EFFECT OF 15-LIPOXYGENASE -1 (15-LOX-1) EXPRESSION ON ANGIOGENESİS IN COLORECTAL CANCER HCT-116 CELL LINES

Mechanism of Inhibition of CYP1A1 and Glutathione S-Transferase Activities in Fish Liver by Quercetin, Resveratrol, Naringenin, Hesperidin, and Rutin Arinc, Emel; Yilmaz, Duygu; BOZCAARMUTLU, AZRA (2015-01-02) Quercetin, resveratrol, naringenin, hesperidin, and rutin are phenolic compounds/flavonoids that may have roles in the reduction of cancer susceptibility. In this study, in vitro modulatory effects of them were studied on liver CYP1A1 associated 7-ethoxyresorufin-O-deethylase (EROD) activity and glutathione S-transferase (GST) activity of leaping mullet (Liza saliens). All of the phenolic compounds/flavonoids used exerted an inhibitory effect on both EROD and GST activities of fish. Quercetin, resveratrol, ...
Effect of doxorubicin on telomerase activity and apoptotic gene expression in doxorubicin-resistant and -sensitive MCF-7 cells Eskiocak, Ugur; Iseri, Ozlem Darcansoy; Kars, Meltem Demirel; Bicer, Atilla; Gündüz, Ufuk (2008-01-01) Background: Dose-and time-dependent effects of doxorubicin on telomerase activity ( TA) and expression levels of hTERT, Bcl-2, Bcl-x(L) and Bax were investigated in doxorubicin-resistant and -sensitive MCF-7 cells. Methods: Doxorubicin-resistant MCF-7/R was developed from sensitive MCF-7 breast carcinoma cell line and acquired resistance was demonstrated by XTT and mRNA analysis of MDR1 and MRP1 genes. Expression levels were determined by RT-PCR. Newly developed rapid and simple TRAP-silver staining assay w...
Interplay between 15-lipoxygenase-1 and metastasis-associated antigen 1 in the metastatic potential of colorectal cancer Tuncer, S.; ÇAĞATAY, SİBEL; Keskus, A. G.; Colakoglu, M.; KONU KARAKAYALI, ÖZLEN; Banerjee, Sreeparna (2016-08-01) ObjectivesMetastasis-associated antigen 1 (MTA1) is implicated in metastasis while 15-lipoxygenase-1 (15-LOX-1) reduces cell motility, when re-expressed in colorectal cancer (CRC). We aimed to understand any potential interplay between MTA1 and 15-LOX-1 in CRC metastasis.
Differential oncogene-related gene expressions in myeloma cells resistant to prednisone and vincristine Mutlu, Pelin; Gündüz, Ufuk (2012-10-01) Multidrug resistance in cancer may arise due to alterations in gene expression. In this study, sublines of drug-resistant multiple myeloma (MM) cells, namely RPMI-8226 and U-266, were examined for their differential oncogene-related gene expression levels and the relations to drug resistance were analyzed. Drug resistance was induced by application of the prednisone or vincristine using stepwise dose increments. XTT cytotoxicity assay was used for determination of resistance levels. Microarray analysis was ...
Effect of cobalt-60 (gamma radiation) on multidrug-resistant multiple myeloma cell lines Mutlu, Pelin; Ural, A. Ugur; Avcu, Ferit; Dirican, Bahar; Beyzadeoglu, Murat; Gündüz, Ufuk (2011-07-01) Emergence of resistance to chemotherapy and radiotherapy is a major obstacle for the successful treatment of MM (multiple myeloma). Prednisone, vincristine and melphalan are commonly used chemotherapeutic agents for the treatment of MM. In the current study, we examined the presence of possible cross-resistance between these drugs and gamma (gamma) radiation. Prednisone, vincristine and melphalan resistant RPMI-8226 and U-266 MM cells were generated by stepwise increasing concentrations of the drugs. The se...

Citation Formats

S. Banerjee, “EFFECT OF 15-LIPOXYGENASE -1 (15-LOX-1) EXPRESSION ON ANGIOGENESİS IN COLORECTAL CANCER HCT-116 CELL LINES,” 2013. Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/60068.