LABEL-FREE DETECTION OF LEUKEMIA CELLS WITH A LAB-ON-A-CHIP SYSTEM INTEGRATING DIELECTROPHORESIS AND CMOS IMAGING

Date

2015-06-25

Author

Demircan, Y.
Orguc, S.
Musayev, J.
Ozgur, E.
Erdem, Murat
Gündüz, Ufuk
Eminoglu, S.
Külah, Haluk
Akın, Tayfun

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This paper presents a fully-integrated lab-on-a-chip (LOC) system for label-free detection and real-time counting of dielectrophoretically trapped multidrug resistant (MDR) K562 cells. The system integrates a parylene-based microfluidic DEP channel on top of a CMOS image sensor for the first time in the literature. The DEP channel can trap MDR K562 cells with 9 V-pp and 10 mu l/min flow rate, and the CMOS image sensor can detect the trapped cells as small as 3 mu m in diameter with a noise level of 28.3 e(-)rms.

Subject Keywords

Lab-on-a-chip (LOC), Dielectrophoresis (DEP), CMOS, Multidrug resistance (MDR), Label-free

URI

https://hdl.handle.net/11511/55275

Collections

Department of Biology, Conference / Seminar

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Citation Formats

Y. Demircan et al., “LABEL-FREE DETECTION OF LEUKEMIA CELLS WITH A LAB-ON-A-CHIP SYSTEM INTEGRATING DIELECTROPHORESIS AND CMOS IMAGING,” 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/55275.