WLS Expression in ER+ Breast Cancers

Wnt signaling is a developmentally important signaling pathway and is mutated and/or deregulated in various cancer types. We identified a retromer protein SNX3 that regulates recycling of WLS (Wntless) receptor that has a role in WNT ligand secretion. Secreted WNT ligands can then bind to Frizzled family receptors on that same cell or neighboring cells to activate the nuclear accumulation of β-catenin in the nucleus. We identified SNX3 in a transcriptomic screen where shorter 3’UTR isoforms were over represented in breast cancers. Given that SNX3 has been implicated in endocytic recycling of WLS, we hypothesized SNX3 to be a potential cancer related gene in breast cancers through regulating WLS. Therefore, here, we aimed to study SNX3 in ER+ breast cancers that are known not to be heavily dependent on Wnt signaling. We present evidence on SNX3 silencing in ER+ breast cancers and how WLS and Wnt signaling cascades are affected. Further studies will clarify the significance of SNX3/WLS connection and Wnt signaling in ER+ breast cancers
International Congress of the Molecular Biology Association of TurkeyAssociation of Turkey, (5 - 08 Eylül 2018)


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Citation Formats
A. E. Erson Bensan and A. Çırçır Hatıl, “WLS Expression in ER+ Breast Cancers,” presented at the International Congress of the Molecular Biology Association of TurkeyAssociation of Turkey, (5 - 08 Eylül 2018), İzmir, Türkiye, 2018, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/85301.