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Structure-function of cytochromes P450 and flavin-containing monooxygenases - Implications for drug metabolism
Date
1998-12-01
Author
Halpert, JR
Domanski, TL
Adalı, Orhan
Biagini, CP
Cosme, J
Dierks, EA
Johnson, EF
Jones, JP
de Montellano, PO
Philpot, RM
Sibbesen, O
Wyatt, WK
Zheng, ZP
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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This article is a report on a symposium held at Experimental Biology '98 in San Francisco, California. Recent developments in site-directed mutagenesis, computer-modeling, and mechanistic analysis of cytochromes P450 and flavin-containing monooxygenases are described. A unifying theme is the elaboration of general approaches for understanding and predicting the function of individual forms of these enzymes. A related goal is the production of soluble forms of mammalian cytochromes P450 for X-ray crystallography.
Subject Keywords
Site-directed mutagenesis
,
Trypanothione reductase
,
Substrate-specificity
,
Glutathione-reductase
,
Catalytic mechanism
,
Primary alkylamines
,
Escherichia-coli
,
Amino-acid
,
Protein
,
Binding
URI
https://hdl.handle.net/11511/55596
Journal
DRUG METABOLISM AND DISPOSITION
Collections
Department of Biology, Article
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J. Halpert et al., “Structure-function of cytochromes P450 and flavin-containing monooxygenases - Implications for drug metabolism,”
DRUG METABOLISM AND DISPOSITION
, pp. 1223–1231, 1998, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/55596.