Electrospun polyacrylonitrile nanofibrous biomaterials

Date

2009-11-01

Author

Ren, Xuehong
Akdağ, Akın
Zhu, Changyun
Kou, Lei
Worley, S. D.
Huang, T. S.

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An N-halamine precursor, 3-(5'-methyl-5'-hydantoinyl)acetanilide (1), was synthesized in our laboratory and loaded onto electrospun polyacrylonitrile fiber to prepare nanosized biocidal materials, which could be rendered antimicrobial by exposure to household bleach. Differential scanning calorimetry was used to study the thermal properties of the nanofibers with and without the N-halamine precursor and its chlorinated derivative loaded. Scanning electron microscopy demonstrated that the ultrafine fibers formed with diameters from 250 to 600 nm. Chlorinated nanofibrous mats composed of the fibers were challenged with Staphylococcus aureus (ATCC 6538) and Escherichia coli O157:H7 (ATCC 43895); they showed promising inactivation efficacies against the two bacterial species within 5 minutes of contact. Potential uses of the antimicrobial fibers include filters for industrial water and air disinfection and protective clothing. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 91A: 385-390,2009

Subject Keywords

Metals and Alloys, Biomaterials, Ceramics and Composites, Biomedical Engineering

URI

https://hdl.handle.net/11511/57659

Journal

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

DOI

https://doi.org/10.1002/jbm.a.32260

Collections

Department of Chemistry, Article

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Citation Formats

X. Ren, A. Akdağ, C. Zhu, L. Kou, S. D. Worley, and T. S. Huang, “Electrospun polyacrylonitrile nanofibrous biomaterials,” JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, pp. 385–390, 2009, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/57659.