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Studies of enzymes that cause resistance to aminoglycosides antibiotics.
Date
2008-01-01
Author
Serpersu, Engin H
Özen, Can
Wright, Edward
Metadata
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Aminoglycoside antibiotics are highly potent, wide-spectrum bactericidals (1, 2). Bacterial resistance to aminoglycosides, however, is a major problem in the clinical use of aminoglycosides. Enzymatic modification of aminoglycosides is the most frequent resistance mode among several resistance mechanisms employed by resistant pathogens (1,3). Three families of aminoglycoside modifying enzymes, O-phosphotransferases, N-acetyltransferases, and N-nucleotidyltransferases, are known to have more than 50 enzymes (1,3,4). In this chapter, determination of enzymatic activity of a single enzyme from each family in the presence and absence of an inhibitor is described.
Subject Keywords
Antibiotic resistance
,
Drug design
,
Enzyme inhibition
,
Aminoglycoside phosphotransferase
,
Aminoglycoside nucleotidyltransferase
,
Aminoglycoside acetyltransferase
,
Aminoglycosides
URI
https://hdl.handle.net/11511/57635
Journal
Methods in molecular medicine
DOI
https://doi.org/10.1007/978-1-59745-246-5_20
Collections
Graduate School of Natural and Applied Sciences, Article