Electrospun silk doped with selenium nanoparticles to enhance antibacterial properties

Chung, Stanley
Stolzoff, Mıchelle
Ercan, Batur
Webster, Thomas
Silk is a naturally derived biomaterial that has shown good properties for skin applications. However, unmodified silk has been shown to promote bacterial growth which is a major concern for any open wound skin application. Here, we propose for the first time, an electrospun silk scaffold doped with selenium nanoparticles to address this issue. Selenium nanoparticles have been shown to possess excellent antibacterial properties. By incorporating selenium nanoparticles into silk, we expect to retain silk's beneficial skin healing properties while increasing its antibacterial ability.
AIChE Annual Meeting (2015)


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Skin is the largest organ by surface area and provides the primary defense against microbes, viruses, and other harmful environmental interactions. Silk is widely used as a cosmetic additive and has been investigated for skin regeneration because of its beneficial properties for skin application : promotion of collagen synthesis, re-epithelialization, wound healing, atopic dermatitis alleviation, and scar reduction. However, pure silk shows negligible or even negative antibacterial properties. Here, we prop...
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Silk possesses many beneficial wound healing properties, and electrospun scaffolds are especially applicable for skin applications, due to their smaller interstices and higher surface areas. However, purified silk promotes microbial growth. Selenium nanoparticles have shown excellent antibacterial properties and are a novel antimicrobial chemistry. Here, electrospun silk scaffolds were doped with selenium nanoparticles to impart antibacterial properties to the silk scaffolds. Results showed significantly im...
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Citation Formats
S. Chung, M. Stolzoff, B. Ercan, and T. Webster, “Electrospun silk doped with selenium nanoparticles to enhance antibacterial properties,” Salt Lake City, United States, 2015, p. 595, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/84181.