Novel BODIPY-subphthalocyanine dyads with reasonable photodynamic therapy behaviours

Kazan, Hasan Huseyin
Ozcan, Emrah
In this study, a set of bio-compatible and NIR emissive BODIPY-subphthalocyanine dyads (SP-DBD1-3) that contain amphiphilic triethyleneglycol units supporting partial water solubility and red absorbing BODIPY monomers (DBD1-3) were prepared. The photophysical and photochemical activities of these monomers, including fluorescence behaviors, singlet oxygen production, absorption, and emission profiles were investigated. The effect of the presence of halogen atoms and the BODIPY unit in dyads on the ability of generating singlet oxygen was evaluated. BODIPY-subphthalocyanine dyads showed two absorption bands at about 550 nm and 650 nm and high singlet oxygen quantum yields (up to 91%) at room temperature. The weaker fluorescence emissions, shorter fluorescence lifetimes but better singlet oxygen production capacities of dyads compared to those of BODIPY monomers have been explainedviathe energy transfer process from the donor subphthalocyanine unit to the acceptor BODIPY part, supporting ISC. Also,in vitrostudies underlined that the novel compounds (DBD1,DBD2,SP-DBD-2, andSP-DBD3) were successful in terms of the induction of cell death under red light; however, they did not affect the cells in dark, indicating these compounds as agents that can be used in photodynamic therapyin vivoin further studies.


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Reboxetine (RBX) electrochemical redox behavior at hanging mercury drop (HMDE) and glassy carbon electrodes (GCE) was studied in various pH Britton-Robinson universal buffers using cyclic voltammetry and square-wave voltammetry. RBX was reduced at the HMDE and oxidized at the GCE with reversible adsorption controlled and irreversible diffusion controlled processes respectively. The anodic peak is due to the amine and the cathodic peak may correspond to oxygen protonation. An oxidation reaction mechanism is ...
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Diffuse-reflectance FTIR results obtained with tert-amyl-methyl-ether (TAME), ethanol, methanol, i-amylenes and mixtures of i-amylenes with alcohols supported a Langmuir-Hinshelwood type reaction mechanism involving adsorbed i-amylene molecules, which form a bridged structure between the adsorbed alcohols and the -SO3H sites of Amberlyst-15. Number of available sites involved in the adsorption of i-olefins is drastically decreased with an increase in alcohol concentration. The reaction rate model, which was...
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Lorkovic, IM; Yılmaz, Ayşen; Yilmaz, GA; Zhou, XP; Laverman, LE; Sun, SL; Schaefer, DJ; Weiss, M; Noy, ML; Cutler, CI; Sherman, JH; McFarland, EW; Stucky, GD; Ford, PC (Elsevier BV, 2004-11-24)
We describe a novel, integrated multi-step process for the partial oxidation of alkanes to alcohols, ethers or olefins using O-2 as oxidant. The sequential transformations are (1) alkane bromination to alkyl bromide(s) and HBr, (2) reaction of this mixture with solid metal oxide (MO) to neutralize the HBr and to generate oxygenated products or olefins plus solid metal bromide, and (3) oxidation of the spent solid with 02 to regenerate the metal oxide and Br-2 for reuse.
New, highly stable electrochromic polymers from 3,4-ethylenedioxythiophene-bis-substituted quinoxalines toward green polymeric materials
Durmus, Asuman; Günbaş, Emrullah Görkem; Toppare, Levent Kamil (American Chemical Society (ACS), 2007-12-11)
Two new highly stable electrochromic polymers, poly(5,8-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-2,3-di(thiophen-2-yl)quinoxaline) (PDETQ) and poly (5,8-bis(2,3 -dihydrothieno[3,4-b][ 1,4]dioxin-5yl)quinoxaline) (PDEQ) were synthesized, and their potential use as neutral state green polymeric materials was investigated. Spectroelectrochemistry showed that both polymers reveal two distinct absorption bands as expected for this type of donor-acceptor polymer, at 410 and 660 nm for PDEQ and 405 and 780 nm...
Using spilled over hydrogen in NH3 synthesis over supported Ru catalysts
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The role of spilled over hydrogen in ammonia synthesis reaction was monitored over Ru/SiO2, Ru/SBA15 and Ru/CNF using an in-situ DRIFTS cell reactor. Strongly bound hydrogen trapped on the metal and spilled over hydrogen trapped on the support due to a diffusion barrier remained on the surface after the overnight purge followed by hydrogen exposure over a reduced catalyst. When N-2 flow was introduced at room temperature, IR characteristic signals of NH3 were observed, indicating the formation of ammonia fr...
Citation Formats
H. H. Kazan, E. Ozcan, B. ÇOŞUT, G. YENİLMEZ ÇİFTÇİ, and E. TANRIVERDİ EÇİK, “Novel BODIPY-subphthalocyanine dyads with reasonable photodynamic therapy behaviours,” NEW JOURNAL OF CHEMISTRY, pp. 13738–13744, 2020, Accessed: 00, 2020. [Online]. Available: