Superior Photodynamic Therapy of Colon Cancer Cells by Selenophene-BODIPY-Loaded Superparamagnetic Iron Oxide Nanoparticles

Date

2022-01-01

Author

Ozvural Sertcelik, Kubra Nur
Karaman, Osman
Almammadov, Toghrul
Günbaş, Emrullah Görkem
Kolemen, Safacan
Yagci Acar, Havva
Onbasli, Kubra

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

172
views

0
downloads

© 2022 Wiley-VCH GmbH.Development of targeted nanoparticles as carriers to deliver photosensitizers to cancer cells is highly beneficial for ensuring the expected therapeutic outcome of photodynamic therapy. Herein, polyacrylic acid (PAA) coated superparamagnetic iron oxide nanoparticles (SPIONs), conjugated with endothelial growth factor receptor (EGFR) targeting Cetuximab (Cet) were loaded with a BODIPY-based (BOD-Se-I) photosensitizer (Cet-PAA@SPION/BOD-Se-I) to achieve enhanced and selective photodynamic therapy on colon cancer cells. In vitro studies showed that Cet-PAA@SPION/BOD-Se-I improved phototoxicity dramatically compared to free BOD-Se-I on the HT29 cell line due to high uptake of the photosensitizer via endothelial growth factor receptor. Most importantly, the developed nano-agent completely eliminated the phototoxicity of BOD-Se-I on the healthy L929 cell line.

Subject Keywords

BODIPY, colon cancer, iron oxide nanoparticles, photodynamic therapy, photosensitizers, superparamagnetism, PHOTOSENSITIZERS, BODIPY, colon cancer, iron oxide nanoparticles, photodynamic therapy, photosensitizers, superparamagnetism

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85135249624&origin=inward
https://hdl.handle.net/11511/99341

Journal

ChemPhotoChem

DOI

https://doi.org/10.1002/cptc.202200104

Collections

Department of Chemistry, Article

Suggestions

OpenMETU
Core

CpG oligodeoxynucleotide- loaded PAMAM dendrimer-coated magnetic nanoparticles promote apoptosis in breast cancer cells Pourianazar, Negar Taghavi; Gündüz, Ufuk (2016-03-01) One major application of nanotechnology in cancer treatment involves designing nanoparticles to deliver drugs, oligonucleotides, and genes to cancer cells. Nanoparticles should be engineered so that they could target and destroy tumor cells with minimal damage to healthy tissues. This research aims to develop an appropriate and efficient nanocarrier, having the ability of interacting with and delivering CpG-oligodeoxynucleotides (CpG-ODNs) to tumor cells. CpG-ODNs activate Toll-like receptor 9 (TLR9), which...
Targeted delivery of CPG-oligodeoxynucleotide to breast cancer cells by poly-amidoamine dendrimer-modified magnetic nanoparticles Taghavi Pourianazar, Negar; Gündüz, Ufuk; Gündüz, Güngör; Department of Biotechnology (2016) One major application of nanotechnology in cancer treatment involves designing nanoparticles to deliver drugs, oligonucleotides, and genes to cancer cells. Nanoparticles should be engineered so that they could target and destroy tumor cells with minimal damage to healthy tissues. This research aims to develop an appropriate and efficient nanocarrier, having the ability of interacting with and delivering CpG-oligodeoxynucleotides (CpG-ODNs) to tumor cells. CpG-ODNs activate Toll-like receptor 9 (TLR9), which...
Nanoparticle-based drug delivery in cancer: the role of cell membrane structures Yalcin, Serap; Ozluer, Ozlem; Gündüz, Ufuk (2016-11-01) Development of novel drug-delivery systems aims to specifically deliver anticancer drugs to tumor tissues and improve the efficiency of chemotherapy, while minimizing side effects of drugs on healthy tissues and organs. However, drug-delivery systems are confronted by membrane barriers and multiple drug resistance in cancer cells. In recent years, the obtained results indicate an important role of lipids, proteins and carbohydrates in apoptosis, drug transport and the process of cellular uptake of nanoparti...
EFFORTS TOWARDS SYNTHESIS OF HYDROGEN SULFIDE ACTIVATED BODIPY BASED PDT AGENT Canyurt, Merve; Günbaş, Emrullah Görkem; Department of Chemistry (2022-5-13) Photodynamic Therapy (PDT) is an effective and minimally invasive method that has recently gained widespread acceptance as a new medical treatment for a variety of conditions. PDT uses photosensitizers in combination with a specific light source and molecular oxygen to form cytotoxic species that can damage organelles and cell membranes directly. The photodynamic reactions start with light absorption by the PS in the target tissue, which sets off a chain of photochemical events. In comparison to existing se...
2-Amino-2-deoxy-glucose conjugated cobalt ferrite magnetic nanoparticle (2DG-MNP) as a targeting agent for breast cancer cells Asik, Elif; Aslan, Tugba Nur; Volkan, Mürvet; Güray, Nülüfer Tülün (2016-01-01) In this study, 2-amino-2-deoxy-glucose (2DG) was conjugated to COOH modified cobalt ferrite magnetic nanoparticles (COOH-MNPs), which were designed to target tumor cells as a potential targetable drug/gene delivery agent for cancer treatment. According to our results, it is apparent that, 2DG labeled MNPs were internalized more efficiently than COOH-MNPs under the same conditions in all cell types (MDA-MB-231 and MCF-7 cancer and MCF-10A normal breast cells) (p < 0.001). Moreover, the highest amount of upta...

Citation Formats

K. N. Ozvural Sertcelik et al., “Superior Photodynamic Therapy of Colon Cancer Cells by Selenophene-BODIPY-Loaded Superparamagnetic Iron Oxide Nanoparticles,” ChemPhotoChem, pp. 0–0, 2022, Accessed: 00, 2022. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85135249624&origin=inward.