BOSENTAN, A NON-SPECIFIC ENDOTHELIN ANTAGONIST, STIMULATES FRACTURE HEALING

2007-02-01
Muratli, Hasan H.
Korkusuz, Feza
KORKUSUZ, PETEK
Bicimoglu, Ali
Ercan, Z. Sevim
Show full item record
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
109
views
0
downloads
It is assumed that bosentan, a non-selective ET-1 receptor antagonist, will enhance fracture healing. The aim of this prospective randomized controlled study was to investigate the effects of transcutaneous bosentan administration into diaphyseal bone fractures using radiology, histology, prostaglandin E-2 (PGE(2)) and leukotrien C-4 (LTC4) activity measurements.
Biophysics, Bioengineering, Biomedical Engineering
https://hdl.handle.net/11511/51900
BIOMEDICAL ENGINEERING-APPLICATIONS BASIS COMMUNICATIONS
Department of Physical Education and Sports, Article

Suggestions

In vitro and in vivo evaluation of the effects of demineralized bone matrix or calcium sulfate addition to polycaprolactone-bioglass composites
ERDEMLİ, ÖZGE; Captug, O.; Bilgili, H.; ORHAN, DİCLEHAN; Tezcaner, Ayşen; Keskin, Dilek (Springer Science and Business Media LLC, 2010-01-01)
The objective of this study was to improve the efficacy of polycaprolactone/bioglass (PCL/BG) bone substitute using demineralized bone matrix (DBM) or calcium sulfate (CS) as a third component. Composite discs involving either DBM or CS were prepared by compression moulding. Bioactivity of discs was evaluated by energy dispersive X-ray spectroscopy (ESCA) and scanning electron microscopy (SEM) following simulated body fluid incubation. The closest Calcium/Phosphate ratio to that of hydroxyl carbonate apatit...
Resorbable PCEC/gelatin-bismuth doped bioglass-graphene oxide bilayer membranes for guided bone regeneration
Pazarçeviren, Ahmet Engin; Evis, Zafer; Keskin, Dilek; Tezcaner, Ayşen (IOP Publishing, 2019-05-01)
Guided bone regeneration (GBR) is a therapeutic modality applied prior to dental implant placement to increase bone density at the defect site or during placement for directing bone growth around implant. In this study, an asymmetric, bilayer structure was prepared by covalently bonding a dense polycaprolactone-polyethylene glycol-polycaprolactone (PCEC) membrane layer with a hydrogel layer composed of bismuth doped bioactive glass (BG, 45S5) and graphene oxide (GO) particles incorporated in gelatin. Struct...
Computational analysis for non-invasive detection of stenosis in peripheral arteries
Salman, Huseyin Enes; Yazıcıoğlu, Yiğit (Elsevier BV, 2019-08-01)
Atherosclerosis usually affects the entire cardiovascular system, including peripheral blood vessels. Peripheral arterial stenosis may indicate possible serious vascular disorders related to more vital organs. If peripheral arterial stenosis can be discerned at an early stage, it can serve as a warning sign to take precautions, such as using more invasive diagnostic techniques or adopting a healthier life style. In this study, peripheral regions, such as the thigh, upper arm, and neck are modelled consideri...
Dual growth factor delivery using PLGA nanoparticles in silk fibroin/PEGDMA hydrogels for articular cartilage tissue engineering
Fathi-Achachelouei, Milad; Keskin, Dilek; Bat, Erhan; Vrana, Nihal E.; Tezcaner, Ayşen (Wiley, 2020-07-01)
Degeneration of articular cartilage due to damages, diseases, or age-related factors can significantly decrease the mobility of the patients. Various tissue engineering approaches which take advantage of stem cells and growth factors in a three-dimensional constructs have been used for reconstructing articular tissue. Proliferative impact of basic fibroblast growth factor (bFGF) and chondrogenic differentiation effect of transforming growth factor-beta 1 (TGF-beta 1) over mesenchymal stem cells have previou...
Immobilization of glucose oxidase onto gelatin for biosensor construction
Emregul, E; Sungur, S; Akbulut, Ural (Informa UK Limited, 2005-01-01)
The properties of a glucose biosensor made by immobilization of glucose oxidase onto gelatin in a layer of electrochemically deposited polyaniline have been investigated. Glucose oxidase was immobilized within gelatin cross-links with chromium(III) acetate. The glucose oxidase biosensor was developed by forming a polyaniline-deposited electrode surface as support for the immobilized enzyme gel, in order to increase its durability. The polyaniline/gelatin/glucose oxidase biosensor has been characterized usin...
Citation Formats
H. H. Muratli, F. Korkusuz, P. KORKUSUZ, A. Bicimoglu, and Z. S. Ercan, “BOSENTAN, A NON-SPECIFIC ENDOTHELIN ANTAGONIST, STIMULATES FRACTURE HEALING,” BIOMEDICAL ENGINEERING-APPLICATIONS BASIS COMMUNICATIONS, pp. 37–46, 2007, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/51900.
METU IIS - Integrated Information Service open@metu.edu.tr