Is global BCG vaccination-induced trained immunity relevant to the progression of SARS-CoV-2 pandemic?



Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation.
Ishii, KJ; Takeshita, F; Gursel, I; Gürsel, Mayda; Conover, J; Nussenzweig, A; Klinman, DM (Rockefeller University Press, 2002-07-15)
Unmethylated CpG motifs present in bacterial DNA stimulate a strong innate immune response. There is evidence that DNA-dependent protein kinase (DNA-PK) mediates CpG signaling. Specifically, wortmannin (an inhibitor of phosphatidylinositol 3 kinase [PI3]-kinases including DNA-PK) interferes with CpG-dependent cell activation, and DNA-PK knockout (KO) mice fail to respond to CpG stimulation. Current studies establish that wortmannin actually inhibits the uptake and colocalization of CpG DNA with toll-like re...
Effect of suppressive DNA on CpG-induced immune activation.
Yamada, H; Gursel, I; Takeshita, F; Conover, J; Ishii, KJ; Gürsel, Mayda; Takeshita, S; Klinman, DM (The American Association of Immunologists, 2002-11-15)
Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs stimulate a strong innate immune response. This stimulation can be abrogated by either removing the CpG DNA or adding inhibitory/suppressive motifs. Suppression is dominant over stimulation and is specific for CpG-induced immune responses (having no effect on LPS- or Con A-induced activation). Individual cells noncompetitively internalize both stimulatory and suppressive ODN. Studies using ODN composed of both stimula...
Genetic variants within the endotoxin signaling pathway and asthma: an association study
ŞAHİNER, ÜMİT MURAT; YAVUZ, SİNAN; Buyuktiryaki, B.; BİRBEN, ESRA; Topaloglu, E.; TUNCER, ALAETTİN; Yaman, A.; Atalay, Rengül; Atalay, Mehmet Volkan; Sackesen, C.; Kalayci, O. (2011-06-01)
Interleukin-15 acts as an immunological co-adjuvant for liposomal antigen in vivo
Gürsel, Mayda (Elsevier BV, 1997-03-01)
The recently discovered interleukin-15 (IL-15) is known to bind to the receptor of interleukin-2 (IL-2) and to share several of the latter's immunological properties. In the present study, the first to our knowledge on IL-15 behaviour in vivo, we examined the possibility that IL-15 also shares the ability of IL-2 to enhance the immunological adjuvant property of liposomes by acting as a co-adjuvant. The cytokine and a model antigen (tetanus toroid) were either co-entrapped by the dehydration rehydration met...
Inhibition of the TIRAP-c-Jun interaction as a therapeutic strategy for AP1-mediated inflammatory responses
Srivastava, Mansi; Saqib, Uzma; Banerjee, Sreeparna; Wary, Kishore; Kizil, Burak; Muthu, Kannan; Baig, Mirza S. (Elsevier BV, 2019-06-01)
Bacterial endotoxin-induced sepsis causes 30-40% of the deaths in the intensive care unit (ICU) globally, for which there is no pharmacotherapy. Lipopolysaccharide (LPS), a bacterial endotoxin, stimulates the Toll-like receptor (TLR)-4 signalling pathways to upregulate the expression of various inflammatory mediators. Here, we show that the TIRAP and c-Jun protein signalling complex forms in macrophages in response to LPS stimulation, which increases the AP1 transcriptional activity, thereby amplifying the ...
Citation Formats
M. Gürsel, “Is global BCG vaccination-induced trained immunity relevant to the progression of SARS-CoV-2 pandemic?,” ALLERGY, pp. 1815–1819, 2020, Accessed: 00, 2020. [Online]. Available: