Sustained release of a model macromolecule from preparations with erodible core

Date

1988-9

Author

Hasırcı, Vasıf Nejat
Kamel , Ibrahim

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A series of sustained release tablets were prepared which consisted of a water-soluble core and a highly hydrophobie coat. Release of a macromolecule. Spectrum Orange, from this preparation was studied. It was found that release was controlled by the coat composition and coating solution viscosity. SEM and optical microscopy of the tablets indicated that the coats contained pores on the surface which penetrated in towards the centre of the core. It was deduced that the almost zero order release of macromolecules from these tablets was basically through these pores and not by diffusion through the polymer matrix.

Subject Keywords

Biophysics, Mechanics of Materials, Bioengineering, Biomaterials, Ceramics and Composites

URI

https://hdl.handle.net/11511/51865

Journal

Biomaterials

DOI

https://doi.org/10.1016/0142-9612(88)90007-5

Collections

Department of Biology, Article

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Citation Formats

V. N. Hasırcı and I. Kamel, “Sustained release of a model macromolecule from preparations with erodible core,” Biomaterials, pp. 424–428, 1988, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/51865.