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ARID3B expression in primary breast cancers and breast cancer-derived cell lines

2014-08-01
ERDOGAN, Ayse Selcen Oguz
OZDEMIRLER, Nihan
ÖYKEN, MERVE
ALPER, Murat
Erson Bensan, Ayşe Elif
ARID3B (AT-rich interaction domain 3) is a member of the family of ARID proteins, which constitutes evolutionarily conserved transcription factors implicated in normal development, differentiation, cell cycle regulation and chromatin remodeling. In addition, ARID3B has been linked to cellular immortalization, epithelial-mesenchymal transition (EMT) and tumorigenesis. Given the emerging role of ARID3B in tumor development, we examined its expression in primary patient-derived breast cancer samples and breast cancer-derived cell lines.