Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Structure-function of cytochromes P450 and flavin-containing monooxygenases - Implications for drug metabolism
Date
1998-12-01
Author
Halpert, JR
Domanski, TL
Adalı, Orhan
Biagini, CP
Cosme, J
Dierks, EA
Johnson, EF
Jones, JP
de Montellano, PO
Philpot, RM
Sibbesen, O
Wyatt, WK
Zheng, ZP
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
49
views
0
downloads
Cite This
This article is a report on a symposium held at Experimental Biology '98 in San Francisco, California. Recent developments in site-directed mutagenesis, computer-modeling, and mechanistic analysis of cytochromes P450 and flavin-containing monooxygenases are described. A unifying theme is the elaboration of general approaches for understanding and predicting the function of individual forms of these enzymes. A related goal is the production of soluble forms of mammalian cytochromes P450 for X-ray crystallography.
Subject Keywords
Site-directed mutagenesis
,
Trypanothione reductase
,
Substrate-specificity
,
Glutathione-reductase
,
Catalytic mechanism
,
Primary alkylamines
,
Escherichia-coli
,
Amino-acid
,
Protein
,
Binding
URI
https://hdl.handle.net/11511/55596
Journal
DRUG METABOLISM AND DISPOSITION
Collections
Department of Biology, Article
Suggestions
OpenMETU
Core
The response of periphyton and submerged macrophytes to nitrogen and phosphorus loading in shallow warm lakes: a mesocosm experiment
Özkan, Korhan; Johansson, Liselotte S.; Beklioğlu, Meryem (2010-02-01)
1. Recent experimental and field studies on temperate shallow lakes indicate that nitrogen may play a greater role in their functioning than previously thought. Several studies document that abundance and richness of submerged macrophytes, both central in shallow lake ecology, may decrease with increasing nitrogen loading, especially at high phosphorus levels. However, the role of nitrogen in warm lakes with fluctuating water regimes remains to be described in detail.
Purification and characterization of Hexokinase isoenzymes from Rhizopus oryzae
Dedeoğlu, Didem; Hamamcı, Haluk; Department of Biotechnology (2007)
Glycolysis is the central metabolic pathway for living organisms. Its regulation is important for the yield of the end products which are industrially important. These end products, like lactic acid produced by Rhizopus oryzae, are industrially important. Rhizopus oryzae is a filamentous fungus producing lactic acid and ethanol. The lactic acid yield of R. oryzae is low (70 %) compared to that of lactic acid bacteria (95 %) still it is noteworthy because R. oryzae produces only the L (+) form of lactic acid...
Purification and characterization of cytoplasmic and proteasome associated chymotrypsin-like proteases from Thermoplasma volcanium
Özdemir, F. İnci; Kocabıyık, Semra; Department of Biology (2003)
In this study, two novel cytoplasmic serine proteases were isolated and characterized from thermophilic archaea Thermoplasma volcanium. The first protease was purified by ion exchange and affinity chromatographies and identified as a chymotrypsin-like serine protease mainly based on its substrate profile and inhibition pattern. The presence of protease activity was analyzed by gelatin zymography which was detected as a single band (35 kDa). Optimum temperature was found to be 60oC for azocasein hydrolysis a...
Detection and characterization of plant genes involved in various biotic and abiotic stress conditions using ddrt-pcr and isolation of interacting proteins
Ünver, Turgay; Akkaya, Mahinur S.; Department of Biotechnology (2008)
The main objective of this thesis dissertation is functionally characterizing the genes involved in biotic and abiotic stresses of plants at molecular level. Previously, upon pathogen attack Rad6 gene expression was found to be changed in wheat and barley plants. To functionally characterize the Rad6 gene, VIGS (Virus induced gene silencing) system was used. HR (Hypersensitive response) like symptoms was detected in every silenced barley and wheat plants. To figure out, transcriptomes and proteomes of Rad6 ...
Identification of functionally orthologous protein groups in different species based on protein network alignment
Yaveroğlu, Ömer Nebil; Can, Tolga; Department of Computer Engineering (2010)
In this study, an algorithm named ClustOrth is proposed for determining and matching functionally orthologous protein clusters in different species. The algorithm requires protein interaction networks of the organisms to be compared and GO terms of the proteins in these interaction networks as prior information. After determining the functionally related protein groups using the Repeated Random Walks algorithm, the method maps the identified protein groups according to the similarity metric defined. In orde...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
J. Halpert et al., “Structure-function of cytochromes P450 and flavin-containing monooxygenases - Implications for drug metabolism,”
DRUG METABOLISM AND DISPOSITION
, pp. 1223–1231, 1998, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/55596.