Development of Non-Invasive and Biocompatible Thin Film Micro-Extraction Contact Lens Type Devices Compatible for In Vivo Metabolomics Investigations from Eye Surface

Nalbant, Atakan Arda
Boyacı, Ezel
Solid phase microextraction (SPME), is a sampling and samp- le preparation technique in which the extraction of analytes is based on an equilibrium established between a sample and ext- ractive phase coated on a tip of a fiber. Thin film microextraction (TFME) which is a type of SPME provides high analytical sen- sitivity in environmental and biological samples and has gained interest in areas where no other technique can provide solutions. In this study, the aim was to develop biocompatible and flexib- le contact lens shaped thin film extractive membranes applicab- le to in vivo investigations with the ultimate goal of using them for small molecule sampling from eye surface. To make them suitable for sampling from the eye surface, the membranes are synthesized with polydimethylsiloxane (PDMS) using special templates. These extractive lenses are modified with various functional moieties to enhance their extraction coverage for polar and nonpolar analytes. Afterward, the membranes are tested for their extraction performances with in vitro test model. The small molecules (‹1500 Da) extracted from this model are separated by gas chromatography and liquid chromatography and detected by mass spectrometry (MS).
Euroanalysis 2019, (1 - 05 September 2019)


Preparation, modification, and characterization of acrylic cements
Basgorenay, B; Ulubayram, K; Serbetci, K; Onurhan, E; Hasırcı, Nesrin (2006-03-15)
Acrylic cements with different compositions were prepared by mixing the solid part (composed of poly(methyl methacrylate), PMMA, and benzoyl peroxide, BPO) and the liquid part (composed of methyl methacrylate, MMA, and N,N-dimethyl-p-toluidine, DMPT), modified by addition of hydroxyapatite (HA) and ammonium nitrate (AN) and characterized by measuring thermal and mechanical properties. Three sets of samples were prepared. For B-group, the total amount of solid including HA was constant but the PMMA to HA rat...
Development of polycarbonate based zeolite 4A filled mixed matrix gas separation membranes
SEN, Deger; Kalıpçılar, Halil; Yılmaz, Levent (2007-10-15)
The incorporation of fillers, blending with multifunctional low molecular-weight additives and their combination are investigated as alternatives for modifying the permselective properties of polymeric gas separation membranes. For this purpose, pure polycarbonate (PC), PC/p-nitroaniline (pNA), PC/zeolite 4A and PC/pNA/zeolite 4A mixed matrix membranes were prepared by solvent-evaporation method using dichloromethane as solvent. Zeolite 4A was the filler and pNA was the low molecular-weight additive with mu...
The synthesis of zinc, chloride and fluoride doped nano hydroxylapatites by precipitation method and investigation of their mechanical, structural and biological properties
Uysal, İdil; Evis, Zafer; Severcan, Feride; Department of Biomedical Engineering (2011)
This study aimed synthesizing hydroxylapatite (HA) and Zn2+, F- and Cl- doped HA by solution precipitation method. The synthesized compounds were sintered at 1100°C for 1h. For structural characterization, density of the samples were measured by Archimedes’ method. It was observed that Zn2+ addition increased the density significantly whereas F- caused a decrease and Cl- increased the density with a little amount. XRD was applied to the samples and it was found that co-doping of Zn2+ and F- ions decreased t...
Preparation and thermal characterization of poly(2-vinylpyridine) copolymers coordinated to Cr nanoparticles
Öztürk, Yurdagül; Kayran, Ceyhan; Hacaloğlu, Jale (2015-06-01)
In this study, polystyrene-block-poly(2-vinylpyridine), PS-b-P2VP, polyisoprene-block-poly(2-vinylpyridne), PI-b-P2VP and poly(methyl metacrylate)-block-poly(2-vinylpyridine), PMMA-b-P2VP, coordinated to Cr metal were synthesized and characterized by Fourier transform infrared, transmission electron microscopy and direct pyrolysis mass spectrometry techniques. Both thermal degradation mechanism and thermal stability of P2VP blocks were affected by the coordination of Cr nanoparticles to nitrogen of pyridine...
Direct hydrothermal synthesis of palladium-incorporated silicate-structured mesoporous catalysts
Sener, Canan; Doğu, Timur; Dogu, Guelsen (2007-01-01)
Pd-Si-structured novel mesoporous nanocomposite catalytic materials, having quite high Pd/Si ratios, were synthesized by an acidic direct hydrothermal synthesis route. The nanocomposite catalytic materials were then characterized by XRD, XPS, EDS, nitrogen adsorption, and SEM techniques. Unlike MCM-41, the XRD patterns indicated a rather wide d((100)) band at a 2 theta value of about 1.9. The materials, with very high Pd/Si wt ratios between 1.43 and 2.66, were synthesized and had BJH surface area values be...
Citation Formats
A. A. Nalbant and E. Boyacı, “Development of Non-Invasive and Biocompatible Thin Film Micro-Extraction Contact Lens Type Devices Compatible for In Vivo Metabolomics Investigations from Eye Surface,” presented at the Euroanalysis 2019, (1 - 05 September 2019), İstanbul, Türkiye, 2019, Accessed: 00, 2021. [Online]. Available: