Show/Hide Menu
Hide/Show Apps
anonymousUser
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Açık Bilim Politikası
Açık Bilim Politikası
Frequently Asked Questions
Frequently Asked Questions
Browse
Browse
By Issue Date
By Issue Date
Authors
Authors
Titles
Titles
Subjects
Subjects
Communities & Collections
Communities & Collections
Novel BODIPY-subphthalocyanine dyads with reasonable photodynamic therapy behaviours
Date
2020-08-01
Author
Kazan, Hasan Huseyin
Ozcan, Emrah
ÇOŞUT, BÜNYEMİN
YENİLMEZ ÇİFTÇİ, GÖNÜL
TANRIVERDİ EÇİK, Esra
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
3
views
0
downloads
In this study, a set of bio-compatible and NIR emissive BODIPY-subphthalocyanine dyads (SP-DBD1-3) that contain amphiphilic triethyleneglycol units supporting partial water solubility and red absorbing BODIPY monomers (DBD1-3) were prepared. The photophysical and photochemical activities of these monomers, including fluorescence behaviors, singlet oxygen production, absorption, and emission profiles were investigated. The effect of the presence of halogen atoms and the BODIPY unit in dyads on the ability of generating singlet oxygen was evaluated. BODIPY-subphthalocyanine dyads showed two absorption bands at about 550 nm and 650 nm and high singlet oxygen quantum yields (up to 91%) at room temperature. The weaker fluorescence emissions, shorter fluorescence lifetimes but better singlet oxygen production capacities of dyads compared to those of BODIPY monomers have been explainedviathe energy transfer process from the donor subphthalocyanine unit to the acceptor BODIPY part, supporting ISC. Also,in vitrostudies underlined that the novel compounds (DBD1,DBD2,SP-DBD-2, andSP-DBD3) were successful in terms of the induction of cell death under red light; however, they did not affect the cells in dark, indicating these compounds as agents that can be used in photodynamic therapyin vivoin further studies.
Subject Keywords
Materials Chemistry
,
General Chemistry
,
Catalysis
URI
https://hdl.handle.net/11511/67891
Journal
NEW JOURNAL OF CHEMISTRY
DOI
https://doi.org/10.1039/d0nj02455d
Collections
Department of Biology, Article