Tamoxifen-model membrane interactions: An FT-IR study

Date

1997-06-01

Author

Boyar, H
Severcan, Feride

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The temperature- and concentration-induced effects of tamoxifen (TAM) on dipalmitoyl phosphatidylcholine (DPPC) model membranes were investigated by the Fourier transform-infrared (FT IR) spectroscopic technique. An investigation of the C-H stretching region and the C=0 mode reveals that the inclusion of TAM changes the physical properties of the DPPC multibilayers by (i) shifting the main phase transition to lower temperatures; (ii) broadening the transition profile slightly; (iii) disordering the system in the gel and in the liquid crystalline phases; (iv) increasing the dynamics in the gel phase and decreasing the dynamics of the acyl chains in the liquid crystalline phase; (v) increasing the mobility of the terminal methyl group region of the bilayer in the gel phase and decreasing it in the liquid crystalline phase; (vi) increasing the frequency of the C=0 stretching mode both in the gel and in the liquid crystalline phases, i.e. non-bonding with carbonyl groups. (C) 1997 Elsevier Science B.V.

Subject Keywords

Tamoxifen, DPPC, Phospholipid membrane, Model membrane, Membrane fluidity, FT-IR spectroscopy

URI

https://hdl.handle.net/11511/51820

Collections

Department of Biology, Article