Nanoparticle Based Delivery of miRNAs to Overcome Drug Resistance in Breast Cancer

Date

2016-01-01

Author

Yalçın Azarkan, Serap
Gündüz, Ufuk

Metadata

Show full item record

Item Usage Stats

81
views

0
downloads

URI

https://hdl.handle.net/11511/79683

Journal

Journal ofJNanomedicine & Nanotechnology

Collections

Unverified, Article

Suggestions

OpenMETU
Core

Nanoparticle-based drug delivery in cancer: the role of cell membrane structures Yalcin, Serap; Ozluer, Ozlem; Gündüz, Ufuk (2016-11-01) Development of novel drug-delivery systems aims to specifically deliver anticancer drugs to tumor tissues and improve the efficiency of chemotherapy, while minimizing side effects of drugs on healthy tissues and organs. However, drug-delivery systems are confronted by membrane barriers and multiple drug resistance in cancer cells. In recent years, the obtained results indicate an important role of lipids, proteins and carbohydrates in apoptosis, drug transport and the process of cellular uptake of nanoparti...
Nanoparticles Based Drug Delivery Systems to Overcome Multidrug Resistance in Cancer The Role of Membrane Lipids Proteins and Carbohydrates Özlüer, Özlem; Yalçın Azarkan, Serap; Gündüz, Ufuk (null; 2016-09-28) Multidrug resistance (MDR) is a major problem in success of cancer chemotherapy on tumor cell growth, limits the prolonged and effective use of chemotherapy. The use of nanomaterial based drug carriers in cancer treatment offers exciting opportunities to enhance delivery of therapeutics to the tumor site (1). This is also known as targeted drug delivery providing differential distribution of drugs to the tumor site while significantly reducing the overall toxicity. Here, we critically discuss the role of th...
Nanocrystal Encoded FluorescentMicrobeads for Proteomics AntibodyProfiling and Diagnostics ofAutoimmune Diseases Sukhanova, Alyona; Susha , Andrei; Bek, Alpan; Mayilo, Sergiy; Rogach , Andrey; Feldmann, Jochen; Oleinikov, Vladimir; Reveil, Brigitte; Donvito, Beatrice; Cohen, Jacques; Nabiev, İgor (2007-01-01) The first application of nanocrystal (NC)-encoded microbeads to clinical proteomics is demonstrated by multiplexed detection of circulating autoantibodies, markers of systemic sclerosis. Two-color complexes, consisting of NC-encoded, antigen-covered beads, anti-antigen antibody or clinical serum samples, and dye-tagged detecting antibodies, were observed using flow cytometry assays and on the surface of single beads. The results of flow cytometry assays correlated with the ELISA technique and provided clear...
Nanoparticles Based on Plasma Proteins for Drug Delivery Applications Tezcaner, Ayşen; Keskin, Dilek (2016-01-01) Background: Nanoparticulate delivery systems receive a lot of attention in pharmaceutical research and market due to their in vivo stability, ability to protect entrapped drug, and ease of cellular penetration. The hemo-compatibility and the clearance half-life are important parameters of the nanodelivery systems that will be administered through intravenous route. Natural components, like blood plasma proteins are ideal sources of biomaterial for such systems with their long in vivo half-lives. Methods: Th...
Nanopatterning of Collagen Scaffolds Improve the Mechanical Properties of Tissue Engineered Vascular Grafts Zorlutuna, P.; Elsheikh, A.; Hasırcı, Vasıf Nejat (2009-04-01) Tissue engineered constructs with cells growing in an organized manner have been shown to have improved mechanical properties. This can be especially important when constructing tissues that need to perform under load, such as cardiac and vascular tissue. Enhancement of mechanical properties of tissue engineered vascular grafts via orientation of smooth muscle cells by the help of topographical cues have not been reported yet. In the present study, collagen scaffolds with 650, 500, and 332.5 nm wide nanocha...

Citation Formats

S. Yalçın Azarkan and U. Gündüz, “Nanoparticle Based Delivery of miRNAs to Overcome Drug Resistance in Breast Cancer,” Journal ofJNanomedicine & Nanotechnology, pp. 0–0, 2016, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/79683.