Synthesis of Selenium-Incorporated Alpha-Tricalcium Phosphate and Evaluation of Its Cement-Type Reactivity

Date

2018-12-01

Author

Baştuğ Azer, Bersu
Durucan, Caner

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Alpha-tricalcium phosphate (α-TCP) is a promising hard tissue analog due to its cement-type hydraulic conversion to the mineral component (calcium deficient hydroxyapatite, CDHAp) of natural bone tissue. A variety of different inorganic and organic agents can be incorporated to α-TCP in order to enhance its therapeutic and regenerative properties. In this study, an ionic incorporation - selenium (Se) - was accomplished to impart anti-carcinogenic property to α-TCP. Se-incorporated α-TCP (α-TCP:Se) was obtained by a solid-state reaction of custom synthesized Se-incorporated monetite (CaHPO4:Se) and calcium carbonate (CaCO3) precursors at 1200 °C for 2 h. The effect of Se-incorporation on crystal structure of α-TCP and on its’ cement type hydraulic reactivity at 37 °C was investigated in detail by crystallographic analysis (Rietveld refinement) and by isothermal calorimetry, respectively. At low amount of Se-incorporation (< 5 wt.%), α-TCP remains phase pure, however relatively higher amount of Se addition (10 wt.%) leads to formation of β-polymorph of TCP lacking the cement-type setting behavior. The SEM examinations showed that the morphological properties of α-TCP remain unaffected after doping with Se. However, Se-incorporation occurs at a limited extent, lower than the theoretically expected values as revealed by spectroscopical analyses. Se-incorporation does not change the reticulated needle/plate like morphology of the CDHAp, which is characteristic to cement-type hydration and hardening. Se-incorporated TCPs fully convert to CDHAp, but Se-incorporation changes the reaction kinetics and mechanistic path for α-TCP to CDHAp cement conversion and higher amount of Se addition slows down the reaction kinetics. The results imply that an optimal Se amount is critical the preserve intrinsic cement nature/behavior of α-TCP.

URI

https://hdl.handle.net/11511/75623

Conference Name

Materials Research Society Fall Meeting, (2 - 07 Aralık 2018)

Collections

Department of Metallurgical and Materials Engineering, Conference / Seminar

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Citation Formats

B. Baştuğ Azer and C. Durucan, “Synthesis of Selenium-Incorporated Alpha-Tricalcium Phosphate and Evaluation of Its Cement-Type Reactivity,” presented at the Materials Research Society Fall Meeting, (2 - 07 Aralık 2018), Massachusetts, United States Of America, 2018, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/75623.