Kanser hedefleme ve terapi için 2-deoksi-D-gilikoz (2-DG)-etiketli kobalt ferrit (CoFe2O4)manyetik nanoparçacıklar

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Date

2014

Author

Işık, Elif
Güray, Nülüfer Tülün
Volkan, Mürvet

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In this study, strong magnetic featured silica coated Cobalt ferrite (CoFe204) nanoparticles were labeled with 2-deoxy glucose (2-DG) for better targetting to cancer cells and the molecular effects of these prepared magnetic nanoparticles (MNPs) were investigated in cancer cell lines. In this study, in vitro characterization of 2-DG labelled MNPs were carried out in breast cancer cells (MDA-MB-231 breast cancer and normal cell MCF10A), and cellular uptake mechanisms, genotoxicity, intracellular levels of oxidative stress and stress-related autophagic, apoptotic pathways, mRNA expression profiles of some key genes in different biological pathways were studied. Further development of multifunctional different carrier systems for cancer teraphies with nanotechnological view is one of the popular and privileged area. Thus, the information obtained in this study will contribute to create new therapeutic strategies and to set ground to new studies.

Subject Keywords

Nanoparticles, MNPs, Cobalt ferrite, 2-deoxyglucose, Cancer

URI

https://app.trdizin.gov.tr/publication/project/detail/TVRRMU9ETXo
https://hdl.handle.net/11511/49918

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Department of Biology, Project and Design

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Citation Formats

E. Işık, N. T. Güray, and M. Volkan, “Kanser hedefleme ve terapi için 2-deoksi-D-gilikoz (2-DG)-etiketli kobalt ferrit (CoFe2O4)manyetik nanoparçacıklar,” 2014. Accessed: 00, 2020. [Online]. Available: https://app.trdizin.gov.tr/publication/project/detail/TVRRMU9ETXo.