NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage

Date

2016-09-01

Author

Kleinschnitz, Christoph
Mencl, Stine
Kleikers, Pamela W. M.
Schuhmann, Michael K.
Lopez, Manuela G.
Casas, Ana I.
Sürün, Bilge
Reif, Andreas
Schmidt, Harald H. H. W.

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Promising results have been reported in preclinical stroke target validation for pharmacological principles that disrupt the N-methyl-D-aspartate receptor-post-synaptic density protein-95-neuronal nitric oxide synthase complex. However, post-synaptic density protein-95 is also coupled to potentially neuroprotective mechanisms. As post-synaptic density protein-95 inhibitors may interfere with potentially neuroprotective mechanisms and sufficient validation has often been an issue in translating basic stroke research, we wanted to close that gap by comparing post-synaptic density protein-95 inhibitors with NOS1(-/-) mice and a NOS inhibitor. We confirm the deleterious role of NOS1 in stroke both invivo and invitro, but find three pharmacological post-synaptic density protein-95 inhibitors to be therapeutically ineffective.

Subject Keywords

Neurology, Clinical Neurology, Cardiology and Cardiovascular Medicine

URI

https://hdl.handle.net/11511/63052

Journal

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

DOI

https://doi.org/10.1177/0271678x16657094

Collections

Graduate School of Informatics, Article

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Citation Formats

C. Kleinschnitz et al., “NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage,” JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, pp. 1508–1512, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/63052.