Polymeric materials in wound healing

Ulubayram, K
Hasırcı, Nesrin
There is a high need for rapid healing in the treatment of severe burns, trauma, diabetic, decubitus ulcers and other conditions where a great damage of the tissue is exist. In those cases, wound should be covered with a dressing which replaces the functions of the natural skin by protecting the loss of body fluid and proteins, preventing bacterial invasion, improving and stimulating the healing process by providing a support for the proliferating cells


EGF containing gelatin-based wound dressings
Ulubayram, K; Cakar, AN; Korkusuz, P; Ertan, C; Hasırcı, Nesrin (2001-06-01)
In case of bulk loss of tissue or non-healing wounds such as burns, trauma, diabetic, decubitus and venous stasis ulcers, a proper wound dressing is needed to cover the wound area, protect the damaged tissue, and if possible to activate the cell proliferation and stimulate the healing process. In this study, synthesis of a novel polymeric bilayer wound dressing containing epidermal growth-factor (EGF)-loaded microspheres was aimed. For this purpose, a natural, nontoxic and biocompatible material, gelatin, w...
A bilayer scaffold prepared from collagen and carboxymethyl cellulose for skin tissue engineering applications
Bektas, Cemile Kilic; Kimiz, Ilgin; ŞENDEMİR, AYLİN; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2018-01-01)
Treatment of chronic skin wound such as diabetic ulcers, burns, pressure wounds are challenging problems in the medical area. The aim of this study was to design a bilayer skin equivalent mimicking the natural one to be used as a tissue engineered skin graft for use in the treatments of problematic wounds, and also as a model to be used in research related to skin, such as determination of the efficacy of transdermal bioactive agents on skin cells and treatment of acute skin damages that require immediate r...
Heparin/Chitosan/Alginate Complex Scaffolds as Wound Dressings: Characterization and Antibacterial Study Against Staphylococcus epidermidis
AKSOY, EDA AYŞE; Sezer, Umran Aydemir; Kara, Filiz; Hasırcı, Nesrin (2015-02-01)
Infected wounds are global healthcare problems since they can lead to dysfunctioning in organs and even result in death in severe cases. In this study, antibacterial wound dressings were prepared to prevent possible infection at the damaged host region. For this purpose, three natural polymers namely heparin, chitosan and alginate were used as anionic, cationic and sulfated polysaccharides, respectively, due to their versatile properties as being nontoxic, biocompatible, biodegradable and antibacterial. Hep...
Epidermal growth factor-containing wound closure enhances wound healing in non-diabetic and diabetic rats
Dogan, S.; DEMİRER, SEHER; Kepenekci, I.; Erkek, B.; Kızıltay, Aysel; Hasırcı, Nesrin; MÜFTÜOĞLU, SEVDA FATMA; Nazikoglu, A.; Renda, N.; Dincer, U. D.; ELHAN, ATİLLA HALİL; Kuterdem, E. (2009-04-01)
Background: This study was designed to elucidate the in vivo efficacy of epidermal growth factor (EGF) on wound healing in non diabetic and diabetic rats.
Xanthan-gelatin and xanthan-gelatin-keratin wound dressings for local delivery of Vitamin C
Demir, Gizem Cigdem; Erdemli, Özge; Keskin, Dilek; Tezcaner, Ayşen (2022-02-01)
Recently, functional dressings that can protect the wound area from dehydration and bacterial infection and support healing have gained importance in place of passive dressings. This study aimed to develop temporary and regenerative xanthan/gelatin (XGH) and keratin/xanthan/gelatin hydrogels (KXGHs) that have high absorption capacity and applicability as a wound dressing that can provide local delivery of Vitamin C (VC). Firstly, xanthan/gelatin hydrogels were produced by crosslinking with different glycero...
Citation Formats
K. Ulubayram and N. Hasırcı, “Polymeric materials in wound healing,” 1997, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/52881.