Calcium zirconium silicate (baghdadite) ceramic as a biomaterial

Jodati, Hossein
Yilmaz, Bengi
Evis, Zafer
Bioceramics have been widely used for many years to restore and replace hard tissues including bones, teeth and mineralized matrices such as calcified cartilages at osteochondral interfaces, mainly because of their physicochemical similarity with these tissues. Calcium silicate based bioceramics have been shown to possess high bioactivity due to having high apatite-forming ability and stimulating cell proliferation, as well as biodegradability at rates appropriate to hard tissue regeneration. The outstanding biological properties of these ceramics have made them the most studied hard tissue engineering biomaterials along with calcium phosphates and bioactive glasses. Baghdadite is a calcium silicate containing zirconium ions which promotes the proliferation and differentiation of human osteoblasts and consequently increases mineral metabolism and ossification. Recently, it has attracted considerable attention in academic community and widely studied in the form of porous scaffolds, coatings, bone cement and void fillers, microspheres and nanoparticles mostly in orthopedic, dental and maxillofacial applications. This review paper is aimed to summarize and discuss the most relevant studies on the mechanical properties, apatite formation ability, dissolution behavior, and in vitro and in vivo biological properties of baghdadite as a biomaterial for hard tissue regeneration applications.


Facile control of hydroxyapatite particle morphology by utilization of calcium carbonate templates at room temperature
Oral, Çağatay M.; Çalışkan, Arda; Kapusuz, Derya; Ercan, Batur (Elsevier BV, 2020-09-01)
Hydroxyapatite (HAp, Ca-10(PO4)(6)(OH)(2)) particles are widely used in orthopedic applications due to their chemical resemblance to the inorganic component of bone tissue. Since physical and chemical properties of HAp particles influence bone regeneration, various synthesis techniques were developed to precisely control the particle properties. However, most of these techniques required high reaction temperatures, which limited the spectrum of obtained HAp particle morphologies. In this study, ellipsoidal,...
Synthesis of calcium carbonate microspheres via inert gas bubbling for orthopedic applications
Oral, Cagatay M.; Caliskan, Arda; Goctu, Yagmur; KAPUSUZ, DERYA; Ercan, Batur (Elsevier BV, 2020-02-15)
Calcium carbonate (CaCO3) microspheres consisting of vaterite polymorph have been widely used in biomedical applications. Specifically, vaterite microspheres having hollow cores showed significant potential in drug delivery, however the spontaneous transformation of vaterite to other polymorphs in aqueous environments reduced its controlled in vivo release capability. In this work, calcite and aragonite microspheres having hollow/porous inner cores were synthesized -for the first time-using sodium dodecyl s...
A review of bioceramic porous scaffolds for hard tissue applications: Effects of structural features
Jodati, Hossein; Yilmaz, Bengi; Evis, Zafer (Elsevier BV, 2020-07-01)
Tissue engineering has acquired remarkable attention as an alternative strategy to treat and restore bone defects during recent years. A scaffold is a fundamental component for tissue engineering, on which cells attach, proliferate and differentiate to form new desirable functional tissue. The composition, and structural features of scaffolds, including porosity and pore size, play a fundamental role in the success of tissue-engineered construct. This review summarizes the effect of porosity and pore size o...
Synthesis and characterization of magnesium-lanthanum dual doped bioactive glasses
Jodati, Hossein; Guner, Bahadir; Evis, Zafer; Keskin, Dilek; Tezcaner, Ayşen (Elsevier BV, 2020-06-01)
Dual ion-doped bioactive glass has drawn high attention during recent years because of well-improved therapeutic characteristics and mechanical properties. In this study, 5 different ion-doped (1 wt% Lanthanum with 0, 1, 2.5, 5, and 10 wt% Magnesium) 58S bioactive glasses (BGs) were synthesized. The physicochemical results revealed that Lanthanum (La) and Magnesium (Mg) ion doping has been successfully done. Mechanical characterization results depicted that La-doped and Mg-La double doped samples with Mg le...
Hydrothermal synthesis of Yb-doped BiFeO3 crystallites and their structural, magnetic and electrical properties
Özdilek, Çağrı (Elsevier BV, 2020-01-01)
© 2020 Elsevier Ltd and Techna Group S.r.l.The influence of Yb doping on the structural, magnetic and electrical properties of bismuth ferrite (BiFeO3) was investigated. Well-crystallized BiFeO3 (BFO) and Yb-doped BiFeO3 powders (Bi1-xYbxFeO3: x = 0, 0.03, 0.05, 0.1) were successfully synthesized via a typical hydrothermal method. X-ray diffraction (XRD) revealed that powders have a distorted rhombohedral structure with a space group of R3c. Field emission scanning electron microscope (FESEM) studies indica...
Citation Formats
H. Jodati, B. Yilmaz, and Z. Evis, “Calcium zirconium silicate (baghdadite) ceramic as a biomaterial,” CERAMICS INTERNATIONAL, pp. 21902–21909, 2020, Accessed: 00, 2020. [Online]. Available: