Nakipoğlu, Mustafa
Despite the advancement of modern technology, wound care is still based on traditional methods such as suture, staple and gauze around the world. Although, these methods provide affordable treatment for various types of wounds, they fall short in easy and effective treatment to facilitate healing process. Enabling a quicker and more convenient wound healing necessitates a comprehensive approach to wound dressing development to include simple yet multifunctional and versatile designs. In this work, we focused on the development of a multifunctional wound dressing composed of two layers; polydopamine coated asymmetric polycaprolactone membrane (PCL-DOP) and Liquidambar orientalis Mill. storax loaded hydroxyethyl chitosan (HECS)-carrageenan (kC) based hydrogel (HECS kC). PCL-DOP membrane was prepared by non-solvent induced phase separation (NIPS) followed by polydopamine coating and demonstrated an excellent barrier against bacteria while allowing optimal oxygen and water vapor exchange in addition to good adhesive-cohesive properties. Storax loaded HECS-kC hydrogel, on the other hand, was tested on different pH environment in vitro and optimized to provide necessary conditions to facilitate wound healing. The hydrogels showed ultra-stretchability, capability to absorb wound exudates, allow oxygen and water vapor transmission while the storax incorporation enabled enhanced antimicrobial and antioxidant activity. Furthermore, rat full-thickness skin defect model showed that the developed bilayer wound dressing could significantly facilitate wound healing compared to Tegaderm and control groups. This study displays that the bilayered wound dressing have a potential to be used a simple and effective wound care system.


EGF containing gelatin-based wound dressings
Ulubayram, K; Cakar, AN; Korkusuz, P; Ertan, C; Hasırcı, Nesrin (2001-06-01)
In case of bulk loss of tissue or non-healing wounds such as burns, trauma, diabetic, decubitus and venous stasis ulcers, a proper wound dressing is needed to cover the wound area, protect the damaged tissue, and if possible to activate the cell proliferation and stimulate the healing process. In this study, synthesis of a novel polymeric bilayer wound dressing containing epidermal growth-factor (EGF)-loaded microspheres was aimed. For this purpose, a natural, nontoxic and biocompatible material, gelatin, w...
Xanthan-gelatin and xanthan-gelatin-keratin wound dressings for local delivery of vitamin c
Demir, Gizem Çiğdem; Tezcaner, Ayşen; Department of Biotechnology (2021-1-10)
In recent years, functional dressings that can protect the wound area from dehydration, support healing (interactive), and protect the wound against infections have gained importance instead of dry and passive dressings. In this study, it was aimed to develop temporary xanthan gelatin (XGH) and keratin xanthan gelatin hydrogels (KXGHs) that have high exudate absorption capacity, oxygen permeability, and applicability as a wound dressing for medical applications. Firstly, xanthan gelatin hydrogels were produ...
Xanthan-gelatin and xanthan-gelatin-keratin wound dressings for local delivery of Vitamin C
Demir, Gizem Cigdem; Erdemli, Özge; Keskin, Dilek; Tezcaner, Ayşen (2022-02-01)
Recently, functional dressings that can protect the wound area from dehydration and bacterial infection and support healing have gained importance in place of passive dressings. This study aimed to develop temporary and regenerative xanthan/gelatin (XGH) and keratin/xanthan/gelatin hydrogels (KXGHs) that have high absorption capacity and applicability as a wound dressing that can provide local delivery of Vitamin C (VC). Firstly, xanthan/gelatin hydrogels were produced by crosslinking with different glycero...
Biodegradable hydroxyapatite - Polymer composites
Durucan, Caner (2001-04-01)
The fracture of bone due to trauma or due to natural aging is one of the most frequent types of tissue failures. Treatment frequently requires the implantation of ct temporary or permanent prosthesis. The implanted materials may include the components of artificial joints, plates, and screws for fracture fixation. Typically, such implants are intended only to provide structural support or to serve as templates for bone re-growth. In general they are intended to remain in place for the life of the patient or...
Collagen/gold nanoparticle nanocomposites: A potential skin wound healing biomaterial
Akturk, Omer; Kismet, Kemal; Yasti, Ahmet C.; Kuru, Serdar; Duymus, Mehmet E.; Kaya, Feridun; Caydere, Muzaffer; Hucumenoglu, Sema; Keskin, Dilek (2016-08-01)
In this study, nanocomposite collagen scaffolds incorporating gold nanoparticles (AuNPs) were prepared for wound healing applications. Initially, dose (<20ppm) and size (>20nm) of AuNPs that were not cytotoxic on HaCat keratinocytes and 3T3 fibroblasts were determined. Both collagen sponges and AuNP-incorporated nanocomposites (CS-Au) were cross-linked with glutaraldehyde (CS-X and CS-AuX). Incorporation of AuNPs into cross-linked scaffolds enhanced their stability against enzymatic degradation and increase...
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