Electrospun silk doped with selenium nanoparticles to enhance antibacterial properties

Date

2015-12-31

Author

Chung, Stanley
Stolzoff, Mıchelle
Ercan, Batur
Webster, Thomas

Metadata

Show full item record

Item Usage Stats

153
views

0
downloads

Silk is a naturally derived biomaterial that has shown good properties for skin applications. However, unmodified silk has been shown to promote bacterial growth which is a major concern for any open wound skin application. Here, we propose for the first time, an electrospun silk scaffold doped with selenium nanoparticles to address this issue. Selenium nanoparticles have been shown to possess excellent antibacterial properties. By incorporating selenium nanoparticles into silk, we expect to retain silk's beneficial skin healing properties while increasing its antibacterial ability.

URI

https://hdl.handle.net/11511/84181
https://www.scopus.com/record/display.uri?eid=2-s2.0-84969716718&origin=resultslist&sort=plf-f&src=s&st1=&st2=&sid=513f72517ac82f4ab7c75cc59434d2e8&sot=b&sdt=b&sl=101&s=TITLE-ABS-KEY%28Electrospun+Silk+Doped+with+Selenium+Nanoparticles+to+Enhance+Antibacterial+Properties%29&relpos=0&citeCnt=0&searchTerm=

Conference Name

AIChE Annual Meeting (2015)

Collections

Department of Metallurgical and Materials Engineering, Conference / Seminar

Suggestions

OpenMETU
Core

Electrospun Silk Doped with Selenium for Antibacterial Skin Applications Chung, Stanley; Ercan, Batur; Webster, Thomas J.; Phong Tran, Phong Tran (2014-01-01) Skin is the largest organ by surface area and provides the primary defense against microbes, viruses, and other harmful environmental interactions. Silk is widely used as a cosmetic additive and has been investigated for skin regeneration because of its beneficial properties for skin application : promotion of collagen synthesis, re-epithelialization, wound healing, atopic dermatitis alleviation, and scar reduction. However, pure silk shows negligible or even negative antibacterial properties. Here, we prop...
Electrospun multifunctional diclofenac sodium releasing nanoscaffold Nikkola, L.; Seppala, J.; Harlin, A.; Ndreu, A.; Ashammakhi, N. (American Scientific Publishers, 2006-09-01) Electrospinning is a method utilized to produce nano-scale fibers for tissue engineering applications. A variety of cells are attracted by nano scale surfaces and structures probably due to the similarity of their natural environment scale. In this study, diclofenac sodium (DS) releasing nanofibers; were manufactured via electrospinning process. Poly(95 epsilon-capro/5 D,L-lactide) was dissolved into acetic acid to form a 20% w/v solution. 2% w/w of DS was then added into the polymer solution and stirred ho...
Addition of Selenium Nanoparticles to Electrospun Silk Scaffold Improves the Mammalian Cell Activity While Reducing Bacterial Growth Chung, Stanley; Ercan, Batur; Roy, Amit K.; Webster, Thomas J. (2016-07-14) Silk possesses many beneficial wound healing properties, and electrospun scaffolds are especially applicable for skin applications, due to their smaller interstices and higher surface areas. However, purified silk promotes microbial growth. Selenium nanoparticles have shown excellent antibacterial properties and are a novel antimicrobial chemistry. Here, electrospun silk scaffolds were doped with selenium nanoparticles to impart antibacterial properties to the silk scaffolds. Results showed significantly im...
Electrospun nanofibrous scaffolds for tissue engineering Ndreu, Albana; Hasırcı, Vasıf Nejat; Department of Biotechnology (2007) In this study a microbial polyester, poly(3-hydroxybutyrate-co-3- hydroxyvalerate) (PHBV), and its blends were wet or electrospun into fibrous scaffolds for tissue engineering. Wet spun fiber diameters were in the low micrometer range (10-50 μm). The polymer concentration and the stirring rate affected the properties the most. The optimum concentration was determined as 15% (w/v). Electrospun fiber diameters, however, were thinner. Solution viscosity, potential, distance between the syringe tip and the coll...
Catalytic Ozonation of Dye Solutions in a Semi-Batch Reactor Pirgalıoğlu, Saltuk; Özbelge, Ayşe Tülay; Department of Chemical Engineering (2008) Treatment of textile wastewaters containing dye materials using the conventional methods based on biological treatment is not possible. In order to overcome this problem, ozonation based on the oxidation of organic pollutants with ozone gas dissolved in aqueous phase have been studied widely. Catalytic ozonation and advanced oxidation processes (AOP) are also used in order to increase the efficiency of sole ozonation In this work, catalytic ozonation processes in the presence of Copper Sulfide (CuS) powder ...

Citation Formats

S. Chung, M. Stolzoff, B. Ercan, and T. Webster, “Electrospun silk doped with selenium nanoparticles to enhance antibacterial properties,” Salt Lake City, United States, 2015, p. 595, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/84181.