STORAX CONTAINING HYDROXYETHYL CHITOSAN -CARRAGEENAN HYDROGEL / ASYMMETRIC POLYCAPROLACTONE MEMBRANE BILAYER WOUND DRESSING

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2023-1-18

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Nakipoğlu, Mustafa

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Despite the advancement of modern technology, wound care is still based on traditional methods such as suture, staple and gauze around the world. Although, these methods provide affordable treatment for various types of wounds, they fall short in easy and effective treatment to facilitate healing process. Enabling a quicker and more convenient wound healing necessitates a comprehensive approach to wound dressing development to include simple yet multifunctional and versatile designs. In this work, we focused on the development of a multifunctional wound dressing composed of two layers; polydopamine coated asymmetric polycaprolactone membrane (PCL-DOP) and Liquidambar orientalis Mill. storax loaded hydroxyethyl chitosan (HECS)-carrageenan (kC) based hydrogel (HECS kC). PCL-DOP membrane was prepared by non-solvent induced phase separation (NIPS) followed by polydopamine coating and demonstrated an excellent barrier against bacteria while allowing optimal oxygen and water vapor exchange in addition to good adhesive-cohesive properties. Storax loaded HECS-kC hydrogel, on the other hand, was tested on different pH environment in vitro and optimized to provide necessary conditions to facilitate wound healing. The hydrogels showed ultra-stretchability, capability to absorb wound exudates, allow oxygen and water vapor transmission while the storax incorporation enabled enhanced antimicrobial and antioxidant activity. Furthermore, rat full-thickness skin defect model showed that the developed bilayer wound dressing could significantly facilitate wound healing compared to Tegaderm and control groups. This study displays that the bilayered wound dressing have a potential to be used a simple and effective wound care system.

Subject Keywords

Liquidambar orientalis Mill., Polycaprolactone, Chitosan, Carrageenan, Wound dressing

URI

https://hdl.handle.net/11511/102071

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Graduate School of Natural and Applied Sciences, Thesis

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Citation Formats

M. Nakipoğlu, “STORAX CONTAINING HYDROXYETHYL CHITOSAN -CARRAGEENAN HYDROGEL / ASYMMETRIC POLYCAPROLACTONE MEMBRANE BILAYER WOUND DRESSING,” Ph.D. - Doctoral Program, Middle East Technical University, 2023.