Preparation of a Nanobiocomposite Scaffold Containig Boron Modified Bioactive Glass Nanoparticles and Biopolymers of Cellulose acetate Pullulan Gelatin and Evaluation of its Application in Dentin Tissue Engineering

2016-08-24
Rad Moonesi, Reza
Keskin, Dilek
Evis, Zafer
Erdoğan, Enes
Şahin, Sıla
Tezcaner, Ayşen
Show full item record
148
views
0
downloads
Every year a large number of dental restorations are carried out in the world and most of them do not succeed. Dentin layer has a mineral structure and it is the most damaged part in tooth caries. A regenerative approach for repairing of the damaged dentin-pulp complex or generating a new tissue is needed. We synthesized boron modified bioglass nanoparticles and developed a three-dimensional boron modified bioglass nanoparticles/cellulose acetate/pullulan/gelatin (b-BGNPs/ CA/PULL/GEL) based scaffold to investigate its application potential for dentin regeneration. The composition of obtained b-BGNPs was almost consistent with the designed composition. FTIR analysis revealed that synthesized bioglass, possessed the characteristic functional groups related to the compositions before and after boron modification. Scaffolds containing aligned and tubular structures with diameter of 11.6 μm were obtained by thermally induced phase separation (TIPS) and porogen leaching methods. Human Dental Pulp Stem Cells (hDPSCs) were isolated from human third molars by the enzymatic digestion method. In vitro degradation analysis, porosity measurements, mechanical tests, in vitro biomineralization studies and also cell culture studies are under investigation.
https://hdl.handle.net/11511/84664
International Conference on Polymer Science and Engineering (22 - 24 Ağustos 2016)
Department of Engineering Sciences, Conference / Seminar

Suggestions

Preparation of a nanobiocomposite scaffold containing boron modified bioactive glass nanoparticles and biopolymers of cellulose acetate pullulan gelatin and evaluation of its application in dentin tissue engineering
Moonesi Rad, Reza; Keskin, Dilek; Evis, Zafer; Erdogan, Enes; Şahin, Sıla; Tezcaner, Ayşen (null; 2016-09-13)
Every year a large number of dental restorations are carried out in the world and most of them do not succeed. Dentin layer has a mineral structure and it is the most damaged part in tooth caries. A regenerative approach for repairing of the damaged dentin-pulp complex or generating a new tissue is needed. We synthesized boron modified bioglass nanoparticles and developed a three-dimensional boron modified bioglass nanoparticles/cellulose acetate/pullulan/gelatin (b-BGNPs/ CA/PULL/GEL) based scaffold to inv...
In vitro performance of a nanobiocomposite scaffold containing boron-modified bioactive glass nanoparticles for dentin regeneration
Rad, Reza Moonesi; Pazarçeviren, Ahmet Engin; Akguen, Elif Ece; Evis, Zafer; Keskin, Dilek; Sahin, Sila; Tezcaner, Ayşen (SAGE Publications, 2019-01-01)
Every year, many dental restoration methods are carried out in the world and most of them do not succeed. High cost of these restorations and rejection possibility of the implants are main drawbacks. For this reason, a regenerative approach for repairing the damaged dentin-pulp complex or generating a new tissue is needed. In this study, the potential of three-dimensional cellulose acetate/oxidized pullulan/gelatin-based dentin-like constructs containing 10 or 20% bioactive glass nanoparticles was studied t...
Preparation and characterization of hydroxyapatite containing acrylic bone cements
Başgörenay, Burcu; Hasırcı, Nesrin; Department of Polymer Science and Technology (2004)
Acrylic bone cements are one of the most important biomaterials used in orthopaedic surgery and dental applications to fill the cavities or provide mechanical interlock between prosthesis and the bone. Their biocompatibility can be increased by addition of different materials into the formulation, such as hydroxyapatite. Besides all the advantages, bone cements have several drawbacks including tissue necrosis, chemical necrosis, shrinkage of the cement and aseptic loosening. Therefore painstaking research a...
Effects of hydrogen peroxide bleaching on human dentin and enamel microstructure and function
Gökduman, Kurtuluş; Severcan, Feride; Department of Biotechnology (2005)
In recent years bleaching of vital teeth has become popular among both dentist and patients. Different bleaching agents were used for this purpose. They are either applied professionally at high dose (office bleaching) or by patient at lower dose (home bleaching). In the present work we studied the effects of a high concentration bleaching agent (35% hydrogen peroxide), and a low concentration bleaching agent (17% carbamide peroxide) on human enamel and dentin using Fourier Transform Infrared (FTIR) Spectro...
Preparation and Characterization of Chitosan Containing Acrylic Bone Cement Formulations
Endogan, Tugba; Kızıltay, Aysel; Hasırcı, Nesrin (2009-05-22)
Bone cements are used in orthopaedic surgery and dentistry, and the commonly used commercial ones are prepared from poly (methylmethacrylate) (PMMA). In orthopaedic surgery bone cements are used as filling agents for the treatment of damaged tissues and they are used to stabilize the prosthesis by providing the mechanical interlock between bone and metal during the use of metal prothesis and to provide the homogeneous distribution of applied load. In this study, bone cements compositions were prepared by us...
Citation Formats
R. Rad Moonesi, D. Keskin, Z. Evis, E. Erdoğan, S. Şahin, and A. Tezcaner, “Preparation of a Nanobiocomposite Scaffold Containig Boron Modified Bioactive Glass Nanoparticles and Biopolymers of Cellulose acetate Pullulan Gelatin and Evaluation of its Application in Dentin Tissue Engineering,” presented at the International Conference on Polymer Science and Engineering (22 - 24 Ağustos 2016), New Orleans, USA, 2016, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/84664.
METU IIS - Integrated Information Service open@metu.edu.tr