Enhancing biocompatibility of tantalum via anodization for orthopedic applications

Date

2018-12-06

Author

Uslu, Ece
Ercan, Batur

Metadata

Show full item record

Item Usage Stats

143
views

0
downloads

Tantalum and its alloys have been investigated as the next generation of orthopedic implant materials in the last decade. Being a valve metal, tantalum forms a naturally occurring stable oxide layer approximately 3-5 nm on its surface at ambient conditions and this layer both prevents heavy ion release from the metal and provides a natural barrier for implant corrosion. In fact, due to its chemically inert nature, tantalum has the highest corrosion resistance of all metals used in orthopedic applications. Tantalum also exhibits higher fatigue properties compared to the currently-used implant materials. Despite having ideal properties for orthopedic applications, bioinert nature of tantalum surfaces, which limits osseointegration with the juxtaposed tissue, is the leading problem to be addressed before its widespread use in implants. To overcome this problem, surface modification of tantalum within nanoscale could be a potential remedy to enhance its bioactivity. Anodization is an electrochemical process which produces oxide based nanofeatured surfaces on various metals. It gained popularity in the last decade due to its versatility in controlling biomaterial surface topography. In literature, it was shown that anodized nanostructured surfaces having different morphologies, topographies and feature sizes enhanced bone cell adhesion, proliferation and cellular functions in orthopedic applications. Specifically, anodized titanium and its alloys were well characterized to enhance cellular functions in vitro. However, there is very limited data on the anodization of tantalum for orthopedic applications. In this study, tantalum samples were anodized using 1M H2SO4+ 3.3 wt % NH4F, 1:9 (v/v) concentrated and aqueous HF/H2SO4 solutions to obtain oxide based nanofeatures on its surface. Upon anodization, 4 different surface morphologies, namely nanodimple, nanotubular, nanoporous and nanocoral, were successfully obtained on tantalum surfaces. Furthermore, anodization duration (1min-4hr) and voltages (10-80V) were fine-tuned to control feature sizes between 25 to 140 nm for the nanodimple, nanocoral and nanoporous morphologies. Topographical investigations indicated higher nanophase surface roughness on anodized surfaces compared to as-received tantalum. Anodized samples also expressed enhanced surface hydrophilicity independent of the morphology and feature size. To investigate biocompatibility of the samples, osteoblast (ATCC CRL-11372) adhesion and proliferation were examined up to 7 days of culture. Results indicated enhanced cellular functions on nanodimple, nanocoral and nanoporous morphologies compared to non-anodized surfaces. Furthermore, immersing these samples into simulated body fluid up to 1 month showed enhanced bioactivity of these surfaces compared to nonanodized tantalum. In conclusion, surface modification of tantalum via anodization could be a potential way to enhance biocompatibility of tantalum for orthopedic applications

URI

https://hdl.handle.net/11511/88039
https://www.mrs.org/fall-2018-symposium-sessions
https://www.mrs.org/docs/default-source/meetings-events/fall-meetings/2018/abstract-book.pdf?sfvrsn=421abc10_14

Conference Name

MRS Fall Meeting and Exhibit, November 25-30 2018

Collections

Department of Metallurgical and Materials Engineering, Conference / Seminar

Suggestions

OpenMETU
Core

Enhanced Sintering of TiNi Shape Memory Foams under Mg Vapor Atmosphere Aydoğmuş, Tarık; Bor, Sakir (2012-12-01) TiNi alloy foams are promising candidates for biomaterials to be used as artificial orthopedic implant materials for bone replacement applications in biomedical sector. However, certain problems exist in their processing routes, such as formation of unwanted secondary intermetallic phases leading to brittleness and deterioration of shape memory and superelasticity characteristics; and the contamination during processing resulting in oxides and carbonitrides which affect mechanical properties negatively. Mor...
Comprehensive Evaluation of the Biological Properties of Surface-Modified Titanium Alloy Implants Piszczek, Piotr; Radtke, Aleksandra; Ehlert, Michalina; Jedrzejewski, Tomasz; Sznarkowska, Alicja; Sadowska, Beata; Bartmanski, Michal; Erdoğan, Yaşar Kemal; Ercan, Batur; Jedrzejczyk, Waldemar (2020-02-01) An increasing interest in the fabrication of implants made of titanium and its alloys results from their capacity to be integrated into the bone system. This integration is facilitated by different modifications of the implant surface. Here, we assessed the bioactivity of amorphous titania nanoporous and nanotubular coatings (TNTs), produced by electrochemical oxidation of Ti6Al4V orthopedic implants' surface. The chemical composition and microstructure of TNT layers was analyzed by X-ray photoelectron spec...
Enhanced bioactivity and low temperature degradation resistance of yttria stabilized zirconia/clay composites for dental applications Tufan, Yiğithan; Park, Jongee; Öztürk, Abdullah; Ercan, Batur (2022-12-01) © 2022 Elsevier LtdYttria stabilized zirconia (YSZ)/clay composites were produced to improve osseointegration and undesired tetragonal-to-monoclinic phase transformation (low temperature degradation, LTD) of YSZ ceramics so that long-term clinical success of YSZ implants is achieved. Various amounts (0.5,1,2, and 4 wt%) of clay was incorporated to YSZ. Predetermined amounts of clay and YSZ were mixed and pressed uniaxially at 15 MPa into compacts that were subsequently pressureless sintered at 1450 °C. Dens...
Development of microcarrier systems for bone tissue engineering Aydoğdu, Hazal; Tezcaner, Ayşen; Baran, Erkan Türker; Department of Biomedical Engineering (2015) Current strategies in bone tissue engineering have largely focused on development of carrier systems for repair and regeneration of bone tissue defects. The microcarrier systems offer an efficient method of delivery of cells with non-invasive injectable system. In this study, three-dimensional hydrogel microspheres were developed via water-in-oil emulsion method. In the first part of the thesis, porous pullulan (PULL) microspheres, with average size of 153±46 µm, were prepared and the surface of the microsp...
In vitro and in vivo properties of graphene-incorporated scaffolds for bone defect repair Jodati, Hossein; Yilmaz, Bengi; Evis, Zafer (2021-01-01) The employment of graphene and its derivatives, graphene oxide and reduced graphene oxide, is extending from bioimaging and fabrications of biosensors to drug delivery and tissue engineering in the biomedical area. Graphene family-incorporated scaffolds, used in bone tissue engineering and bone regenerative medicine, profit superior properties of these materials, such as enhanced mechanical properties, large surface area, and the existence of functional groups. At the same time, problems related to cytotoxi...

Citation Formats

E. Uslu and B. Ercan, “Enhancing biocompatibility of tantalum via anodization for orthopedic applications,” presented at the MRS Fall Meeting and Exhibit, November 25-30 2018, Boston, Massachusetts, USA, 2018, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/88039.