Amino Acid And Peptide Based Gels

Download

Thesis_Güzide_Aykent_düzeltilmiş_son.pdf

Date

2021-2-12

Author

Aykent, Güzide

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

399
views

156
downloads

Self-assembling peptides and amino acid derivatives are becoming an emerging field especially in last decades. Especially for their usage in biomedical applications, tissue engineering and drug delivery, extensive research are being done. Large variety of peptides with different physical and chemical properties were acquired by using different amino acids and their sequences. As a more easily synthesized and bio-inspired alternative materials to the compounds used nowadays for organic electronic devices, gel forming peptides are getting more attention. Design, synthesis and applications of these peptides in biomedical materials and organic electronic devices is a challenging topic that requires alternative structures to get better and easily applied systems. Not only self-assembling peptides, also low molecular weight gelators of amino acid derivatives were developed quite for a wide range of applications. In the first part of this study, conductive peptide-based gels were developed through chemical peptide synthesis, utilizing artificial amino acids. To enhance the conductivity of self-assembling peptides, different artificial amino acids were developed that provide well-ordered structures with enhanced charge mobility through π-π stacking of aromatic units. By using these artificial amino acids different peptide sequences that are able to self-assemble were synthesized and new conductive bio-inspired materials were developed with higher conductivity values than the literature data. In the second part of this study, amino acid based low molecular weight gelators were discovered, even some of them have the lower molecular weight among other amino acid based gelators found in the literature. These newly developed materials are able to form gel in a wide range of solvents and thus, utilized for different applications such as dye removal and drug release studies.

Subject Keywords

peptide, amino acid, self-assembly, conductive gel, drug release

URI

https://hdl.handle.net/11511/89798

Collections

Graduate School of Natural and Applied Sciences, Thesis

Suggestions

OpenMETU
Core

Dimethyl ether, diethyl ether & ethylene from alcohols over tungstophosphoric acid based mesoporous catalysts Ciftci, Aysegul; VARIŞLI, DİLEK; Tokay, Kenan Cem; Sezgi, Naime Aslı; Doğu, Timur (2012-10-01) Tungstophosphoric acid (TPA) incorporated silicate structured new mesoporous catalysts were synthesized following one-pot hydrothermal and impregnation procedures. Surface area of TPA@MCM-41, which was prepared by impregnating TPA into MCM-41, was two orders of magnitude higher than the surface area of pure TPA and this catalyst showed very high activity in dehydration reactions of both ethanol and methanol. Ethanol fractional conversion values reaching to 1.0 was obtained at 300 degrees C at a space time o...
Biodegradable nanomats produced by electrospinning: Expanding multifunctionality and potential for tissue engineering Ashammakhi, N.; Ndreu, A.; Piras, A. M.; Nikkola, L.; Sindelar, T.; Ylikauppila, H.; Harlin, A.; Gomes, M. E.; Neves, N. M.; Chiellini, E.; Chiellini, F.; Hasırcı, Vasıf Nejat; Redl, H.; Reis, R. L. (2007-03-01) With increasing interest in nanotechnology, development of nanofibers (n-fibers) by using the technique of electrospinning is gaining new momentum. Among important potential applications of n-fiber-based structures, scaffolds for tissue-engineering represent an advancing front. Nanoscaffolds (n-scaffolds) are closer to natural extracellular matrix (ECM) and its nanoscale fibrous structure. Although the technique of electrospinning is relatively old, various improvements have been made in the last decades to...
Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways. KHURANA, V; et. al. (2017-02-22) Numerous genes and molecular pathways are implicated in neurodegenerative proteinopathies, but their inter-relationships are poorly understood. We systematically mapped molecular pathways underlying the toxicity of alpha-synuclein (alpha-syn), a protein central to Parkinson's disease. Genome-wide screens in yeast identified 332 genes that impact alpha-syn toxicity. To "humanize'' this molecular network, we developed a computational method, Transpose Net. This integrates a Steiner prize-collecting approach w...
Nanomolar Selective G Quadruplex Ligands from One Pot Thermodynamic and Structural Studies of Azacyanines Engelhart, Aaron; Persil Çetinkol, Özgül; Nanjunda, Rupesh; Wılson, Davıd; Hud, Nıcholas (null; 2008-11-15) The observation that G-quadruplex structures exist in nucleic acid sequences associated with cancers has generated substantial interest in G quadruplexes as potential antineoplastics. The G quadruplex, with planar G tetrads, is an appealing nucleic acid drug target, as the G tetrad is structurally distinct from the Watson-Crick base pair. High-affinity G-quadruplex ligands have begun to show medicinal promise, although the connection between G-quadruplex binding and in vivo activity might not always be obvi...
Aptamer-enabled uptake of small molecule ligands Auwardt, Supipi Liyamali; Seo, Yeon-Jung; İlgü, Müslüm; Ray, Judhajeet; Feldges, Robert R.; Shubham, Shambhavi; Bendickson, Lee; Levine, Howard A.; Nilsen-Hamilton, Marit (Springer Science and Business Media LLC, 2018-10-24) The relative ease of isolating aptamers with high specificity for target molecules suggests that molecular recognition may be common in the folds of natural RNAs. We show here that, when expressed in cells, aptamers can increase the intracellular concentrations of their small molecule ligands. We have named these aptamers as DRAGINs (Drug Binding Aptamers for Growing Intracellular Numbers). The DRAGIN property, assessed here by the ability to enhance the toxicity of their ligands, was found for some, but no...

Citation Formats

G. Aykent, “Amino Acid And Peptide Based Gels,” Ph.D. - Doctoral Program, Middle East Technical University, 2021.