Optimization of ETV-ICP(TOF)MS and transient signal profiles for reducing isobaric interferences

Date

2005-01-01

Author

Ertaş, Gülay

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

233
views

0
downloads

One of the advantages of the ETV sample introduction is the ability to temporally separate analyte elements in complex mixtures by differences in their vaporization temperatures within the ETV for ICPMS. However, the broadening of the transient peaks in the transport tubing often obscures this temporal resolution. This study shows that decreasing the transport tubing diameter produces little broadening beyond that produced during aerosol production in the ETV. Maintaining such narrow peaks through the transport process to the ICP permits time resolution to circumvent atomic isobaric interferences. Differences in vaporization characteristics of the elements were used to resolve the isobaric overlaps among Zn, Ni, Se, Ge, Cd, In and Sn. A Monte Carlo simulation that focused on particle motion from the ETV to the plasma source was employed to evaluate the roles of diameter of transport tubing and heating rate of the ETV on signal broadening. It was shown that laminar flow broadening was reduced by decreasing the transport tubing diameter and thus more closely reflected the generation function of the ETV. However, for some elements there was as much as a 75% reduction in signal from use of the smaller, 1.5 mm i.d. tubing. There was also a trend to further improve the resolution using lower heating rates of the ETV, although the longitudinal non-isothermality of the graphite furnace broadened the peaks beyond the values expected if there was no gradient along the length of the ETV. This was more noticeable for lower heating rates, e.g., <400 degrees C s(-1). Results are presented for Monte Carlo simulations and time resolved signals obtained on an ETV-ICP(TOF)MS system.

Subject Keywords

Analytical Chemistry, Spectroscopy

URI

https://hdl.handle.net/11511/45900

Journal

JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

DOI

https://doi.org/10.1039/b505482f

Collections

Department of Chemistry, Article

Suggestions

OpenMETU
Core

Historical development of simulated body fluids used in biomedical applications: A review Yilmaz, Bengi; Pazarçeviren, Ahmet Engin; Tezcaner, Ayşen; Evis, Zafer (Elsevier BV, 2020-06-01) Simulated body fluid (SBF) is an acellular, protein-free, supersaturated calcium-phosphate solution with ionic composition nearly equal to that of human blood plasma and generally buffered at physiological conditions (pH 7.4 and 36.5 degrees C). Various SBF formulations have been used for decades to: (1) test corrosion and bone-bonding behavior, bioactivity, ion release, swelling and biodegradation rates of biomaterials and (2) deposit calcium phosphates, especially hydroxyapatite, onto the substrates of di...
Development of sensitive analytical methods for the determination of thallium at trace levels by slotted quartz tube flame atomic absorption spectrometry Ari, Betul; BAKIRDERE, Sezgin; Ataman, Osman Yavuz (Elsevier BV, 2020-09-01) A simple, sensitive and economical technique is needed for the determination of thallium and this study demonstrates the different analytical strategies were developed using atomic absorption spectrometry (AAS). In order to improve the sensitivity of flame atomic absorption spectrometry (FAAS), a basic slotted quartz tube (SQT) was used for the thallium determination. In the first strategy, mixing propanol (100 mu L) and Tl standard solution (500 mu L) under the optimum conditions, namely solvent assisted S...
MERCURY SPECIATION BY ELECTROCHEMICAL SEPARATION AND COLD-VAPOR ATOMIC-ABSORPTION SPECTROMETRY ERGUCYENER, C; AYGUN, S; Ataman, Osman Yavuz; TEMIZER, A (1988-01-01) Mercury speciation in aqueous solutions containing inorganic mercury and methylmercury has been demonstrated using electrochemical separation prior to determination by cold-vapour atomic absorption spectrometry. Approximately 95% of the inorganic mercury was electro-deposited on a Pt electrode at –0.1 V, whereas for methylmercury –0.2 V or even more negative potentials were required. Organic mercury was determined by NaBH4 reduction after electrochemical separation. Inorganic mercury was determined in the o...
On-line preconcentration of vapor forming elements on resistively heated w-coil prior to their determination by atomiz absorption spectrometry Cankur, Oktay; Ataman, Osman Yavuz; Department of Chemistry (2004) Vapor generation in atomic spectrometry is a well established technique for the determination of elements that can be volatilized by chemical reactions. In-situ trapping in graphite furnaces is nowadays one of the most popular methods to increase the sensitivity. In this study, resistively heated W-coil was used as an online trap for preconcentration and revolatilization of volatile species of Bi, Cd and Pb. The collected analyte species were revolatilized rapidly and sent to a quartz Ttube atomizer for AAS...
Introduction of solid-phase microextraction as a high-throughput sample preparation tool in laboratory analysis of prohibited substances Boyacı, Ezel; Rodriguez-Lafuente, Angel; Bojko, Barbara; Pawliszyn, Janusz (Elsevier BV, 2014-01-27) A fully automated, high-throughput method based on thin-film solid-phase microextraction (SPME) and liquid chromatography-mass spectrometry was developed for simultaneous quantitative analysis of 110 doping compounds, selected from ten classes and varying in physical and chemical properties. Among four tested extraction phases, C18 blades were chosen, as they provided optimum recoveries and the lowest carryover effect. The SPME method was optimized in terms of extraction pH, ionic strength of the sample, wa...

Citation Formats

G. Ertaş, “Optimization of ETV-ICP(TOF)MS and transient signal profiles for reducing isobaric interferences,” JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, pp. 687–695, 2005, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/45900.