The serum immunoglobulin G glycosylation signature of gastric cancer

Date

2015-03-01

Author

Ruhaak, L. Renee
Barkauskas, Donald A.
Torres, Javier
Cooke, Cara L.
Wu, Lauren D.
Stroble, Carol
Özcan Kabasakal, Süreyya
Williams, Cynthia C.
Camorlinga, Margarita
Rocke, David M.
Lebrilla, Carlito B.
Solnick, Jay V.

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Biomarkers may facilitate detection of gastric cancer at an earlier stage and reduce mortality. Here we sought to determine if the glycosylation profile of serum immunoglobulin G (IgG) could distinguish patients with non-atrophic gastritis (NAG), duodenal ulcer (DU) and gastric cancer (GC). Serum IgG was released and analyzed using nano-LC–TOF mass spectrometry. Statistically significant false discovery rate (FDR)-adjusted p-values were observed for 18 glycans, eight that differed significantly between NAG and GC, three that distinguished NAG from DU, and eight that differed between DU and GC. The IgG glycosylation signature may be useful as a predictive marker for gastric cancer.

Subject Keywords

Biochemistry

URI

https://hdl.handle.net/11511/36372

Journal

EuPA Open Proteomics

DOI

https://doi.org/10.1016/j.euprot.2014.11.002

Collections

Department of Chemistry, Article

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Citation Formats

L. R. Ruhaak et al., “The serum immunoglobulin G glycosylation signature of gastric cancer,” EuPA Open Proteomics, pp. 1–9, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/36372.