Electrospun Silk Doped with Selenium for Antibacterial Skin Applications

Date

2014-01-01

Author

Chung, Stanley
Ercan, Batur
Webster, Thomas J.
Phong Tran, Phong Tran

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Skin is the largest organ by surface area and provides the primary defense against microbes, viruses, and other harmful environmental interactions. Silk is widely used as a cosmetic additive and has been investigated for skin regeneration because of its beneficial properties for skin application : promotion of collagen synthesis, re-epithelialization, wound healing, atopic dermatitis alleviation, and scar reduction. However, pure silk shows negligible or even negative antibacterial properties. Here, we propose for the first time, an electrospun silk scaffold doped with selenium to address this issue. Electrospun silk scaffolds have smaller interstices and higher surface areas, allowing for more efficient nutrient transfer to the skin. In addition, selenium nanoparticles have been shown to possess excellent antibacterial properties. By incorporating selenium nanoparticles into silk, we expect to retain silk's beneficial skin healing properties while improving its antibacterial ability.

Subject Keywords

Electrospinning, Antibacterial, Silk, Selenium nanoparticles, Skin

URI

https://hdl.handle.net/11511/37435

DOI

https://doi.org/10.1109/nebec.2014.6972758

Collections

Department of Metallurgical and Materials Engineering, Conference / Seminar

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Addition of Selenium Nanoparticles to Electrospun Silk Scaffold Improves the Mammalian Cell Activity While Reducing Bacterial Growth Chung, Stanley; Ercan, Batur; Roy, Amit K.; Webster, Thomas J. (2016-07-14) Silk possesses many beneficial wound healing properties, and electrospun scaffolds are especially applicable for skin applications, due to their smaller interstices and higher surface areas. However, purified silk promotes microbial growth. Selenium nanoparticles have shown excellent antibacterial properties and are a novel antimicrobial chemistry. Here, electrospun silk scaffolds were doped with selenium nanoparticles to impart antibacterial properties to the silk scaffolds. Results showed significantly im...
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Citation Formats

S. Chung, B. Ercan, T. J. Webster, and P. T. Phong Tran, “Electrospun Silk Doped with Selenium for Antibacterial Skin Applications,” 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/37435.