Dietary selenium- and vitamin E-induced alterations in some rabbit tissues

Date

1997-09-01

Author

Turan, B
Zaloglu, N
Koc, E
Saran, Y
Akkas, N

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

274
views

0
downloads

The present study was designed to investigate and compare the effects of dietary selenium (Se) and vitamin E on some physiological parameters and histological changes in liver, heart, and skin tissues, as well as the blood parameters and the related enzymes. Both sex young rabbits were fed with deficient (9.8 mu g/kg diet), adequate (225 mu g/kg diet), and rich (4.2 mg/kg diet) Se and vitamin E diets for 12-15 wk for this purpose As the plasma Se levels and the erythrocyte glutathione (GSH) peroxidase activity decreased (79.8 +/- 9.4 ng/mL and 2.0 +/- 0.3 U/g Hb, respectively) in the deficient group, these values increased (100.4 +/- 2.7 ng/mL and 14.5 +/- 4.3 U/g Hb) in the rich group significantly with respect to the control group. The other antioxidant enzyme activities and the related element levels did not change significantly in either one of the experimental groups. Although the platelet counts of the two experimental groups were not different from the control values, the collagen and the adenosine diphosphate (ADP) stimulated platelet aggregation rate and intensity increased in the deficient group (p < 0.05) and decreased very significantly (p < 0.001) in the rich group. In both of the experimental groups, as the percentage values of the neutrophils decreased, the lymphocytes and the eosinophils increased significantly. According to the light microscopic investigations, the observed lesions of considerable intensity within the tissues that elicit cell degenerations were more pronounced in the animals fed with the rich diet than in those fed with the deficient diet.

Subject Keywords

Inorganic Chemistry, Clinical Biochemistry, Biochemistry, Endocrinology, Diabetes and Metabolism, Biochemistry, medical, General Medicine

URI

https://hdl.handle.net/11511/68018

Journal

BIOLOGICAL TRACE ELEMENT RESEARCH

DOI

https://doi.org/10.1007/bf02917474

Collections

Department of Engineering Sciences, Article

Suggestions

OpenMETU
Core

Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischernic stroke Demirdogen, Birsen Can; Turkanoglu, Aysun; Bek, Semai; Sanisoglu, Yavuz; Demirkaya, Seref; Vural, Okay; Arinc, Emel; Adalı, Orhan (Elsevier BV, 2008-01-01) Objectives: In recent years, importance of enzyme activity measurements, in addition to genotyping, in epidemiological studies relating paraoxonase 1 (PON1) and vascular disease was emphasized. This is the first report evaluating paraoxonase and arylesterase activities as risk factors for ischemic stroke. In addition, PON1 192Gln(Q)/Arg(R) and 55Leu(L)/Met(M) polymorphisms were also analyzed.
Aromatic amino acid synthesis performance of bacillus acidocaldarius Kocabaş, Pınar; Çalık, Pınar; Department of Chemical Engineering (2004) In this study, the effects of bioprocess operation parameters on aromatic amino acid synthesis performance of Bacillus acidocaldarius were investigated. Firstly, in laboratory scale shake-bioreactors, a defined medium was designed in terms of its carbon and nitrogen sources, to achieve the highest cell concentration. Thereafter, the effects of bioprocess operation parameters, i.e., pH and temperature were investigated; and the optimum medium contained (kg m-3): fructose, 8; (NH4)2HPO4, 5; CaCl2, 0.2; KH2PO4...
Examination of the dielectrophoretic spectra of MCF7 breast cancer cells and leukocytes Çağlayan, Zeynep; Demircan Yalçın, Yağmur; Külah, Haluk (Wiley, 2020-03-01) The detection of circulating tumor cells (CTCs) in blood is crucial to assess metastatic progression and to guide therapy. Dielectrophoresis (DEP) is a powerful cell surface marker-free method that allows intrinsic dielectric properties of suspended cells to be exploited for CTC enrichment/isolation from blood. Design of a successful DEP-based CTC enrichment/isolation system requires that the DEP response of the targeted particles should accurately be known. This paper presents a DEP spectrum method to inve...
Effects of Formaldehyde Inhalation on Zinc, Copper and Iron Concentrations in Liver and Kidney of Male Rats ÖZEN, OĞUZ ASLAN; KUŞ, İLTER; Bakirdere, Sezgin; Sarsilmaz, Mustafa; YAMAN, MEHMET (Springer Science and Business Media LLC, 2011-05-01) In the present study, adult Wistar albino male rats were exposed to formaldehyde at different periods (subacute and subchronic) and concentrations (5.0 and 10.0 ppm) in order to figure out the changes in the concentration of Zn, Cu and Fe. It was observed that the formaldehyde inhalation caused gradual decline of body weights in the experimental groups when compared with control groups. It was found that subacute (4-week) or subchronic (13-week) exposure to formaldehyde for rats may cause growth retardation...
Vitamin E Derivative with Modified Side Chain Induced Apoptosis by Modulating the Cellular Lipids and Membrane Dynamics in MCF7 Cells Gok, Seher; Kuzmenko, Oleksandr; Babinskyi, Andrii; Severcan, Feride (Springer Science and Business Media LLC, 2021-01-01) The vitamin E derivative with side chain modification (TC6OAc) has been shown to possess anticancer activity in our earlier in vivo studies. It was hypothesized that, as Vitamin E (VE) and VE derivative are fat soluble lipophilic molecules, they exert their function by modulating the lipid metabolism and related pathways. This study aimed to evaluate the cellular impact of this VE derivative (2,5,7,8-Tetramethyl-2-(4 '-Methyl-3 '-Pentenyl)-6-Acetoxy Chromane-TC6OH), using alpha-tocopherol as a reference com...

Citation Formats

B. Turan, N. Zaloglu, E. Koc, Y. Saran, and N. Akkas, “Dietary selenium- and vitamin E-induced alterations in some rabbit tissues,” BIOLOGICAL TRACE ELEMENT RESEARCH, pp. 237–253, 1997, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/68018.