EGFR (Epidermal Growth Factor Receptor)

Date

2020-01-01

Author

Hatil, Ayca Circir
Çiçek, Esra
Öyken, Merve
Erson Bensan, Ayşe Elif

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© 2020 Atlas of Genetics and Cytogenetics in Oncology and Haematology.ERBB family member epidermal receptor tyrosine kinase (EGFR) is composed of 28 exons and 27 introns. EGFR codes for 11 transcripts and 8 of them are protein coding. EGFR is a transmembrane glycoprotein that can be activated by several different ligands such as epidermal growth factor (EGF), transforming growth factor-alpha (TGFA), heparin-binding EGF-like growth factor (HBEGF), betacellulin (BTC), amphiregulin (AREG), epiregulin (EREG), and epigen (EPGN) (Singh, 2016). Ligand binding induces the dimerization of EGFR and autophosphorylation followed by a cascade of downstream phosphorylation events (Capuani et al., 2015). EGFR activation plays a key role in cell survival, proliferation, migration and differentiation (Purba, 2017).

Subject Keywords

Colorectal cancer, Childhood, Panitumumab, Anti-EGFR

URI

https://hdl.handle.net/11511/57208

Journal

Atlas of Genetics and Cytogenetics in Oncology and Haematology

DOI

https://doi.org/10.4267/2042/70782

Collections

Department of Biology, Article

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Citation Formats

A. C. Hatil, E. Çiçek, M. Öyken, and A. E. Erson Bensan, “EGFR (Epidermal Growth Factor Receptor),” Atlas of Genetics and Cytogenetics in Oncology and Haematology, pp. 325–332, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/57208.