Biomimetic preparation of HA precursors at 37 degrees C in urea- and enzyme urease-containing synthetic body fluids

Date

1999-12-01

Author

Bayraktar, D
Tas, AC

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An important inorganic phase of synthetic bone applications, calcium hydroxyapatite (HA, Ca-10(PO4)(6)(OH)(2)), was prepared as a single-phase and sub-micron bioceramic powder. Carbonated HA precursors were synthesized from calcium nitrate tetrahydrate and diammonium hydrogen phosphate salts dissolved in "synthetic body fluid" (SBF) solutions, containing urea (H2NCONH2) and enzyme urease, under the biomimetic conditions of 37 degrees C and pH 7.4, by using a novel chemical precipitation technique.

Subject Keywords

Sintering behavior, Calcium-phosphate, Hydroxyapatite, Precipitation

URI

https://hdl.handle.net/11511/64716

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Department of Metallurgical and Materials Engineering, Conference / Seminar

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Chemical preparation of carbonated calcium hydroxyapatite powders at 37 degrees C in urea-containing synthetic body fluids Bayraktar, D; Tas, AC (1999-01-01) An important inorganic phase of synthetic bone applications, calcium hydroxyapatite (HA, Ca-10(PO4)(6)(OH)(2)), was prepared as a single-phase ceramic powder. Carbonated HA powders were formed from calcium nitrate tetrahydrate and diammonium hydrogen phosphate salts dissolved in aqueous 'synthetic body fluid' (SBF) solutions, containing urea (H2NCONH2), at 37 degrees C and pH of 7.4, by using a novel chemical precipitation technique. These powders were also found to contain trace amounts of Na and Mg impuri...
Hydrothermal synthesis of hydroxyapatite from calcium sulfate hemihydrate Bıngol, Onur Rauf; Durucan, Caner (2012-08-01) Commercial grade calcium sulfate hemihydrate (CaSO4·0.5H2O, or plaster of paris, PoP) an economically feasible and abundant precursor has been used in (Ca10(PO4)6(OH)2, HAp) synthesis. The synthesis was realized by reacting solid PoP precursor with 1M of (NH4)2HPO4 aqueous solution, at ambient and mild hydrothermal conditions (2 ± 0.2 atm and 120 °C). The effect of reaction temperature and pressure on PoP to HAp conversion efficiencies and reaction kinetics has been reported. The formation of HAp at a react...
Fabrication and characterization of porous hydroxyapatite and biphasic calcium phosphate ceramic as bone substitutes Koc, N; Timucin, M; Korkusuz, Feza (2004-01-01) In the present study, the calcium phosphate powders (HAP, HAP-TCP) were produced by a precipitation technique involving the use of aqueous solutions of calcium nitrate and diammonium hydrogen phosphate. Preforms of calcium phosphate ceramics were produced by using a modified slip casting technique. Porosity in the cast and in the sintered ceramic was obtained through custom made PMMA beads similar to200-300 mum size. The green ceramic samples were prepared by suspending the apatite powder and PMMA beads in ...
MESOPOROUS SULPHATE DOPED HYDROXYAPATITE NANOPARTICLES FOR CONTROLLED RELEASE OF PROTEINS ALSHEMARY, AMMAR Z.; Muhammed, Yasser; SALMAN, NADER A.; Motameni, Ali; Gürbüz, Rıza (2022-1-01) All rights reserved.The purpose of this study is to synthesize and characterize the mesoporous nanostructure of Hydroxyapatite (HA), evaluate the impact of the addition of sulphate ions (SO42-) on the microstructure properties of HA, and assess the ability of the prepared materials to be used as a carrier for Bovine serum albumin (BSA) protein. This study successfully synthesized 0.07 mole of SO42- substituted HA using the reflux microwave-assisted wet precipitation method and fully characterized it using m...
Synthesis of calcium carbonate microspheres via inert gas bubbling for orthopedic applications Oral, Cagatay M.; Caliskan, Arda; Goctu, Yagmur; KAPUSUZ, DERYA; Ercan, Batur (Elsevier BV, 2020-02-15) Calcium carbonate (CaCO3) microspheres consisting of vaterite polymorph have been widely used in biomedical applications. Specifically, vaterite microspheres having hollow cores showed significant potential in drug delivery, however the spontaneous transformation of vaterite to other polymorphs in aqueous environments reduced its controlled in vivo release capability. In this work, calcite and aragonite microspheres having hollow/porous inner cores were synthesized -for the first time-using sodium dodecyl s...

Citation Formats

D. Bayraktar and A. Tas, “Biomimetic preparation of HA precursors at 37 degrees C in urea- and enzyme urease-containing synthetic body fluids,” 1999, vol. 599, p. 159, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/64716.