Structure-function of cytochromes P450 and flavin-containing monooxygenases - Implications for drug metabolism

Date

1998-12-01

Author

Halpert, JR
Domanski, TL
Adalı, Orhan
Biagini, CP
Cosme, J
Dierks, EA
Johnson, EF
Jones, JP
de Montellano, PO
Philpot, RM
Sibbesen, O
Wyatt, WK
Zheng, ZP

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This article is a report on a symposium held at Experimental Biology '98 in San Francisco, California. Recent developments in site-directed mutagenesis, computer-modeling, and mechanistic analysis of cytochromes P450 and flavin-containing monooxygenases are described. A unifying theme is the elaboration of general approaches for understanding and predicting the function of individual forms of these enzymes. A related goal is the production of soluble forms of mammalian cytochromes P450 for X-ray crystallography.

Subject Keywords

Site-directed mutagenesis, Trypanothione reductase, Substrate-specificity, Glutathione-reductase, Catalytic mechanism, Primary alkylamines, Escherichia-coli, Amino-acid, Protein, Binding

URI

https://hdl.handle.net/11511/55596

Journal

DRUG METABOLISM AND DISPOSITION

Collections

Department of Biology, Article

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Citation Formats

J. Halpert et al., “Structure-function of cytochromes P450 and flavin-containing monooxygenases - Implications for drug metabolism,” DRUG METABOLISM AND DISPOSITION, pp. 1223–1231, 1998, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/55596.