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Addition of Selenium Nanoparticles to Electrospun Silk Scaffold Improves the Mammalian Cell Activity While Reducing Bacterial Growth
Date
2016-07-14
Author
Chung, Stanley
Ercan, Batur
Roy, Amit K.
Webster, Thomas J.
Metadata
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Silk possesses many beneficial wound healing properties, and electrospun scaffolds are especially applicable for skin applications, due to their smaller interstices and higher surface areas. However, purified silk promotes microbial growth. Selenium nanoparticles have shown excellent antibacterial properties and are a novel antimicrobial chemistry. Here, electrospun silk scaffolds were doped with selenium nanoparticles to impart antibacterial properties to the silk scaffolds. Results showed significantly improved bacterial inhibition and mild improvement in human dermal fibroblast metabolic activity. These results suggest that the addition of selenium nanoparticles to electrospun silk is a promising approach to improve wound healing with reduced infection, without relying on antibiotics.
Subject Keywords
Silk
,
Electrospinning
,
Antibacterial nanoparticles
URI
https://hdl.handle.net/11511/44332
Journal
FRONTIERS IN PHYSIOLOGY
DOI
https://doi.org/10.3389/fphys.2016.00297
Collections
Department of Metallurgical and Materials Engineering, Article
Citation Formats
IEEE
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MLA
BibTeX
S. Chung, B. Ercan, A. K. Roy, and T. J. Webster, “Addition of Selenium Nanoparticles to Electrospun Silk Scaffold Improves the Mammalian Cell Activity While Reducing Bacterial Growth,”
FRONTIERS IN PHYSIOLOGY
, vol. 7, pp. 0–0, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/44332.