A new synthon for the synthesis of aminoinositol derivatives

Date

2017-07-12

Author

Cokol, Nalan Korkmaz
Kaya, Serap
BALCI, METİN

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The regio- and stereoselective synthesis of a new synthon, trans-3,8-dioxatricyclo[3.2.1.0(2,4)]octane-6,7-diamine, from 7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate is reported. Transformation of the acid functionalities to acyl azides followed by Curtius rearrangement gave the corresponding trans-diisocyanate, which was reacted with HCl to produce a trans-diamino compound that is a potentially important synthon for the versatile synthesis of aminocyclitols.

Subject Keywords

Organic Chemistry, Biochemistry, Drug Discovery

URI

https://hdl.handle.net/11511/40847

Journal

TETRAHEDRON LETTERS

DOI

https://doi.org/10.1016/j.tetlet.2017.05.099

Collections

Test and Measurement Center In advanced Technologies (MERKEZ LABORATUVARI), Article

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Citation Formats

N. K. Cokol, S. Kaya, and M. BALCI, “A new synthon for the synthesis of aminoinositol derivatives,” TETRAHEDRON LETTERS, pp. 2732–2735, 2017, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/40847.