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Recent Submissions

Overcoming the Barriers of Brain Cancer Treatment: Targeted and Fully NIR Absorbing Photodynamic Therapy Agents with Extremely Low Molecular Weights and Controlled Lipophilicity Günbaş, Emrullah Görkem(2025-10-31) Photodynamic therapy for brain tumours ; Brain cancer has a dismal five-year survival rate due to the high percentage of inoperable tumours and the limited number of drugs that can pass through the blood–brain barrier. Th...
Protocol for the upgraded high-throughput SPME system for biocompatible in vitro extraction from small volume for metabolomics and pharmaceutical assays Szeliska, Paulina; Jaroch, Karol; Charemski, Bartłomiej; Kahremanoğlu, Kübra; Çetin, Enes; Boyacı, Ezel; Bojko, Barbara (2025-06-01) This study presents an updated application of Solid Phase Microextraction (SPME) technology for high-throughput, time-course metabolomic analysis in in vitro cell culture models. SPME, a versatile and minimally invasive sa...
Assessment of thermal and solvent stable SPME fibers for metabolomics studies performed in living systems Kahremanoğlu, Kübra; Jaroch, Karol; Szeliska, Paulina; Filipiak, Wojciech; Charemski, Bartłomiej; Żuchowska, Karolina; Çetin, Enes; Eroğlu, Ahmet E.; Bojko, Barbara; Boyacı, Ezel (2025-05-15) Solid phase microextraction (SPME), as a sampling/sample preparation technique, offers unique solutions for the most challenging applications, including metabolomics studies of living systems. However, for global metabolom...
Synthesis, molecular modeling, DFT studies, and enantioseparation of tetrahydro-4H-chromene derivatives with calcium channel blocking activity KOÇAK ASLAN, EBRU; Karagüzel, Ayşe; Lam, Kevin; Dengiz, Çağatay; Huang, Sun; Burk, Ryan Jacob; Salehi, Reza; Sajeevan J, Siddharth Jaya; Zamponi, Gerald W.; Wolber, Gerhard; Armstrong, Daniel W.; Gündüz, Miyase Gözde (2025-05-15) Calcium channel blockers are considered effective therapeutics in cardiovascular and neurological disorders. Herein, we replaced the nitrogen atom of 1,4-dihydropyridines (DHPs), the most popular group of calcium channel b...
Eu3+ doped MB4O7 (M= Ca and Sr) nanoparticles for cancer treatment Yıldırım, İpek; Çetin Altındal, Damla; Yılmaz, Ayşen (2025-03-01)
Design, strategies and recent advances in conjugated polymers for supercapacitors Cevher, Duygu; Çırpan, Ali (2025-02-15) The discovery of clean and renewable energy sources has necessitated the advancement of efficient energy storage technologies and devices to ensure sustainable economic development. Batteries and supercapacitors play signi...
Thermoluminescence characterization of CaB4O7:Al (CBT:Al)synthesized by solid-state method İflazoğlu, Sera; Emir Kafadar, Vural; Yılmaz, Ayşen (2025-02-01) Continuous and systematic research into calcium tetraborate (CTB) is essential due to its potential as a promising material for dosimetric applications. This study focuses on developing a novel phosphor by doping CTB with ...
Effect of EDOT contribution on the electrochromic and capacitive properties of edot-carbazole based electrochromic polymer: Electrochromic and supercapacitor device applications Cansu Ergun, Emine Gul; Önal, Ahmet Muhtar (2025-01-10) 3,4-ethylenedioxythiophene (EDOT) based donor-acceptor-donor (DAD) type conjugated polymers generally have extraordinary electrochromic properties due to the excellent nature of the EDOT unit. This work investigates the el...
Design and synthesis of heterocycle-based push-pull NLOphores: A comprehensive study of their linear and non-linear optical properties Karagöllü, Başak; Şengöz, Tolga Orçun; Kayaş, Hazal; Erden, Kübra; ŞAHİN, Ertan; Esentürk, Okan; Dengiz, Çağatay (2025-01-01) Push-pull chromophores, with strong intramolecular charge transfer (ICT), exhibit high ground-state polarization, driving strong NLO responses. The donor and acceptor abilities of the groups in the investigated compounds i...
Facile synthesis of unknown 6,7-dihydrofuro[3,4-c]pyridines and 3,4-diaryloylpyridines from N-homopropargylic β-enaminones Yılmaz, Elif Serel; Kaya, Kerem; Zora, Metin (2025-01-01) In this paper, we have uncovered a new reaction of N-homopropargylic β-enaminones, i.e. N-(4-phenyl-3-butynyl)-β-enaminones. When subjected to a reaction with excess molecular iodine or N-iodosuccinimide in the presence of...
