A new synthon for the synthesis of aminoinositol derivatives

Cokol, Nalan Korkmaz
Kaya, Serap
The regio- and stereoselective synthesis of a new synthon, trans-3,8-dioxatricyclo[,4)]octane-6,7-diamine, from 7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate is reported. Transformation of the acid functionalities to acyl azides followed by Curtius rearrangement gave the corresponding trans-diisocyanate, which was reacted with HCl to produce a trans-diamino compound that is a potentially important synthon for the versatile synthesis of aminocyclitols.

Citation Formats
N. K. Cokol, S. Kaya, and M. BALCI, “A new synthon for the synthesis of aminoinositol derivatives,” TETRAHEDRON LETTERS, vol. 58, no. 28, pp. 2732–2735, 2017, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/40847.