Vancomycin containing PLLA/beta-TCP controls experimental osteomyelitis in vivo

Kankilic, Berna
Korkusuz, Feza
Background: Implant-related osteomyelitis (IRO) is recently controlled with local antibiotic delivery systems to overcome conventional therapy disadvantages. In vivo evaluation of such systems is however too little.


Vancomycin release from poly(D,L-lactide) and poly(lactide-co-glycolide) disks
Ozalp, Y; Ozdemir, N; Hasırcı, Vasıf Nejat (2002-01-01)
A biodegradable and biocompatible polymeric system was developed for the controlled release of vancomycin for the treatment of brain abscesses. Poly(D,L-lactic acid) (PLA) and its copolymers poly( lactide-co-glycolide) PLGA 90: 10 and PLGA 70: 30, were prepared. Polymer disks containing vancomycin (VN) were prepared by solvent casting from methylene chloride solutions. Degradation of the polymer disk was studied by scanning electron microscopy, NMR and GPC. SEM revealed an increasing degree of degradation w...
Vancomycin Containing PDLLA and PLGA/β-TCP Inhibit Biofilm Formation but Do Not Stimulate Osteogenic Transformation of Human Mesenchymal Stem Cells
Kankilic, Berna; Bayramlı, Erdal; KORKUSUZ, PETEK; EROĞLU, HAKAN; ŞENER, BURÇİN; Mutlu, Pelin; KORKUSUZ, FEZA (2022-07-01)
Aims: Chronic osteomyelitis, including implant-related prosthetic joint infection, is extremely difficult to cure. We develop vancomycin containing release systems from poly(d,l-lactide) (PDLLA) and poly(d,l-lactide-co-glycolide) (PLGA) composites with beta-tricalcium phosphate (β-TCP) to treat methicillin-resistant Staphylococcus aureus osteomyelitis. We ask whether vancomycin containing PDLLA/β-TCP and PLGA/β-TCP composites will prevent early biofilm formation, allow cell proliferation and osteogenic diff...
Glucose-Responsive Trehalose Hydrogel for Insulin Stabilization and Delivery
Lee, Juneyoung; Ko, Jeong Hoon; Mansfield, Kathryn M.; Nauka, Peter C.; Bat, Erhan; Maynard, Heather D. (Wiley, 2018-05-01)
Effective delivery of therapeutic proteins is important for many biomedical applications. Yet, the stabilization of proteins during delivery and long-term storage remains a significant challenge. Herein, a trehalose-based hydrogel is reported that stabilizes insulin to elevated temperatures prior to glucose-triggered release. The hydrogel is synthesized using a polymer with trehalose side chains and a phenylboronic acid end-functionalized 8-arm poly(ethylene glycol) (PEG). The hydroxyls of the trehalose sid...
Synthesis and characterization of fatty acid based hyperbranched polymers for anti-cancer drug delivery
Güç, Esra; Gündüz, Ufuk; Department of Biology (2008)
Conventional methods of chemotherapy requires novel therapy systems due to serious side effects and inefficiency of drug administration. In recent years many studies are carried out to improve drug delivery systems. Polymers are one of the most important elements for drug delivery research due to their versatility. By the discovery of dendritic polymers, drug delivery studies gained a new vision. Highly branched monodisperse structure, multiple sites of attachment, well-defined size and controllable physica...
OZDEMIR, AYSE; Acar, Aybar Can; Department of Bioinformatics (2021-9-07)
Polypharmacy is an essential practice in today’s therapeutics, especially in the care of older population. Most polypharmacy-induced drug-drug interactions (DDIs) are often discovered after drugs are put on the market. Health problems and economic burden due to unpredicted DDIs put the health system in a difficult situation. Therefore, increasing the predictability of DDIs has become one of the most critical concerns towards improving treatment success. Being dependent on several underlying parameters makes...
Citation Formats
B. Kankilic, E. BİLGİÇ, P. KORKUSUZ, and F. Korkusuz, “Vancomycin containing PLLA/beta-TCP controls experimental osteomyelitis in vivo,” JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, pp. 0–0, 2014, Accessed: 00, 2020. [Online]. Available: