Activity-Based Photosensitizers with Optimized Triplet State Characteristics Toward Cancer Cell Selective and Image Guided Photodynamic Therapy

Date

2022-01-01

Author

Kilic, Eda
ELMAZOĞLU, ZÜBEYİR
Almammadov, Toghrul
KEPİL, DİLAY
Etienne, Thibaud
Marıon, Antoıne
Günbaş, Emrullah Görkem
Kolemen, Safacan

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

168
views

0
downloads

© 2022 The Authors. Published by American Chemical Society.Activity-based theranostic photosensitizers are highly attractive in photodynamic therapy as they offer enhanced therapeutic outcome on cancer cells with an imaging opportunity at the same time. However, photosensitizers (PS) cores that can be easily converted to activity-based photosensitizers (aPSs) are still quite limited in the literature. In this study, we modified the dicyanomethylene-4H-chromene (DCM) core with a heavy iodine atom to get two different PSs (DCMO-I, I-DCMO-Cl) that can be further converted to aPS after simple modifications. The effect of iodine positioning on singlet oxygen generation capacity was also evaluated through computational studies. DCMO-I showed better performance in solution experiments and further proved to be a promising phototheranostic scaffold via cell culture studies. Later, a cysteine (Cys) activatable PS based on the DCMO-I core (DCMO-I-Cys) was developed, which induced selective photocytotoxicity along with a fluorescence turn-on response in Cys rich cancer cells.

Subject Keywords

activatable photosensitizer, cancer, cysteine, DCM, photodynamic therapy

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85130823860&origin=inward
https://hdl.handle.net/11511/98001

Journal

ACS Applied Bio Materials

DOI

https://doi.org/10.1021/acsabm.2c00202

Collections

Department of Chemistry, Article

Suggestions

OpenMETU
Core

Mobility and the Role of Pedestrian in the Making of Public Space: The Case Study of Mersin Belge, Züleyha Sara; Akkar Ercan, Zübeyde Müge (2022-01-01) © 2022 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0)Public spaces, being inevitable components of cities, are evolving spaces that transform, expand or shrink. Ideally, they should be publicly-owned and controlled, equally accessible to all, and function in the public interest. As the main actor of public spaces, this research aims to reveal the roles of pedestrians’ behaviour and mobility in making pu...
Techno-economic comparative analysis of renewable energy systems: Case study in Zimbabwe Al-Ghussain, Loiy; Samu, Remember; Taylan, Onur; Fahrioglu, Murat (2020-09-01) © 2020 by the authors. Licensee MDPI, Basel, Switzerland.Fluctuations in fossil fuel prices significantly affect the economies of countries, especially oil-importing countries, hence these countries are thoroughly investigating the increase in the utilization of renewable energy resources as it is abundant and locally available in all the countries despite challenges. Renewable energy systems (RES) such as solar and wind systems offer suitable alternatives for fossil fuels and could ensure the energy securi...
Ultrafast electron/energy transfer and intersystem crossing mechanisms in bodipy-porphyrin compounds Tutel, Yusuf; Küçüköz, Betül; Yildiz, Elif Akhuseyin; Karatay, Ahmet; Dumanoğulları, Fatih Mehmet; Yılmaz, Halil; Hayvali, Mustafa; Elmali, Ayhan (2021-02-01) © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Meso-substituted borondipyrromethene (BODIPY)-porphyrin compounds that include free base porphyrin with two different numbers of BODIPY groups (BDP-TTP and 3BDP-TTP) were designed and synthesized to analyze intramolecular energy transfer mechanisms of meso-substituted BODIPY-porphyrin dyads and the effect of the different numbers of BODIPY groups connected to free-base porphyrin on the energy transfer mechanism. Absorption spectra of BODIPY-porphyrin ...
Linear and nonlinear optical characteristics of PbMoO4 single crystal for optoelectronic applications Delice, S.; Isik, M.; Hasanlı, Nızamı (2022-10-01) © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.In the present paper, we studied linear and nonlinear optical properties of lead molybdate (PbMoO4) single crystals grown by Czochralski method. Raman measurement was performed in the range of 50–1000 cm−1 and 11 active vibration modes were defined in the spectrum. The nature of the observed modes was discussed in detail. Optical absorption of the material was investigated utilizing room temperatu...
Nanostructured modifications of titanium surfaces improve vascular regenerative properties of exosomes derived from mesenchymal stem cells: Preliminary in vitro results Gardin, Chiara; Ferroni, Letizia; Erdoğan, Yaşar Kemal; Zanotti, Federica; De Francesco, Francesco; Trentini, Martina; Brunello, Giulia; Ercan, Batur; Zavan, Barbara (2021-12-01) © 2021 by the authors. Licensee MDPI, Basel, Switzerland.(1) Background: Implantation of metal-based scaffolds is a common procedure for treating several diseases. However, the success of the long-term application is limited by an insufficient endothelialization of the material surface. Nanostructured modifications of metal scaffolds represent a promising approach to faster biomaterial osteointegration through increasing of endothelial commitment of the mesenchymal stem cells (MSC). (2) Methods: Three diffe...

Citation Formats

E. Kilic et al., “Activity-Based Photosensitizers with Optimized Triplet State Characteristics Toward Cancer Cell Selective and Image Guided Photodynamic Therapy,” ACS Applied Bio Materials, pp. 0–0, 2022, Accessed: 00, 2022. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85130823860&origin=inward.