A new method for hydroxychloroquine detection

Download
2022-2-09
Ünal Taş, Dilek
Silver nanoparticles (AgNPs) possess unique physicochemical and optical properties. Their localized surface plasmon resonance (LSPR) signal depends on size, shape and composition of the nanoparticles and may change with the intermolecular interactions providing opportunity to design distinct detection platforms for ions, metabolites or drugs. Here, a facile, cost-effective, rapid colorimetric method based on the citrate capped AgNPs (Cit-AgNPs) was developed for hydroxychloroquine (HCQ) detection in aqueous samples. HCQ is an antimalarial drug that has been used for the treatment of diseases such as malaria, rheumatoid arthritis and lupus. It was also extensively used during the initial phase of COVID-19 pandemic. As any other pharmaceutical, high manufacturing levels of HCQ and its uncontrolled use pose possible environmental problems and could become a public health concern due to its accumulation in water systems in the long run. Consequently, the development of fast, straightforward and sensitive sensors for HCQ in aqueous solutions is still in need. The developed platform within the context of this thesis was selective to HCQ among other drugs and quinoline derivatives under the optimized conditions (30.0 mM NaCl, room temperature, 5 minutes of incubation). Limit of detection (LOD) and linear dynamic range (LDR) of the developed platform were found as 9.2 nM and 18.0-240.0 nM, respectively. The applicability of the sensor was tested on HCQ spiked human urine samples (containing 50.0, 120.0 and 240.0 nM HCQ) since HCQ was mainly eliminated through renal clearance. The recovery range, determined to be as 86-98%, supporting the use of the developed platform for HCQ detection as a simple, rapid, and reliable tool.

Suggestions

A Solution to the Adhesion Problem of Oxide Thin Films on Zinc Selenide Optical Substrates
Cosar, M. B.; Aydogdu, G. H.; Batman, H.; Ozhan, A. E. S. (2016-05-13)
Zinc selenide optical substrates have high transparency within the 0.5- to 14.0-mu m wavelength range. This makes them an attractive candidate for multiband imaging applications in optical components. In order to minimize reflection loss in visible, near-infrared, and mid-infrared applications, zinc selenide lenses are coated with multi-layered oxide thin films by physical vapor deposition method or ion beam deposition. In this study, a four-layer anti-reflective filter at 1.064 gm and between 3.6 and 4.9 g...
Highly selective Hg2+ colorimetric sensor using green synthesized and unmodified silver nanoparticles
Farhadi, Khalil; Forough, Mehrdad; Molaei, Rahim; Hajizadeh, Salahaddin; Rafipour, Aysan (2012-01-01)
The reaction between biologically green synthesized silver nanoparticles (Ag NPs) and mercury (II) ions was introduced as a new and high potential calorimetric sensor for the selective recognition and monitoring of mercuric ions in aqueous samples. The green synthesized silver nanoparticles were characterized with surface plasmon resonance (SPR) ultraviolet spectroscopy (UV-vis), SEM and X-ray diffraction analysis (XRD) techniques. The fresh biologically synthesized silver nanoparticles are yellowish-brown ...
Effective mass and peculiarity of optical properties of Cadmium Sulfide nanoparticles
Muradov, M. B.; Eyvazova, G. M.; Turan, Raşit; Maharramov, A. M. (2008-12-01)
X-ray diffraction data, electron microscope and optical properties of cadmium sulfide nanoparticles were analyzed. It is shown that the value of the reduced effective mass of charge carriers in nanoparticles differs from bulk crystals. Changes of effective mass and "red shift" in values of band gap are explained by the occurrence of additional electronic potential in nanoparticles.
The Effect of Ultrasonication on the Size and Morphology of Iron Oxide - Chitosan Nano and Microparticles
Akin, Deniz; YAKAR, ARZU; Gündüz, Ufuk (2013-04-28)
The aim of this study is to synthesize magnetic Fe3O4-chitosan nano and microparticles (Fe3O4-CPs) by suspension cross-linking and ionic gelation methods and investigate the effect of ultrasonication on the size, morphology and magnetic properties. The synthesized particles were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and vibrating sample magnetometry (VSM). The results showed that the ultrasonication decreased the mean particle diameter and enhanced magnetic ...
Structural vibration analysis of single walled carbon nanotubes with atom-vacancies
Doğan, İbrahim Onur; Yazıcıoğlu, Yiğit; Department of Mechanical Engineering (2010)
Recent investigations in nanotechnology show that carbon nanotubes (CNT) have one of the most significant mechanical, electrical and optical properties. Interactions between those areas like electrical, optical and mechanical properties are also very promising in both research and industrial fields. Those unique characteristics are built by mainly the atomistic structure of the carbon nanotubes. In this thesis, the effects of vacant atoms on single walled carbon nanotubes (SWCNT) are investigated using matr...
Citation Formats
D. Ünal Taş, “A new method for hydroxychloroquine detection,” M.S. - Master of Science, Middle East Technical University, 2022.