Department of Chemistry

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Toppare, Levent Kamil (480)
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Tanyeli, Cihangir (148)

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Recent Submissions

Overcoming the Barriers of Brain Cancer Treatment: Targeted and Fully NIR Absorbing Photodynamic Therapy Agents with Extremely Low Molecular Weights and Controlled Lipophilicity
Günbaş, Emrullah Görkem(2025-10-31)
Photodynamic therapy for brain tumours ; Brain cancer has a dismal five-year survival rate due to the high percentage of inoperable tumours and the limited number of drugs that can pass through the blood–brain barrier. Th...
Assessment of thermal and solvent stable SPME fibers for metabolomics studies performed in living systems
Kahremanoğlu, Kübra; Jaroch, Karol; Szeliska, Paulina; Filipiak, Wojciech; Charemski, Bartłomiej; Żuchowska, Karolina; Çetin, Enes; Eroğlu, Ahmet E.; Bojko, Barbara; Boyacı, Ezel (2025-05-15)
Solid phase microextraction (SPME), as a sampling/sample preparation technique, offers unique solutions for the most challenging applications, including metabolomics studies of living systems. However, for global metabolom...
Synthesis, molecular modeling, DFT studies, and enantioseparation of tetrahydro-4H-chromene derivatives with calcium channel blocking activity
KOÇAK ASLAN, EBRU; Karagüzel, Ayşe; Lam, Kevin; Dengiz, Çağatay; Huang, Sun; Burk, Ryan Jacob; Salehi, Reza; Sajeevan J, Siddharth Jaya; Zamponi, Gerald W.; Wolber, Gerhard; Armstrong, Daniel W.; Gündüz, Miyase Gözde (2025-05-15)
Calcium channel blockers are considered effective therapeutics in cardiovascular and neurological disorders. Herein, we replaced the nitrogen atom of 1,4-dihydropyridines (DHPs), the most popular group of calcium channel b...
Eu3+ doped MB4O7 (M= Ca and Sr) nanoparticles for cancer treatment
Yıldırım, İpek; Çetin Altındal, Damla; Yılmaz, Ayşen (2025-03-01)
Design, strategies and recent advances in conjugated polymers for supercapacitors
Cevher, Duygu; Çırpan, Ali (2025-02-15)
The discovery of clean and renewable energy sources has necessitated the advancement of efficient energy storage technologies and devices to ensure sustainable economic development. Batteries and supercapacitors play signi...
Thermoluminescence characterization of CaB4O7:Al (CBT:Al)synthesized by solid-state method
İflazoğlu, Sera; Emir Kafadar, Vural; Yılmaz, Ayşen (2025-02-01)
Continuous and systematic research into calcium tetraborate (CTB) is essential due to its potential as a promising material for dosimetric applications. This study focuses on developing a novel phosphor by doping CTB with ...
Effect of EDOT contribution on the electrochromic and capacitive properties of edot-carbazole based electrochromic polymer: Electrochromic and supercapacitor device applications
Cansu Ergun, Emine Gul; Önal, Ahmet Muhtar (2025-01-10)
3,4-ethylenedioxythiophene (EDOT) based donor-acceptor-donor (DAD) type conjugated polymers generally have extraordinary electrochromic properties due to the excellent nature of the EDOT unit. This work investigates the el...
Design and synthesis of heterocycle-based push-pull NLOphores: A comprehensive study of their linear and non-linear optical properties
Karagöllü, Başak; Şengöz, Tolga Orçun; Kayaş, Hazal; Erden, Kübra; ŞAHİN, Ertan; Esentürk, Okan; Dengiz, Çağatay (2025-01-01)
Push-pull chromophores, with strong intramolecular charge transfer (ICT), exhibit high ground-state polarization, driving strong NLO responses. The donor and acceptor abilities of the groups in the investigated compounds i...
Enantioselective Addition of 1,3,5,7-Tetramethyl-BODIPYs to Isatins by Bifunctional Quinine-Based Squaramides
Dündar, Esra; Isik, Murat; Yıldırım, Erol; Tanyeli, Cihangir (2025-01-01)
This work describes the development of the first enantioselective addition reaction between 1,3,5,7-tetramethyl-BODIPYs and isatin derivatives. The reaction utilizes bifunctional quinine/squaramide organocatalysts and affo...
Facile synthesis of unknown 6,7-dihydrofuro[3,4-c]pyridines and 3,4-diaryloylpyridines from N-homopropargylic β-enaminones
Yılmaz, Elif Serel; Kaya, Kerem; Zora, Metin (2025-01-01)
In this paper, we have uncovered a new reaction of N-homopropargylic β-enaminones, i.e. N-(4-phenyl-3-butynyl)-β-enaminones. When subjected to a reaction with excess molecular iodine or N-iodosuccinimide in the presence of...
Synthesis and electropolymerization of a selenophene based chemiluminescent monomer and its use in blood detection
Balci, Burcu; Çakal, Deniz; Cihaner, Atilla (2025-01-01)
A new selenophene based trimeric chemiluminescent compound, namely 5,7-di(selenophen-2-yl)-2,3-dihydrothieno[3,4-d]pyridazine-1,4-dione (S2T-Lum), was synthesized in two steps via electron donor-acceptor-donor approach. It...
Synergistic hybrid nanostructures for Ultra-Sensitive photoelectrochemical detection of hepatocellular carcinoma ctDNA
Okan, Meltem; Çağlayan Arslan, Zeynep; Aydın, Firdevs; Asil Alptekin, Demet; Külah, Haluk (2025-01-01)
In recent years, the integration of quantum dots (QDs) and upconverting nanoparticles (UCNPs) has emerged as a promising strategy in biomedical research, leveraging QDs’ efficient down-conversion and UCNPs’ remarkable up-c...
Carbamate-Functionalized NLOphores via a Formal [2+2] Cycloaddition-Retroelectrocyclization Strategy
Savaş, İpek; Çelik, Mehmet Efe; Barsella, Alberto; Dengiz, Çağatay (2025-01-01)
This study introduces a new donor group capable of activating click-type [2+2] cycloaddition-retroelectrocyclizations, generally known for their limited scope. Target chromophores were synthesized using isocyanate-free ure...
Novel Enyne-Modified 1,4-Thiazepines as Epidermal Growth Factor Receptor Inhibitors: Anticancer and Computational Studies
Atmaca, Harika; Pulat, Cisil Camli; Ilhan, Suleyman; Yılmaz, Elif Serel; Zora, Metin (2024-12-26)
1,4-Thiazepines (TZEPs) featuring enyne modifications represent promising candidates in cancer therapy. We synthesized novel TZEP derivatives and assessed their cytotoxicity, apoptosis induction, EGFR inhibition, and molec...
Application of Redox-Responsive Cysteine-Based Organogels as a Drug Delivery System for Doxorubicin
Zare, Diba; Yilmaz, Gamze; Özçubukçu, Salih (2024-12-25)
Cysteine derivatives having disulfide bonds in their side chains can be used as redox-responsive organogelators. The disulfide bond can be cleaved in the presence of certain reducing agents like thiol derivatives such as g...
Synthesis and thermoluminescence characterization of either Cu- or Ag-doped lithium triborate
İflazoğlu, Sera; Sevastidis, I.; Konstantinidis, P.G.; Yılmaz, Ayşen; Kitis, G.; Polymeris, G.S. (2024-12-01)
Lithium Triborate (LiB3O5 or LTB), is characterized by chemical stability and good mechanical properties, and it has an effective atomic number (Zeff = 7.39) close to that of the human tissue (Zeff = 7.42), making it a pot...
Unveiling the potential of direct synthesized PbS CQD ink based solar cells through numerical simulation
Uzun, Batuhan; Asil Alptekin, Demet (2024-12-01)
Studies on lead sulfide-PbS quantum dot-QD based solar cells have gained considerable attention in recent years. A direct synthesis-DS method has emerged that makes it possible to obtain PbS ink in a single step by elimina...
Electrosprayed MnFe2O4/PVDF membrane integrated microfluidic chip for amoxicillin removal with real-time monitoring of pH and dissolved oxygen
DABAGH, SHADAB; Javanifar, Roshan; KAYA, MEHMET DEMİR; EBRAHIMI, ALIAKBAR; GÜVEN, SİNAN; KAYA, BURAK MALİK; Esentürk, Okan; AŞKIN, AYŞEGÜL; DOĞAN GÜZEL, FATMA; UYSAL, ONUR; Sarıboyacı, Ayla Eker; Ghorbanpoor, Hamed; Avci, Huseyin (2024-12-01)
The increasing contamination of water with antibiotics presents significant environmental and health hazards, leading to a rise in antibiotic-resistant microorganisms. This work focused on the removal of one common pharmac...
Design and performance of sulfur and selenium-substituted triarylboron D3-A TADF emitters for OLED applications
Karakurt, Oğuzhan; Demirgezer, Elif Fatma; Daştemir, Murat; Cakmaktepe, Semih Can; Miranda-Salinas, Hector; Aksoy, Erkan; Danos, Andrew; Monkman, Andrew; Yıldırım, Erol; Çırpan, Ali (2024-11-01)
This study presents the design, synthesis, and comprehensive theoretical and photophysical analysis of two new D3-A type thermally activated delayed fluorescence (TADF) emitters for organic light-emitting diode (OLED) appl...
Development of Functional Cellulose Microspheres With Affinity Towards Bacterial Cells and Liposomes Containing Negatively Charged Phospholipids
Türkyılmaz, Serhan; Yılmaz, Ozan; Şahin, Fulya; Akbulut, Doğan; Demirel, Kaan (2024-09-18)
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