Peptide-based drug systems /

Download
2017
Parlak, Melek
The increasing appeal of safe, cheap and effective treatments against various type of diseases has paved the way for the discovery and development of innovative peptide-based drug and drug delivery systems. The relative ease with which peptide based-materials can be synthesized and the wide range of synthetic techniques available have ensured that these materials can be tuned to adopt specific conformation or modified to contain specific functional groups. Our major focus in this thesis is developing peptides with different scaffolds. In one study, we synthesized small peptides that mimic the correctly folded state of the fusion protein of the Respiratory syncytial virus (RSV) that causes respiratory tract infections. As small peptides generally do not retain their native conformation, they were stabilized through construction of intramolecular bridges that hold the peptides in the right conformation. A various type and size of intramolecular bridges were established in different part of the peptide sequences. Constrained peptides that both showing binding against specific antibodies and having helical structures as in their native structures were covalently linked to carrier protein for further immunological studies. In another study, poor therapeutic properties of pro-apoptotic Smac peptide (AVPIAQK) were improved. Apoptotic peptide was fused to a well-known octaarginine cell-penetrating peptide for promoting its access to a cell's interior. Smac and octaarginine containing linear, monocyclic and bicyclic peptides were successfully synthesized. The biological properties of designed peptides in terms of cell-permeability, cytotoxicity and apoptotic efficiency were studied. As a final study, anthracene containing peptide nanofibers and peptide vesicles were designed, synthesized and changes in their self-assembled structure upon light exposure at 365 nm were investigated. It was proved that such systems have a potential as light-driven drug delivery.

Suggestions

Biopolymer based micro/nanoparticles as drug carriers for the treatment of skin diseases
Eke, Gözde; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin; Department of Micro and Nanotechnology (2011)
Controlled drug delivery systems are becoming increasingly interesting with the contribution of nanotechnology. In the case of transdermal applications the greatest limitation is the highly impermeable outermost layer of the skin, the stratum corneum. One promising method of controlled transdermal drug delivery of the skin therapeutics is the use of nanoparticles as carriers. Encapsulation of the drug, as opposed to classical topical application of creams or emulsions, allows the drug to diffuse into hair f...
Synthesis and characterization of fatty acid based hyperbranched polymers for anti-cancer drug delivery
Güç, Esra; Gündüz, Ufuk; Department of Biology (2008)
Conventional methods of chemotherapy requires novel therapy systems due to serious side effects and inefficiency of drug administration. In recent years many studies are carried out to improve drug delivery systems. Polymers are one of the most important elements for drug delivery research due to their versatility. By the discovery of dendritic polymers, drug delivery studies gained a new vision. Highly branched monodisperse structure, multiple sites of attachment, well-defined size and controllable physica...
Surface functionalization of SBA - 15 particles for amoxicillin delivery
Sevimli, Filiz F; Yılmaz, Ayşen; Department of Chemistry (2011)
There are several studies in order to control drug delivery, decrease the toxicity of drugs and also for novel biomedical applications. It is necessary to be able to control the release of the drug within the body by using drug delivery systems. Mesoporous silica compounds have only been discovered twenty years ago and they have already attracted many researchers to study these materials for several applications. SBA-15 particles have a highly ordered regular structure and are a good matrix for guest-host a...
Controlled doxorubicin delivery from photoresponsive liposomes carrying vitamin A derivatives /
Heper, Senem; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin; Department of Biotechnology (2014)
Drug delivery systems (DDS) have been an attractive approach to eliminate the drawbacks of conventional drug administration. Controlled and photoresponsive drug delivery systems have a special advantage; they deliver drugs more effectively. Liposomes are mostly preferred as drug carriers due to their ability to carry both hydrophilic and hydrophobic drugs, their being non-toxic and non-immunogenic. In this study, photoresponsive liposomes were prepared by incorporating vitamin A derivatives into the lipid b...
Smart Drug Delivery Systems in Cancer Therapy
ÜNSOY, GÖZDE; Gündüz, Ufuk (2018-01-01)
Background: Smart nanocarriers have been designed for tissue-specific targeted drug delivery, sustained or triggered drug release and co-delivery of synergistic drug combinations to develop safer and more efficient therapeutics.
Citation Formats
M. Parlak, “Peptide-based drug systems /,” Ph.D. - Doctoral Program, Middle East Technical University, 2017.