Synthesis and electropolymerization of a selenophene based chemiluminescent monomer and its use in blood detection Balci, Burcu; Çakal, Deniz; Cihaner, Atilla (2025-01-01) A new selenophene based trimeric chemiluminescent compound, namely 5,7-di(selenophen-2-yl)-2,3-dihydrothieno[3,4-d]pyridazine-1,4-dione (S2T-Lum), was synthesized in two steps via electron donor-acceptor-donor approach. It...
Computational Identification of Potential Organocatalysts (CIPOC) Reveals a 2-aminoDMAP/Urea Catalyst Superior to Its Thiourea Analogue Alsancak-Koca, Sezen; Çamlısoy, Yeşim; Bakırcı, İrem; Işık, Murat; Çelebi-Ölçüm, Nihan; Tanyeli, Cihangir (2025-01-01) Asymmetric organocatalysis by bifunctional acid- and base-type small organic molecules has emerged as a promising way to enhance stereoselective organic transformations since the beginning of this millennium. Takemoto’s te...
Synergistic hybrid nanostructures for Ultra-Sensitive photoelectrochemical detection of hepatocellular carcinoma ctDNA Okan, Meltem; Çağlayan Arslan, Zeynep; Aydın, Firdevs; Asil Alptekin, Demet; Külah, Haluk (2025-01-01) In recent years, the integration of quantum dots (QDs) and upconverting nanoparticles (UCNPs) has emerged as a promising strategy in biomedical research, leveraging QDs’ efficient down-conversion and UCNPs’ remarkable up-c...
Carbamate-Functionalized NLOphores via a Formal [2+2] Cycloaddition-Retroelectrocyclization Strategy Savaş, İpek; Çelik, Mehmet Efe; Barsella, Alberto; Dengiz, Çağatay (2025-01-01) This study introduces a new donor group capable of activating click-type [2+2] cycloaddition-retroelectrocyclizations, generally known for their limited scope. Target chromophores were synthesized using isocyanate-free ure...
Enantioselective Addition of 1,3,5,7-Tetramethyl-BODIPYs to Isatins by Bifunctional Quinine-Based Squaramides Dündar, Esra; Isik, Murat; Yıldırım, Erol; Tanyeli, Cihangir (2025-01-01) This work describes the development of the first enantioselective addition reaction between 1,3,5,7-tetramethyl-BODIPYs and isatin derivatives. The reaction utilizes bifunctional quinine/squaramide organocatalysts and affo...
Novel Enyne-Modified 1,4-Thiazepines as Epidermal Growth Factor Receptor Inhibitors: Anticancer and Computational Studies Atmaca, Harika; Pulat, Cisil Camli; Ilhan, Suleyman; Yılmaz, Elif Serel; Zora, Metin (2024-12-26) 1,4-Thiazepines (TZEPs) featuring enyne modifications represent promising candidates in cancer therapy. We synthesized novel TZEP derivatives and assessed their cytotoxicity, apoptosis induction, EGFR inhibition, and molec...
Application of Redox-Responsive Cysteine-Based Organogels as a Drug Delivery System for Doxorubicin Zare, Diba; Yilmaz, Gamze; Özçubukçu, Salih (2024-12-25) Cysteine derivatives having disulfide bonds in their side chains can be used as redox-responsive organogelators. The disulfide bond can be cleaved in the presence of certain reducing agents like thiol derivatives such as g...
Synthesis and thermoluminescence characterization of either Cu- or Ag-doped lithium triborate İflazoğlu, Sera; Sevastidis, I.; Konstantinidis, P.G.; Yılmaz, Ayşen; Kitis, G.; Polymeris, G.S. (2024-12-01) Lithium Triborate (LiB3O5 or LTB), is characterized by chemical stability and good mechanical properties, and it has an effective atomic number (Zeff = 7.39) close to that of the human tissue (Zeff = 7.42), making it a pot...
Unveiling the potential of direct synthesized PbS CQD ink based solar cells through numerical simulation Uzun, Batuhan; Asil Alptekin, Demet (2024-12-01) Studies on lead sulfide-PbS quantum dot-QD based solar cells have gained considerable attention in recent years. A direct synthesis-DS method has emerged that makes it possible to obtain PbS ink in a single step by elimina...
Electrosprayed MnFe2O4/PVDF membrane integrated microfluidic chip for amoxicillin removal with real-time monitoring of pH and dissolved oxygen DABAGH, SHADAB; Javanifar, Roshan; KAYA, MEHMET DEMİR; EBRAHIMI, ALIAKBAR; GÜVEN, SİNAN; KAYA, BURAK MALİK; Esentürk, Okan; AŞKIN, AYŞEGÜL; DOĞAN GÜZEL, FATMA; UYSAL, ONUR; Sarıboyacı, Ayla Eker; Ghorbanpoor, Hamed; Avci, Huseyin (2024-12-01) The increasing contamination of water with antibiotics presents significant environmental and health hazards, leading to a rise in antibiotic-resistant microorganisms. This work focused on the removal of one common pharmac...

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