Advances in Solid Phase Microextraction and Perspective on Future Directions

Reyes-Garces, Nathaly
Gionfriddo, Emanuela
Gmez-Rios, German Augusto
Alam, Md. Nazmul
Boyacı, Ezel
Bojko, Barbara
Singh, Varoon
Grandy, Jonathan
Pawliszyn, Janusz


Development of non-invasive and biocompatible thin film micro-extraction contact lens-type devices compatible for in vivo metabolomics investigations from eye surface
Nalbant, Atakan Arda; Boyacı, Ezel; Department of Chemistry (2020-7)
In this thesis, the aim was to develop biocompatible extractive thin films in contact lens geometries with application potential for in vivo sampling of small molecules from the eye surface with the ultimate goal of being suitable for untargeted metabolomics and biomarker discoveries. For this purpose, polydimethylsiloxane was functionalized with amine-containing groups using in situ modification approach and thin films were characterized with Fourier transform infrared spectroscopy, energy dispersive x-ray...
Investigation of extraction methodologies for quantitative determination of polycyclic aromatic hydrocarbons in sediments
Topal, Tansel; Tuncel, Semra G.; Department of Chemistry (2011)
The extraction procedures for the determination of polycyclic aromatic hydrocarbons (PAH) concentrations in sediment samples had been developed by using GC-FID and GC-MS. The optimized methods were soxhlet extraction, ultrasonic bath extraction and solid phase micro extraction (SPME). In order to search out the main factors affecting extraction efficiencies of the methods, factorial design was used. The best extraction method was chosen and optimum values for main factors were selected for the development o...
Development of a genetic material transfer approach for gene therapy
Ayaz, Şerife; Hasırcı, Vasıf Nejat; Department of Biotechnology (2005)
This thesis is focused on the development of a gene delivery system, especially for the purpose of DNA vaccination. DNA expression vectors have the potential to be useful therapeutics for a wide variety of applications. A carrier system was designed to realize the delivery of genes to cells and the promotion of controlled adequate expression in the target cells. The low gene delivery efficiency observed with systems composed of polyplexes is mainly due to low stability of polycation e.g polyethylenimine-DNA...
Fundamental Concepts of Performance Based Earthquake Engineering
Sucuoğlu, Haluk (null; 2015-08-29)
In modern earthquake engineering, seismic performance properties are more important than the resistance properties of structures. Seismic performance of a structure is related to the expected damage level under an earthquake excitation, and how this damage relates to safety and use of the building. Accordingly, estimation of member deformations becomes more critical than the estimation of internal forces since the deformations in the post elastic regions of the structure are well correlated with damage in t...
Incorporation of DSSC in real time congestion management
Günay, Ramazan; Göl, Murat; Department of Electrical and Electronics Engineering (2018)
Congestion became an inseparable part of power system operation, after deregulation of the monopolistic electric market. Presence of congestion causes rise of local market powers, and hence it is avoided during day-ahead planning. However, it is possible to encounter congestion during real-time operation because of the uncertain behavior of the loads. Although, the congestion can be detected in real-time, its management is not trivial as it requires change of topology or generation dispatch. This work propo...
Citation Formats
N. Reyes-Garces et al., “Advances in Solid Phase Microextraction and Perspective on Future Directions,” ANALYTICAL CHEMISTRY, pp. 302–360, 2018, Accessed: 00, 2020. [Online]. Available: