Magnesium Oxide Nanocomposites for Improving Orthopedic Tissue Regeneration

Hıckey, Danıel
Sun, Lınlın
Ercan, Batur
Webster, Thomas
Where ligaments meet bone, there exists a transitional region of heterogeneous tissue that is graded from hard, highly mineralized fibrocartilage at the bone interface to un-mineralized soft tissue at the ligament. This structure, called the enthesis, disperses stress concentrations that arise due to the vastly different mechanical properties of bone and ligaments. However, in the event that a ligament is injured and requires surgery, the tendon-to-bone insertion site (TBI) must be destroyed and is not easily restored due to avascularity in the region and because of slow and disorganized healing within heterogeneous tissues. It is believed that this loss of enthesis functionality following joint reconstructive surgery is a leading cause of high failure rates for such surgeries (5-25% failure rates for ACL surgery) [1]. Therefore, there is considerable interest in the development of a nanostructured biomaterial that is capable of regenerating the TBI. In this study, magnesium oxide (MgO) nanoparticles were used to mineralize poly(l-lactic acid) (PLLA) and tested for their ability to improve the attachment and growth of TBI-related orthopedic tissue. Magnesium is an essential mineral in bone which is thought to regulate the size and density of hydroxyapatite (HA) crystals, and further, Weng and Webster demonstrated that nano-rough MgO increased bone cell density three-fold compared to bulk MgO [2]. Presently, the ability of these materials to promote tissue growth at the TBI was characterized via cell adhesion and proliferation experiments with fibroblasts and osteoblasts. Materials were also tested for their mechanical properties, and further characterization was performed using SEM, TEM, XRD, FTIR, EDS, and contact angle tests.
Citation Formats
D. Hıckey, L. Sun, B. Ercan, and T. Webster, “Magnesium Oxide Nanocomposites for Improving Orthopedic Tissue Regeneration,” presented at the Society For Biomaterials 2014 Annual Meeting and Exposition, (16 - 19 Nisan 2014), Northeastern University, Boston, MA, USA, 2014, Accessed: 00, 2021. [Online]. Available: