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Concentration dependent different action of progesterone on the order, dynamics and hydration states of the head group of dipalmitoyl-phosphatidylcholine membrane
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10.1155:2005:641043.pdf
Date
2005
Author
Korkmaz, Filiz
Kirbiyik, Halil
Severcan, Feride
Metadata
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Interactions of progesterone with zwitterionic dipalmitoyl phosphatidylcholine (DPPC) multilamellar liposomes (MLVs) were investigated as a function of progesterone concentration at selected temperatures monitoring both the gel and liquid crystalline phase, by using Fourier Transform Infrared spectroscopy (FTIR). It has been show that the effect of progesterone on membrane dynamics is dependent on progesterone concentration. At 1 mol%, which is close to physiological level, progesterone behaves differently. At this concentration the decrease in dynamics is more noticeable. Additionally a dramatic decrease in the strength of hydrogen bonding in the interfacial region of the bilayer is also observed. When concentration increases up to 12 mol% opposite behaviour is observed at all interactions. Above 12 mol%, progesterone–DPPC interactions shows almost linear plot.
Subject Keywords
DPPC liposome
,
Progesterone
,
FTIR
,
Membrane fluidity
,
Lipid order
URI
https://hdl.handle.net/11511/51738
Journal
Spectroscopy
DOI
https://doi.org/10.1155/2005/641043
Collections
Department of Biology, Article