Monoclonal antibodies for targeted therapy in colorectal cancer.

Traditional therapeutic regimens of solid tumors such as chemotherapy and radiotherapy often do not distinguish between malignant and normal tissues, resulting in considerable side-effects. Monoclonal antibodies (mAbs), targeted against antigens dysregulated in cancers, have therefore generated great interest in both clinical and research settings. The antibodies are either chimeric or human(ized) and can bind to and inhibit target proteins overexpressed in both solid tumors and hematological malignancies. Some of these mAbs have shown efficacy in patients who are refractory to traditional chemotherapy. Examples of FDA approved antibodies against metastatic colorectal cancer include cetuximab, panitumumab and bevacizumab. This review summarizes the current knowledge of mAbs targeting growth factors in colorectal cancer and the importance of carefully screening patients to select candidates who will benefit most from these therapies.
Cancer biology & therapy


Synthesis of poly (dl-lactic-co-glycolic acid) coated magnetic nanoparticles for anti-cancer drug delivery
Tansık, Gülistan; Gündüz, Ufuk; Department of Biology (2012)
One of the main problems of current cancer chemotherapy is the lack of selectivity of anti-cancer drugs to tumor cells which leads to systemic toxicity and adverse side effects. In order to overcome these limitations, researches on controlled drug delivery systems have gained much attention. Nanoscale based drug delivery systems provide tumor targeting. Among many types of nanocarriers, superparamagnetic nanoparticles with their biocompatible polymer coatings can be targeted to an intented site by an extern...
Significance of genetic Polymorphisms at multiple loci of CYP2E1 in the risk of development of childhood acute lymphoblastic leukemia
Ulusoy, Gulen; Adalı, Orhan; Tumer, Tugba Boyunegmez; Sahin, Gurses; Gozdasoglu, Sevgi; Arinc, Emel (S. Karger AG, 2007-01-01)
Background/Aims: The molecular etiology of childhood acute lymphoblastic leukemia (ALL) is likely to involve interactions between environmental factors and genetic make up. Understanding these interactions between various predisposing genes for the risk of developing childhood leukemia is of considerable importance. CYP2E1 is a susceptible gene in this respect, especially for its capacity to bioactivate many procarcinogens including benzene and N-nitrosodimethylamine. The CYP2E1 gene possesses several polym...
Serum Glycan Signatures of Gastric Cancer
Özcan Kabasakal, Süreyya; Ruhaak, L. Renee; Torres, Javier; Cooke, Cara L.; An, Hyun Joo; Hua, Serenus; Williams, Cynthia C.; Dimapasoc, Lauren M.; Kim, Jae Han; Camorlinga-Ponce, Margarita; Rocke, David; Lebrilla, Carlito B.; Solnick, Jay V. (American Association for Cancer Research (AACR), 2014-02-01)
Glycomics, a comprehensive study of glycans expressed in biologic systems, is emerging as a simple yet highly sensitive diagnostic tool for disease onset and progression. This study aimed to use glycomics to investigate glycan markers that would differentiate patients with gastric cancer from those with nonatrophic gastritis. Patients with duodenal ulcer were also included because they are thought to represent a biologically different response to infection with Helicobacter pylori, a bacterial infection tha...
MTA-1 expression is associated with metastasis and epithelial to mesenchymal transition in colorectal cancer cells
Cagatay, Seda Tuncay; Cimen, Ismail; SAVAŞ, BERNA; Banerjee, Sreeparna (Springer Science and Business Media LLC, 2013-04-01)
Although metastasis associated protein 1 (MTA1) has been widely linked to tumor metastasis, the relevant mechanisms remain to be elucidated, especially in colorectal cancer (CRC). Here, we have investigated the link between MTA1, metastasis and epithelial-mesenchymal transition (EMT) in CRC. Eighteen normal colon tissues and 91 resected tumor samples were analyzed for MTA1 expression by immunohistochemistry (IHC). IHC indicated low or no nuclear MTA1 expression in the normal tissues and significantly higher...
Overexpressed genes/ESTs and characterization of distinct amplicons on 17q23 in breast cancer cells
Erson Bensan, Ayşe Elif; DEMERS, SK; ROUILLARD, JM; HANASH, SM; PETTY, EM (Elsevier BV, 2001-11-01)
17q23 is a frequent site of gene amplification in breast cancer. Several lines of evidence suggest the presence of multiple amplicons on 17q23. To characterize distinct amplicons on 17q23 and localize putative oncogenes, we screened genes and expressed sequence tags (ESTs) in existing physical and radiation hybrid maps for amplification and overexpression in breast cancer cell lines by semiquantitative duplex PCR, semiquantitative duplex RT-PCR, Southern blot, and Northern blot analyses. We identified two d...
Citation Formats
S. Banerjee, “Monoclonal antibodies for targeted therapy in colorectal cancer.,” Cancer biology & therapy, pp. 563–71, 2010, Accessed: 00, 2020. [Online]. Available: