Advances in Solid Phase Microextraction and Perspective on Future Directions

Reyes-Garces, Nathaly
Gionfriddo, Emanuela
Gmez-Rios, German Augusto
Alam, Md. Nazmul
Boyacı, Ezel
Bojko, Barbara
Singh, Varoon
Grandy, Jonathan
Pawliszyn, Janusz


Basics of massive spin-2 theories
Kürekçi, Şahin; Tekin, Bayram; Department of Physics (2015)
In this thesis, basics of massive spin-2 theories are studied. The theory of general relativity cannot explain some problems in very small and in very large scales and it needs a modification. The way of modifying general relativity by giving mass to the propagating particle graviton is called massive gravity. The first correct massive gravity theory is the linear theory written by Fierz and Pauli. However, later on it has been found that this theory does not match up with the physical predictions of genera...
Development of mass spectrometric methods for negative ion studies
Hacaloglu, Jale; Department of Chemistry (1987)
Development of non-invasive and biocompatible thin film micro-extraction contact lens-type devices compatible for in vivo metabolomics investigations from eye surface
Nalbant, Atakan Arda; Boyacı, Ezel; Department of Chemistry (2020-7)
In this thesis, the aim was to develop biocompatible extractive thin films in contact lens geometries with application potential for in vivo sampling of small molecules from the eye surface with the ultimate goal of being suitable for untargeted metabolomics and biomarker discoveries. For this purpose, polydimethylsiloxane was functionalized with amine-containing groups using in situ modification approach and thin films were characterized with Fourier transform infrared spectroscopy, energy dispersive x-ray...
Investigation of extraction methodologies for quantitative determination of polycyclic aromatic hydrocarbons in sediments
Topal, Tansel; Tuncel, Semra G.; Department of Chemistry (2011)
The extraction procedures for the determination of polycyclic aromatic hydrocarbons (PAH) concentrations in sediment samples had been developed by using GC-FID and GC-MS. The optimized methods were soxhlet extraction, ultrasonic bath extraction and solid phase micro extraction (SPME). In order to search out the main factors affecting extraction efficiencies of the methods, factorial design was used. The best extraction method was chosen and optimum values for main factors were selected for the development o...
Development of a genetic material transfer approach for gene therapy
Ayaz, Şerife; Hasırcı, Vasıf Nejat; Department of Biotechnology (2005)
This thesis is focused on the development of a gene delivery system, especially for the purpose of DNA vaccination. DNA expression vectors have the potential to be useful therapeutics for a wide variety of applications. A carrier system was designed to realize the delivery of genes to cells and the promotion of controlled adequate expression in the target cells. The low gene delivery efficiency observed with systems composed of polyplexes is mainly due to low stability of polycation e.g polyethylenimine-DNA...
Citation Formats
N. Reyes-Garces et al., “Advances in Solid Phase Microextraction and Perspective on Future Directions,” ANALYTICAL CHEMISTRY, pp. 302–360, 2018, Accessed: 00, 2020. [Online]. Available: