Synthesis and characterization of magnesium-lanthanum dual doped bioactive glasses

Jodati, Hossein
Guner, Bahadir
Evis, Zafer
Keskin, Dilek
Tezcaner, Ayşen
Dual ion-doped bioactive glass has drawn high attention during recent years because of well-improved therapeutic characteristics and mechanical properties. In this study, 5 different ion-doped (1 wt% Lanthanum with 0, 1, 2.5, 5, and 10 wt% Magnesium) 58S bioactive glasses (BGs) were synthesized. The physicochemical results revealed that Lanthanum (La) and Magnesium (Mg) ion doping has been successfully done. Mechanical characterization results depicted that La-doped and Mg-La double doped samples with Mg less than 2.5 wt% had higher diametral tensile strength compared to BG and other co-doped samples. However, Vickers hardness values were not affected by ion dopings. Apatite formation and bioactivity were also improved in double ion-doped samples, especially in those with the higher magnesium content. Cell culture studies showed that synthesized BGs were not cytotoxic. Especially, groups having 2.5 to 5 wt% Mg showed the highest cell viabilities at day 7. Results indicated that Mg- La dual doped bioactive glasses possess improved properties compared to BG, and thus, have potential for bone regeneration applications.

Citation Formats
H. Jodati, B. Guner, Z. Evis, D. Keskin, and A. Tezcaner, “Synthesis and characterization of magnesium-lanthanum dual doped bioactive glasses,” CERAMICS INTERNATIONAL, vol. 46, pp. 10503–10511, 2020, Accessed: 00, 2020. [Online]. Available: