Activity-Based Photosensitizers with Optimized Triplet State Characteristics Toward Cancer Cell Selective and Image Guided Photodynamic Therapy

Kilic, Eda
Almammadov, Toghrul
Etienne, Thibaud
Marıon, Antoıne
Günbaş, Emrullah Görkem
Kolemen, Safacan
© 2022 The Authors. Published by American Chemical Society.Activity-based theranostic photosensitizers are highly attractive in photodynamic therapy as they offer enhanced therapeutic outcome on cancer cells with an imaging opportunity at the same time. However, photosensitizers (PS) cores that can be easily converted to activity-based photosensitizers (aPSs) are still quite limited in the literature. In this study, we modified the dicyanomethylene-4H-chromene (DCM) core with a heavy iodine atom to get two different PSs (DCMO-I, I-DCMO-Cl) that can be further converted to aPS after simple modifications. The effect of iodine positioning on singlet oxygen generation capacity was also evaluated through computational studies. DCMO-I showed better performance in solution experiments and further proved to be a promising phototheranostic scaffold via cell culture studies. Later, a cysteine (Cys) activatable PS based on the DCMO-I core (DCMO-I-Cys) was developed, which induced selective photocytotoxicity along with a fluorescence turn-on response in Cys rich cancer cells.
ACS Applied Bio Materials


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© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Meso-substituted borondipyrromethene (BODIPY)-porphyrin compounds that include free base porphyrin with two different numbers of BODIPY groups (BDP-TTP and 3BDP-TTP) were designed and synthesized to analyze intramolecular energy transfer mechanisms of meso-substituted BODIPY-porphyrin dyads and the effect of the different numbers of BODIPY groups connected to free-base porphyrin on the energy transfer mechanism. Absorption spectra of BODIPY-porphyrin ...
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© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.In the present paper, we studied linear and nonlinear optical properties of lead molybdate (PbMoO4) single crystals grown by Czochralski method. Raman measurement was performed in the range of 50–1000 cm−1 and 11 active vibration modes were defined in the spectrum. The nature of the observed modes was discussed in detail. Optical absorption of the material was investigated utilizing room temperatu...
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© 2021 by the authors. Licensee MDPI, Basel, Switzerland.(1) Background: Implantation of metal-based scaffolds is a common procedure for treating several diseases. However, the success of the long-term application is limited by an insufficient endothelialization of the material surface. Nanostructured modifications of metal scaffolds represent a promising approach to faster biomaterial osteointegration through increasing of endothelial commitment of the mesenchymal stem cells (MSC). (2) Methods: Three diffe...
Citation Formats
E. Kilic et al., “Activity-Based Photosensitizers with Optimized Triplet State Characteristics Toward Cancer Cell Selective and Image Guided Photodynamic Therapy,” ACS Applied Bio Materials, pp. 0–0, 2022, Accessed: 00, 2022. [Online]. Available: