Serum adiponectin, leptin, resistin and RBP4 levels in obese and metabolic syndrome children with nonalcoholic fatty liver disease

Date

2013-10-01

Author

Boyraz, Mehmet
Cekmez, Ferhat
Karaoglu, Abdulbaki
CİNAZ, PEYAMİ
Durak, Mustafa
BİDECİ, AYSUN

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

159
views

0
downloads

Aim: To investigate the relationship of adiponectin, leptin, resistin and RBP4 levels in obese and metabolic syndrome children with nonalcoholic fatty liver disease (NAFLD). Patients & methods: Group I consisted of 63 obese children with liver steatosis, group II consisted of 12 obese children with elevated serum ALT activity from group I, and group III included 85 obese children without liver steatosis. Results: Leptin levels were higher in the NAFLD children than in the control group. Serum RBP4 levels in obese children with NAFLD were higher than those in obese children without NAFLD and controls. Adiponectin and resistin levels were negatively correlated and RBP4 levels positively correlated with ALT activity and ultrasonographic grading. Conclusion: These data suggest that adiponectin, resistin and RBP4 may have a role in the pathogenesis of NAFLD in obese children. Adiponectin, leptin, resistin and RBP4 may be suitable markers for predicting metabolic syndrome and NAFLD.

Subject Keywords

Clinical Biochemistry, Drug Discovery, Biochemistry, medical

URI

https://hdl.handle.net/11511/68346

Journal

BIOMARKERS IN MEDICINE

DOI

https://doi.org/10.2217/bmm.13.13

Collections

Graduate School of Natural and Applied Sciences, Article

Suggestions

OpenMETU
Core

Relationship of adipokines (adiponectin, resistin and RBP4) with metabolic syndrome components in pubertal obese children Boyraz, Mehmet; Cekmez, Ferhat; Karaoglu, Abdulbaki; CİNAZ, PEYAMİ; Durak, Mustafa; BİDECİ, AYSUN (Future Medicine Ltd, 2013-06-01) Aim: To investigate the relationship between serum adiponectin, resistin and RBP4 levels and the components of metabolic syndrome. Patients & methods: Serum adiponectin, resistin and RBP4 levels were detected and analyzed in 148 8-18-year-old Turkish obese pubertal children with/without metabolic syndrome. Results: Adiponectin and resistin concentrations were significantly inversely correlated with BMI standard deviation score, homeostatic model assessment insulin resistance, waist circumference, triglyceri...
Effects of benzene on liver, kidney and lung cyp1a, cyp2b4, cyp2e1 and cyp3a6 mrna, protein level, and drug metabolizing enzyme activities and toxicity in diabetic rabbits Arslan, Şevki; Arınç, Emel; Department of Biochemistry (2008) The effects of diabetes on cytochrome P450 dependent drug metabolizing enzymes have not to be clarified yet. The most widely used animals in these studies have been rats, and information regarding the effects of diabetes on cytochrome P450 dependent procarcinogen/carcinogen metabolism in rabbits is limited. In the present study, we investigated, for the first time, the influence of benzene on liver, kidney and lung microsomal cytochrome P450 dependent drug metabolizing enzyme activities, protein and mRNA le...
Human serum arylesterase and glutathione s-transferase activities in patients with ischemic stroke compared to healthy controls Türkanoğlu, Aysun; Adalı, Orhan; Department of Biochemistry (2007) Stroke is an important public health problem and the third leading cause of death after coronary heart diesase and all cancers in all over the world. Free radicals and oxidative stress play important role in the pathogenesis of several diseases including atherosclerosis, stroke, cancer, neurodegenerative diseases such as Alzheimer's dementia. The activity of paraoxonase (PON1) aganist phenylacetate is known as arylesterase (ARE). Paraoxonase is an esterase associated with high-density lipoprotein (HDL) and ...
The effects of selenium on stz-induced diabetic rat kidney plasma membrane Gurbanov, Rafig; Severcan, Feride; Department of Biochemistry (2010) The kidney is one of the most affected organs of body from diabetes. Diabetic kidney disease is a complication of diabetes seen in 30-40% of diabetic person. The aim of this work is to contribute the useful information in the therapy of diabetes. It is very important to know the role of antioxidants at the molecular level during diabetes. The protecting role of antioxidants against lipid peroxidation, the effect of cellular antioxidant enzyme systems, understanding the changes of membrane fluidity, lipid or...
The serum immunoglobulin G glycosylation signature of gastric cancer Ruhaak, L. Renee; Barkauskas, Donald A.; Torres, Javier; Cooke, Cara L.; Wu, Lauren D.; Stroble, Carol; Özcan Kabasakal, Süreyya; Williams, Cynthia C.; Camorlinga, Margarita; Rocke, David M.; Lebrilla, Carlito B.; Solnick, Jay V. (Elsevier BV, 2015-03-01) Biomarkers may facilitate detection of gastric cancer at an earlier stage and reduce mortality. Here we sought to determine if the glycosylation profile of serum immunoglobulin G (IgG) could distinguish patients with non-atrophic gastritis (NAG), duodenal ulcer (DU) and gastric cancer (GC). Serum IgG was released and analyzed using nano-LC–TOF mass spectrometry. Statistically significant false discovery rate (FDR)-adjusted p-values were observed for 18 glycans, eight that differed significantly between NAG ...

Citation Formats

M. Boyraz, F. Cekmez, A. Karaoglu, P. CİNAZ, M. Durak, and A. BİDECİ, “Serum adiponectin, leptin, resistin and RBP4 levels in obese and metabolic syndrome children with nonalcoholic fatty liver disease,” BIOMARKERS IN MEDICINE, pp. 737–745, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/68346.