DNA Walker-Regulated Cancer Cell Growth Inhibition

Date

2016-06-01

Author

Li, Feiran
Cha, Tae-Gon
Pan, Jing
Özçelikkale, Altuğ
Han, Bumsoo
Choi, Jong Hyun

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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We demonstrate a DNAzyme-based walker system as a controlled oligonucleotide drug AS1411 release platform for breast cancer treatment. In this system, AS1411 strands are released from fuel strands as a walker moves along its carbon nanotube track. The release rate and amount of anticancer oligonucleotides are controlled by the walker operation. With a walker system embedded within the collagen extracellular matrix, we show that this drug release system can be used for in situ cancer cell growth inhibition.

Subject Keywords

Organic Chemistry, Molecular Medicine, Biochemistry, Molecular Biology

URI

https://hdl.handle.net/11511/69453

Journal

CHEMBIOCHEM

DOI

https://doi.org/10.1002/cbic.201600052

Collections

Department of Mechanical Engineering, Article

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Citation Formats

F. Li, T.-G. Cha, J. Pan, A. Özçelikkale, B. Han, and J. H. Choi, “DNA Walker-Regulated Cancer Cell Growth Inhibition,” CHEMBIOCHEM, pp. 1138–1141, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/69453.