Oestrogen phospholipid membrane interactions: An FTIR study

Date

1997-06-01

Author

Boyar, H
Severcan, Feride

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

243
views

0
downloads

Interactions of 17 beta-oestradiol (E2) with dipalmitoyl phosphatidylcholine (DPPC) multilamellar liposomes were investigated by Fourier transform infrared (FTIR) spectroscopy as a function of temperature. The investigation of the C-H stretching region and the C=0 mode reveals that E2 changes the physical properties of the DPPC bilayers by decreasing the main phase transition temperature, diminishing the pretransition, slightly disordering the system in the gel and in the liquid crystalline phase, increasing the dynamics of the system in the gel phase, and making strong hydrogen bonding with the C=0 groups of DPPC in the liquid crystalline phase. (C) 1997 Elsevier Science B.V.

Subject Keywords

Oestrogen, 17 beta-oestradiol, DPPC, Phospholipid membrane, Model membrane, Membrane fluidity, FTIR spectroscopy

URI

https://hdl.handle.net/11511/57881

Journal

JOURNAL OF MOLECULAR STRUCTURE

DOI

https://doi.org/10.1016/s0022-2860(96)09535-x

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

Tamoxifen-model membrane interactions: An FT-IR study Boyar, H; Severcan, Feride (1997-06-01) The temperature- and concentration-induced effects of tamoxifen (TAM) on dipalmitoyl phosphatidylcholine (DPPC) model membranes were investigated by the Fourier transform-infrared (FT IR) spectroscopic technique. An investigation of the C-H stretching region and the C=0 mode reveals that the inclusion of TAM changes the physical properties of the DPPC multibilayers by (i) shifting the main phase transition to lower temperatures; (ii) broadening the transition profile slightly; (iii) disordering the system i...
Concentration dependent different action of progesterone on the order, dynamics and hydration states of the head group of dipalmitoyl-phosphatidylcholine membrane Korkmaz, Filiz; Kirbiyik, Halil; Severcan, Feride (Hindawi Limited, 2005) Interactions of progesterone with zwitterionic dipalmitoyl phosphatidylcholine (DPPC) multilamellar liposomes (MLVs) were investigated as a function of progesterone concentration at selected temperatures monitoring both the gel and liquid crystalline phase, by using Fourier Transform Infrared spectroscopy (FTIR). It has been show that the effect of progesterone on membrane dynamics is dependent on progesterone concentration. At 1 mol%, which is close to physiological level, progesterone behaves differently....
Biophysical studies of progesterone-model membrane interactions Korkmaz, Filiz; Kırbıyık, Halil; Severcan, Feride; Department of Physics (2003) Interactions of progesterone with zwitterionic dipalmitoyl phosphotidylcholine (DPPC) multilamellar liposomes (MLVs) were investigated as a function of temperature and progesterone concentration by using three non-invasive techniques of Fourier transform infrared (FTIR) spectroscopy, turbidity at 440 nm and differential scanning calorimetry (DSC).The results show that lmol% of progesterone does not induce a significant change in the shape of thermotropic profile of DPPC. However as progesterone concentratio...
Competitive effect of vitamin D-2 and Ca2+ on phospholipid model membranes: an FTIR study Toyran, N; Severcan, Feride (2003-04-01) The interaction of Ca2+, with dipalmitoyl phosphatidylcholine (DPPC) model membranes was studied in the presence and absence of vitamin D-2 by using Fourier transform infrared spectroscopy. Addition of vitamin D-2 and/or Ca2+ into pure DPPC liposomes shifts the phase transition to higher temperature, orders and decreases the dynamics of the acyl chains in both phases and does not induce hydrogen bond formation in the interfacial region. Moreover, the dynamics of the head group of the phospholipid decreases ...
Effects of the non-steroidal anti-inflammatory drug celecoxib on cholesterol containing distearoyl phosphatidylcholine membranes Sade, Asli; Banerjee, Sreeparna; Severcan, Feride (2011-01-01) The effects of different concentrations of celecoxib on the acyl chain order, dynamics and the hydration status of the head group and interfacial region of model membranes containing DSPC and cholesterol were investigated in detail using Fourier transform infrared spectroscopy. Our results reveal that regardless of the presence of cholesterol, celecoxib is able to alter the physical properties of membranes. It exerts opposing effects on membrane order at high and low concentrations and decreases membrane fl...

Citation Formats

H. Boyar and F. Severcan, “Oestrogen phospholipid membrane interactions: An FTIR study,” JOURNAL OF MOLECULAR STRUCTURE, pp. 269–272, 1997, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/57881.