Synthesis of New Flexible Coumarin Dimers for Sodium and Potassium Differentiation

Akdağ, Akın
Using fluorescence to detect biologically relevant metals has been studied extensively due to its rapid and low detection limit ability. Sodium and potassium differentiation is significant in diagnosis of many medical conditions. For this, we designed coumarin dimers as flexible fluorescent probes using ethylene glycol units for differentiation of sodium and potassium. To our best knowledge, use of these easy-to-synthesize coumarin dimers linked through ethylene glycol units are first in the literature. In fluorescence titration experiments, diethylene glycol linked coumarin-3-carboxylate dimer is responsive for sodium ions but not for potassium ions. The driving force for the complexation of metal cation and fluorescence probes is thought to be size-matching. To further explain the phenomenon, we synthesized coumarin dimer using 1,8- octanediol as the linker, and methyl ester of coumarin-3-carboxylic acid to investigate the effect of structural changes on the fluorescence intensity. These two compounds could not differentiate the sodium and potassium. Flexible coumarin dimers as fluorophores are shown to be useful for sensing sodium cation in the presence of potassium cation.


Potassium sensing by using a newly synthesized squaraine dye in sol-gel matrix
Ertekin, K; Yenigul, B; Akkaya, EU (Springer Science and Business Media LLC, 2002-06-01)
Squaraines are a group of fluorescent dyes and pigments derived from squaric acid and dialkylanilines well known in applications such as photoreceptors, organic solar cells, optical recording media, and non-linear optics. Their very promising spectral properties, long wavelength absorption and emission, and high absorptivity and quantum yields have not been exploited so far in relation to optical sensor design. They exhibit excellent solubility in sol-gel matrices, and the ligand is an integral part of the ...
Examination of the dielectrophoretic spectra of MCF7 breast cancer cells and leukocytes
Çağlayan, Zeynep; Demircan Yalçın, Yağmur; Külah, Haluk (Wiley, 2020-03-01)
The detection of circulating tumor cells (CTCs) in blood is crucial to assess metastatic progression and to guide therapy. Dielectrophoresis (DEP) is a powerful cell surface marker-free method that allows intrinsic dielectric properties of suspended cells to be exploited for CTC enrichment/isolation from blood. Design of a successful DEP-based CTC enrichment/isolation system requires that the DEP response of the targeted particles should accurately be known. This paper presents a DEP spectrum method to inve...
Resistance to anticancer drugs permanently alters electrophoretic mobility of cancer cell lines
Kazan, Hasan Hueseyin; Urfali-Mamatoglu, Cagri; Guenduez, Ufuk (Wiley, 2017-04-01)
Electrophoretic mobility is a physical phenomenon defining the mobility of charged particles in a solution under applied electric field. As charged biological systems, living cells including both prokaryotes and eukaryotes have been assessed in terms of electrophoretic mobility to decipher their electrochemical structure. Moreover, determination of electrophoretic mobility of living cancer cells have promoted the advance exploration of the nature of the cancer cells and separation of cancer cells from norma...
Synthesis of CuO nanostructures on zeolite-Y and investigation of their CO2 adsorption properties
Boruban, Cansu; Nalbant Esentürk, Emren (2017-10-01)
Copper(II) oxide (CuO) nanoparticles (NPs) in two different morphologies, spiky and spherical, were synthesized on zeolite-Y by a modified impregnation method, and their CO2 adsorbing capabilities were investigated under standard conditions (1 atm and 298 K). The properties and CO2 adsorption performances of the hybrid systems were characterized by transmission electron microscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, X-ray photoelectron spectroscopy, atomic absorption s...
YAZGAN, A; Özcengiz, Gülay; ALAEDDINOGLU, NG (Springer Science and Business Media LLC, 1993-08-01)
Through preliminary plate tests, Kluyveromyces marxianus was found to be much more resistant to toxic heavy metals compared to a CUP1R strain of Saccharomyces cerevisiae. Specific growth rate and maximum dry weights affected by increasing metal concentrations were determined to obtain precise patterns of resistance. Metal biosorption was also monitored during the course of growth in synthetic media containing respective metals at 0.5 mM final concentration. Although Zn- and Co-binding was negligible, as muc...
Citation Formats
D. TAN and A. Akdağ, “Synthesis of New Flexible Coumarin Dimers for Sodium and Potassium Differentiation,” JOURNAL OF FLUORESCENCE, pp. 27–34, 2020, Accessed: 00, 2020. [Online]. Available: