Effects of the doping concentration of boron on physicochemical, mechanical, and biological properties of hydroxyapatite

2022-01-01
Jodati, Hossein
Tezcaner, Ayşen
Alshemary, Ammar Z.
Şahin, Volkan
Evis, Zafer
© 2022 Elsevier Ltd and Techna Group S.r.l.Ion doping is an approach to modify properties of materials, like hydroxyapatite (HA), that contributes to designing biomaterials with desired characteristics applicable in bone defect treatments. Recently, boron (B) has been noticed in biomaterial fields due to its beneficial effects on formation, growth, and quality of bone. In this study, B-doped HA nanoparticles with different molar concentrations of B (0.05, 0.1, 0.25, and 0.5) were synthesized through microwave-assisted wet precipitation. The effects of B content on various properties of HA were evaluated. The results demonstrated that the size of HA particles reduced from 106 nm to 89-85 nm in B doped materials. Meanwhile, the crystallinity degree of B doped HA (BHA) samples was between 89.90% and 93.77%, compared to 95.19% of HA. Diametral tensile strength of samples was measured in the ranges of 2.51 and 3.61 with no significant difference among groups. The micro-hardness of HA was 0.88 GPa, whilst doped ones had hardness values of 0.5 GPa–0.68 GPa. Biodegradability of samples increased from less than 1% to approximately 4% after 28 days, while B-doping did not make any change in the degradation rate. Doping dosages were appropriate in terms of bioactivity and cell viability, and B doping caused higher bioactivity and cell proliferation. All changed properties were dose-dependent and more effective in doped groups with a higher amount of B. Despite proliferative effect, 260 μg/l and 770 μg/l of B release in two groups with the highest dopant concentrations did not positively influence the osteogenic activity of cells. Our results demonstrated that doping concentrations that resulted in B release ≤260 μg/l seem more appropriate dosage, especially for bone tissue engineering and substitute applications due to promoted bioactivity and proliferation, as well as no obstructive effects on mechanical properties and osteogenic activities of HA.
Ceramics International

Suggestions

Effects of biomimetic synthesis route and sintering temperature on physicochemical, microstructural, and mechanical properties of hydroxyapatite
Kaya, Yasemin; Jodati, Hossein; Evis, Zafer (2021-01-01)
Biomimetic synthesis of bioceramics using simulated body fluid (SBF) is a route to produce biomaterials with a more suitable microstructure and characteristics required for bone defect treatments. As matter of fact, the biomimetic method allows us to imitate the natural environment needed for the synthesis of bone-like materials, such as hydroxyapatite (HA). In this study, biomimetic HA was successfully synthesized through the microwave-assisted method by the employment of SBF in different ratios with water...
Interaction of anodized Ti6A17Nb with simulated body fluid
Izmir, Merve; Tufan, Yiğithan; Ercan, Batur (Journal of the Faculty of Engineering and Architecture of Gazi University, 2019-01-01)
The present work investigates modification of Ti6Al7Nb alloy surfaces using anodization for orthopedic applications. By optimizing the anodization parameters. nanotubular oxide layers with tubular diameters tailored between 25 nm to 140 nm was fabricated on Ti6Al7Nb alloy surfaces. When Ti6Al7Nb samples possessing nanotubular surface features were immersed in simulated body fluid for 30 days. calcium phosphate mineral formation was observed on these surfaces. Results showed that anodized Ti6Al7Nb samples wi...
Preparation and characterization of poly(epsilon-caprolactone) scaffolds modified with cell-loaded fibrin gel
Malikmammadov, Elbay; Endoğan Tanır, Tuğba; Kızıltay, Aysel; Hasırcı, Nesrin (2019-03-15)
Poly(epsilon-caprolactone) (PCL) is one of the most commonly used polymers in the production of tissue engineered scaffolds for hard tissue treatments. Incorporation of cells into these scaffolds significantly enhances the healing rate of the tissue. In this study, PCL scaffolds were prepared by wet spinning technique and modified by addition of fibrinogen in order to form a fibrin network between the PCL fibers. By this way, scaffolds would have micro and nanofibers in their structures. Drying of the wet s...
Modification of Acrylic Bone Cements with Oxygen Plasma and Additives
Endoğan Tanır, Tuğba; Kızıltay, Aysel; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2012-09-01)
Acrylic bone cements which are commonly used for the fixation of orthopedic prostheses, were prepared at different formulations, by using either ground poly(methyl methacrylate) (PMMA) particles or homogeneously synthesized PMMA microspheres with application of plasma and addition of various ingredients in order to improve mechanical and thermal properties. PMMA powders having three different particle size (ground and sieved particles with 0-50 mu m (BC1 group, average particle size: 21 mu m) and 50-150 mu ...
Influence of nanopatterns on endothelial cell adhesion: Enhanced cell retention under shear stress
Zorlutuna, P.; Rong, Z.; Vadgama, P.; Hasırcı, Vasıf Nejat (2009-09-01)
In this study, nanopatterned crosslinked films of collagen Type I were seeded with human microvascular endothelial cells and tested for their suitability for vascular tissue engineering. Since the films will be rolled into tubes with concentric layers of collagen, nutrient transfer through the collagen films is quite crucial. Molecular diffusivity through the collagen films, cell viability, cell proliferation and cell retention following shear stress were studied. Cells were seeded onto linearly nanogrooved...
Citation Formats
H. Jodati, A. Tezcaner, A. Z. Alshemary, V. Şahin, and Z. Evis, “Effects of the doping concentration of boron on physicochemical, mechanical, and biological properties of hydroxyapatite,” Ceramics International, pp. 0–0, 2022, Accessed: 00, 2022. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85129807410&origin=inward.