A new method for hydroxychloroquine detection

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2022-2-09
Ünal Taş, Dilek
Silver nanoparticles (AgNPs) possess unique physicochemical and optical properties. Their localized surface plasmon resonance (LSPR) signal depends on size, shape and composition of the nanoparticles and may change with the intermolecular interactions providing opportunity to design distinct detection platforms for ions, metabolites or drugs. Here, a facile, cost-effective, rapid colorimetric method based on the citrate capped AgNPs (Cit-AgNPs) was developed for hydroxychloroquine (HCQ) detection in aqueous samples. HCQ is an antimalarial drug that has been used for the treatment of diseases such as malaria, rheumatoid arthritis and lupus. It was also extensively used during the initial phase of COVID-19 pandemic. As any other pharmaceutical, high manufacturing levels of HCQ and its uncontrolled use pose possible environmental problems and could become a public health concern due to its accumulation in water systems in the long run. Consequently, the development of fast, straightforward and sensitive sensors for HCQ in aqueous solutions is still in need. The developed platform within the context of this thesis was selective to HCQ among other drugs and quinoline derivatives under the optimized conditions (30.0 mM NaCl, room temperature, 5 minutes of incubation). Limit of detection (LOD) and linear dynamic range (LDR) of the developed platform were found as 9.2 nM and 18.0-240.0 nM, respectively. The applicability of the sensor was tested on HCQ spiked human urine samples (containing 50.0, 120.0 and 240.0 nM HCQ) since HCQ was mainly eliminated through renal clearance. The recovery range, determined to be as 86-98%, supporting the use of the developed platform for HCQ detection as a simple, rapid, and reliable tool.

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Citation Formats
D. Ünal Taş, “A new method for hydroxychloroquine detection,” M.S. - Master of Science, Middle East Technical University, 2022.