nexin 3 (SNX3) gene maps to chromosome 6, minus strand and has 4 exons and 3 introns. There are 3 alternatively spliced isoforms (transcripts). SNX3 is a member of the sorting nexin family. Members of this family generally have BAR domains and phosphoinositide binding regions called the phox (PX) domain, and are involved in intracellular trafficking. Unlike other sorting nexins, SNX3 does not contain a BAR domain. SNX3 protein int...
Metabolic network analysis for human therapeutic protein productions: Effects of the P/O ratio
Çalık, Pınar (2000-10-08)
The metabolic fluxes through the central carbon pathways in the bioprocesses for human leukocyte interferon (IFN-alpha(1)) and erythropoietin (EPO) overproductions by recombinant Bacillus sp, carrying the related human genes were determined separately, on two alternative carbon sources, i.e. glucose and citrate, which have different reduction degrees. In addition, the influence of the P/O ratio on the cell growth, IFN-alpha(1) and EPO productions were investigated. Thus, the potential influence of increased...
Citation Formats
A. C. Hatil, E. Çiçek, M. Öyken, and A. E. Erson Bensan, “EGFR (Epidermal Growth Factor Receptor),” Atlas of Genetics and Cytogenetics in Oncology and Haematology, pp. 325–332, 2020, Accessed: 00, 2020. [Online]. Available: