Comparison of methods for prediction of prostate cancer in Turkish men with PSA levels of 0-10 ng/mL

Saka, O.
Purpose: Several concepts to improve the diagnostic accuracy of prostate specific antigen (PSA) for prediction of prostate cancer have been studied. The aim of this study was to examine and compare the methods used for improving the diagnostic accuracy of PSA in a country with low incidence of prostate cancer


A patient-oriented decision support framework and its application to biopsy decision for prostatic carcinoma
Gülkesen, Kemal Hakan; Saka, Osman; Department of Health Informatics (2009)
Serum PSA (Prostate Specific Antigen) level is used for prediction of prostatic carcinoma, but it suffers from weak sensitivity and specificity. We applied logistic regression, artificial neural networks, decision tree, and genetic algorithm to prostate cancer prediction problem to design a model for Turkish population. A hybrid model of logistic regression and decision tree has been designed. The model could prevent 33 biopsies (4.4% of our patients who have PSA level between 0 and 10) from our data set wi...
Examination of the dielectrophoretic spectra of MCF7 breast cancer cells and leukocytes
Çağlayan, Zeynep; Demircan Yalçın, Yağmur; Külah, Haluk (Wiley, 2020-03-01)
The detection of circulating tumor cells (CTCs) in blood is crucial to assess metastatic progression and to guide therapy. Dielectrophoresis (DEP) is a powerful cell surface marker-free method that allows intrinsic dielectric properties of suspended cells to be exploited for CTC enrichment/isolation from blood. Design of a successful DEP-based CTC enrichment/isolation system requires that the DEP response of the targeted particles should accurately be known. This paper presents a DEP spectrum method to inve...
Relationship between the nat genetic polymorphism and susceptibility to prostate cancer
Dilek, Derya; Güray, Tülin; Department of Biology (2008)
Prostate cancer (PCa) is one of the most prevelant cancers in males in many countries, increasing in frequency with age. PCa incidence and mortality rates are not evenly distributed worldwide. Family history is an established risk factor for prostate cancer and families demonstrating autosomal dominant or X-linked transmission of susceptibility have been observed. Although an increasing number of candidate genes or hereditary prostate cancer susceptibility have been identified, only 5 to 10 percent of prost...
Studies on the molecular mechanism of the drug metabolism in prostate cancer, pc3 cell lines
Dilek Kançağı, Derya; Güray, Tülin; Telci, Dilek; Department of Biotechnology (2014)
Metabolic changes observed in prostate cancer are very important for both the course of the event and therapeutic way to be decided. One of the effective chemotherapeutic agent showing antitumour activity against prostate cancer is Docetaxel. The metabolism of this drug is important in term of its effectiveness. In this study we determine the effect of CYP1A1, CYP3A4 and GSTP1 enzyme inhibitors on the efficacy of the docetaxel. For this purpose, the gene expressions and activities of these enzymes were anal...
Demirkaya, Damla; Gözen, Ayşe Gül; Antmen Altunsoy, Ezgi; Department of Molecular Biology and Genetics (2022-1-12)
Prostate cancer is the second most diagnosed cancer in men and relapse due to the metastasis of cancer cells is the main reason of the high number of deaths in prostate cancer patients. Thus, there is a growing need for a tumor model to study the prostate cancer metastasis. In this study, a 3D model consisting of two natural polymer hydrogels (methacrylated collagen and methacrylated hyaluronic acid) with tunable mechanical and chemical properties carrying spheroids of two different prostate cancer cell lin...
Citation Formats
K. H. GÜLKESEN, İ. T. KÖKSAL, U. BİLGE, and O. Saka, “Comparison of methods for prediction of prostate cancer in Turkish men with PSA levels of 0-10 ng/mL,” JOURNAL OF BUON, pp. 537–542, 2010, Accessed: 00, 2020. [Online]. Available: