Structural, mechanical and biological properties of hydroxyapatite-zirconia-lanthanum oxide composites

Date

2016-11-01

Author

Khoshsima, Sina
Yilmaz, Bengi
Tezcaner, Ayşen
Evis, Zafer

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

216
views

0
downloads

Novel hydroxyapatite-zirconia-lanthanum oxide composites for bioceramic applications were synthesized and their structural, mechanical and biological properties were studied. Pure HA was produced via precipitation method and the composites were obtained by several fabrication steps: powder milling, mixing, cold pressing and sintering at 1100 degrees C for 1 h. The experimental results indicated that the composites consisted of hydroxyapatite as the main phase with a trace amount of tricalcium phosphate. Calcium zirconate (CaZrO3) was also formed by the reaction between zirconia and calcium oxide (CaO) which is the thermal decomposition product of hydroxyapatite. Addition of zirconia and lanthanum oxide resulted a more loose and porous structure on the surface. The diametral tensile strength of the composites was higher with respect to pure hydroxyapatite. The microhardness of the composites, except the one with the composition of 90 wt% HA and 10 wt% Zr, was relatively lower than that of pure HA but these composites had higher machinability. Cell culture studies with osteoblast-like Saos-2 cell line showed that composites and pure hydroxyapatite were biocompatible. Based on these findings, hydroxyapatite-zirconia-lanthanum oxide composites hold potential to be used in hard tissue replacement and regeneration therapies.

Subject Keywords

Biomedical applications, ZrO2, Apatite, Sintering

URI

https://hdl.handle.net/11511/39236

Journal

CERAMICS INTERNATIONAL

DOI

https://doi.org/10.1016/j.ceramint.2016.07.041

Collections

Department of Engineering Sciences, Article

Suggestions

OpenMETU
Core

Structural, mechanical, and biocompatibility investigations of yttrium and fluoride doped nano hydroxyapatite Burçin, Başar; Evis, Zafer; Department of Engineering Sciences (2009) In this study, it was aimed to investigate the structural, mechanical and biological properties of nano hydroxyapatite (HA) doped with yttrium and fluoride with different compositions. HAs were synthesized by precipitation method. After sintering at 900oC, 1100oC or 1300oC for 1 hour, the structural properties of HAs were investigated by XRD, FTIR spectroscopy and SEM. High relative densities (above 88 % of relative density) were achieved after sintering. No second phases were observed in XRD measurements. ...
Structural and dynamical properties of liquid Pd-Ag alloys Kart, HH; Tomak, Mehmet; Uludogan, M; Cagin, T (World Scientific Pub Co Pte Lt, 2004-06-30) Structural and dynamical properties of Pd, Ag pure liquid metals and especially PdxAg1-x, alloys are studied by the molecular dynamics simulation. The effects of temperature and concentration on the liquid properties of PdxAg1-x, are analyzed. Sutton-Chen (SC) and Quantum Sutton-Chen (Q-SC) many-body potentials are used as interatomic interactions. The calculated diffusion constants and viscosities are in good agreement with the available experimental data and theoretical calculations. The coefficients of A...
Fabrication and cellular interactions of nanoporous tantalum oxide Uslu, Ece; Garipcan, Bora; Ercan, Batur (Wiley, 2020-10-01) Tantalum possesses remarkable chemical and mechanical properties, and thus it is considered to be one of the next generation implant materials. However, the biological properties of tantalum remain to be improved for its use in tissue engineering applications. To enhance its cellular interactions, implants made of tantalum could be modified to obtain nanofeatured surfaces via the electrochemical anodization process. In this study, anodization parameters were adjusted to obtain a nanoporous surface morpholog...
Structural, thermodynamical, and transport properties of undercooled binary Pd-Ni alloys Kart, S. Ozdemir; Tomak, Mehmet; Uludogan, M.; Cagin, T. (Elsevier BV, 2006-11-05) The solidification properties of Pd-Ni alloys are studied with constant-pressure, constant-temperature (TPN), and constant-volume, constant-temperature (TVN) molecular dynamics simulations based on quantum Sutton-Chen potential. Whether the system forms the glass structure or it transforms into ordered state is checked at various cooling rates ranging from 10 K/ps to 0.05 K/ps. The effect of concentration and cooling rates on the glass transition temperature is examined. The behavior of heat capacity at con...
Fabrication of functionalized citrus pectin/silk fibroin scaffolds for skin tissue engineering Türkkan, Sibel; Atila, Deniz; Akdağ, Akın; Tezcaner, Ayşen (Wiley, 2018-10-01) In this study, novel porous three-dimensional (3D) scaffolds from silk fibroin (SF) and functionalized (amidated and oxidized) citrus pectin (PEC) were developed for skin tissue engineering applications. Crosslinking was achieved by Schiff's reaction in borax presence as crosslinking coordinating agent and CaCl2 addition. After freeze-drying and methanol treatment, plasma treatment (10 W, 3 min) was applied to remove surface skin layer formed on scaffolds. 3D matrices had high porosity (83%) and interconnec...

Citation Formats

S. Khoshsima, B. Yilmaz, A. Tezcaner, and Z. Evis, “Structural, mechanical and biological properties of hydroxyapatite-zirconia-lanthanum oxide composites,” CERAMICS INTERNATIONAL, pp. 15773–15779, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/39236.